DDI Drug Name |
DDI Drug ID |
Severity |
Mechanism |
Comorbidity |
REF |
Ivosidenib |
DM8S6T7
|
Major |
Increased risk of prolong QT interval by the combination of Halothane and Ivosidenib. |
Acute myeloid leukaemia [2A60]
|
[15] |
Midostaurin |
DMI6E0R
|
Moderate |
Increased risk of prolong QT interval by the combination of Halothane and Midostaurin. |
Acute myeloid leukaemia [2A60]
|
[14] |
Idarubicin |
DMM0XGL
|
Moderate |
Increased risk of prolong QT interval by the combination of Halothane and Idarubicin. |
Acute myeloid leukaemia [2A60]
|
[14] |
Arn-509 |
DMT81LZ
|
Moderate |
Increased risk of prolong QT interval by the combination of Halothane and Arn-509. |
Acute myeloid leukaemia [2A60]
|
[16] |
Gilteritinib |
DMTI0ZO
|
Moderate |
Increased risk of prolong QT interval by the combination of Halothane and Gilteritinib. |
Acute myeloid leukaemia [2A60]
|
[17] |
Ivabradine |
DM0L594
|
Major |
Increased risk of ventricular arrhythmias by the combination of Halothane and Ivabradine. |
Angina pectoris [BA40]
|
[16] |
Bepridil |
DM0RKS4
|
Major |
Increased risk of prolong QT interval by the combination of Halothane and Bepridil. |
Angina pectoris [BA40]
|
[14] |
Dronedarone |
DMA8FS5
|
Major |
Increased risk of prolong QT interval by the combination of Halothane and Dronedarone. |
Angina pectoris [BA40]
|
[14] |
Bedaquiline |
DM3906J
|
Major |
Increased risk of prolong QT interval by the combination of Halothane and Bedaquiline. |
Antimicrobial drug resistance [MG50-MG52]
|
[18] |
Cilostazol |
DMZMSCT
|
Moderate |
Increased risk of prolong QT interval by the combination of Halothane and Cilostazol. |
Arterial occlusive disease [BD40]
|
[14] |
Posaconazole |
DMUL5EW
|
Moderate |
Increased risk of prolong QT interval by the combination of Halothane and Posaconazole. |
Aspergillosis [1F20]
|
[14] |
Levalbuterol |
DM5YBO1
|
Moderate |
Increased risk of prolong QT interval by the combination of Halothane and Levalbuterol. |
Asthma [CA23]
|
[19] |
Pirbuterol |
DMI5678
|
Moderate |
Increased risk of prolong QT interval by the combination of Halothane and Pirbuterol. |
Asthma [CA23]
|
[20] |
Lisdexamfetamine |
DM6W8V5
|
Moderate |
Increased risk of prolong QT interval by the combination of Halothane and Lisdexamfetamine. |
Attention deficit hyperactivity disorder [6A05]
|
[16] |
Ofloxacin |
DM0VQN3
|
Moderate |
Increased risk of prolong QT interval by the combination of Halothane and Ofloxacin. |
Bacterial infection [1A00-1C4Z]
|
[21] |
Clarithromycin |
DM4M1SG
|
Moderate |
Increased risk of prolong QT interval by the combination of Halothane and Clarithromycin. |
Bacterial infection [1A00-1C4Z]
|
[14] |
Sparfloxacin |
DMB4HCT
|
Major |
Increased risk of prolong QT interval by the combination of Halothane and Sparfloxacin. |
Bacterial infection [1A00-1C4Z]
|
[21] |
Retigabine |
DMGNYIH
|
Moderate |
Increased risk of prolong QT interval by the combination of Halothane and Retigabine. |
Behcet disease [4A62]
|
[14] |
Eribulin |
DM1DX4Q
|
Moderate |
Increased risk of prolong QT interval by the combination of Halothane and Eribulin. |
Breast cancer [2C60-2C6Y]
|
[14] |
Lapatinib |
DM3BH1Y
|
Moderate |
Increased risk of prolong QT interval by the combination of Halothane and Lapatinib. |
Breast cancer [2C60-2C6Y]
|
[14] |
Alpelisib |
DMEXMYK
|
Moderate |
Increased metabolism of Halothane caused by Alpelisib mediated induction of CYP450 enzyme. |
Breast cancer [2C60-2C6Y]
|
[16] |
Bosutinib |
DMTI8YE
|
Moderate |
Increased risk of prolong QT interval by the combination of Halothane and Bosutinib. |
Breast cancer [2C60-2C6Y]
|
[16] |
PF-04449913 |
DMSB068
|
Moderate |
Increased risk of prolong QT interval by the combination of Halothane and PF-04449913. |
Chronic myelomonocytic leukaemia [2A40]
|
[22] |
Olodaterol |
DM62B78
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Halothane and Olodaterol. |
Chronic obstructive pulmonary disease [CA22]
|
[20] |
Vilanterol |
DMF5EK1
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Halothane and Vilanterol. |
Chronic obstructive pulmonary disease [CA22]
|
[19] |
Indacaterol |
DMQJHR7
|
Moderate |
Increased risk of prolong QT interval by the combination of Halothane and Indacaterol. |
Chronic obstructive pulmonary disease [CA22]
|
[20] |
Arformoterol |
DMYM974
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Halothane and Arformoterol. |
Chronic obstructive pulmonary disease [CA22]
|
[20] |
Probucol |
DMVZQ2M
|
Moderate |
Increased risk of prolong QT interval by the combination of Halothane and Probucol. |
Coronary atherosclerosis [BA80]
|
[14] |
Pasireotide |
DMHM7JS
|
Major |
Increased risk of prolong QT interval by the combination of Halothane and Pasireotide. |
Cushing syndrome [5A70]
|
[14] |
Osilodrostat |
DMIJC9X
|
Moderate |
Increased risk of prolong QT interval by the combination of Halothane and Osilodrostat. |
Cushing syndrome [5A70]
|
[16] |
Ivacaftor |
DMZC1HS
|
Moderate |
Decreased metabolism of Halothane caused by Ivacaftor mediated inhibition of CYP450 enzyme. |
Cystic fibrosis [CA25]
|
[23] |
MK-8228 |
DMOB58Q
|
Moderate |
Decreased metabolism of Halothane caused by MK-8228 mediated inhibition of CYP450 enzyme. |
Cytomegaloviral disease [1D82]
|
[24] |
Escitalopram |
DMFK9HG
|
Major |
Increased risk of prolong QT interval by the combination of Halothane and Escitalopram. |
Depression [6A70-6A7Z]
|
[14] |
Clomipramine |
DMINRKW
|
Moderate |
Increased risk of prolong QT interval by the combination of Halothane and Clomipramine. |
Depression [6A70-6A7Z]
|
[14] |
Tetrabenazine |
DMYWQ0O
|
Moderate |
Increased risk of prolong QT interval by the combination of Halothane and Tetrabenazine. |
Dissociative neurological symptom disorder [6B60]
|
[14] |
Deutetrabenazine |
DMUPFLI
|
Moderate |
Increased risk of prolong QT interval by the combination of Halothane and Deutetrabenazine. |
Dystonic disorder [8A02]
|
[25] |
Ingrezza |
DMVPLNC
|
Moderate |
Additive CNS depression effects by the combination of Halothane and Ingrezza. |
Dystonic disorder [8A02]
|
[26] |
Cenobamate |
DM8KLU9
|
Moderate |
Increased metabolism of Halothane caused by Cenobamate mediated induction of CYP450 enzyme. |
Epilepsy/seizure [8A61-8A6Z]
|
[27] |
Rufinamide |
DMWE60C
|
Moderate |
Increased metabolism of Halothane caused by Rufinamide mediated induction of CYP450 enzyme. |
Epilepsy/seizure [8A61-8A6Z]
|
[16] |
Solifenacin |
DMG592Q
|
Moderate |
Increased risk of prolong QT interval by the combination of Halothane and Solifenacin. |
Functional bladder disorder [GC50]
|
[14] |
Sunitinib |
DMCBJSR
|
Moderate |
Increased risk of prolong QT interval by the combination of Halothane and Sunitinib. |
Gastrointestinal stromal tumour [2B5B]
|
[14] |
Rifapentine |
DMCHV4I
|
Moderate |
Increased metabolism of Halothane caused by Rifapentine mediated induction of CYP450 enzyme. |
HIV-infected patients with tuberculosis [1B10-1B14]
|
[28] |
Fostemsavir |
DM50ILT
|
Moderate |
Increased risk of prolong QT interval by the combination of Halothane and Fostemsavir. |
Human immunodeficiency virus disease [1C60-1C62]
|
[29] |
Saquinavir |
DMG814N
|
Major |
Increased risk of prolong QT interval by the combination of Halothane and Saquinavir. |
Human immunodeficiency virus disease [1C60-1C62]
|
[30] |
Etravirine |
DMGV8QU
|
Moderate |
Increased metabolism of Halothane caused by Etravirine mediated induction of CYP450 enzyme. |
Human immunodeficiency virus disease [1C60-1C62]
|
[31] |
Lopinavir |
DMITQS0
|
Moderate |
Increased risk of prolong QT interval by the combination of Halothane and Lopinavir. |
Human immunodeficiency virus disease [1C60-1C62]
|
[14] |
Rilpivirine |
DMJ0QOW
|
Moderate |
Increased risk of prolong QT interval by the combination of Halothane and Rilpivirine. |
Human immunodeficiency virus disease [1C60-1C62]
|
[14] |
Darunavir |
DMN3GCH
|
Moderate |
Decreased metabolism of Halothane caused by Darunavir mediated inhibition of CYP450 enzyme. |
Human immunodeficiency virus disease [1C60-1C62]
|
[32] |
Polyethylene glycol |
DM4I1JP
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Halothane and Polyethylene glycol. |
Irritable bowel syndrome [DD91]
|
[16] |
Crizotinib |
DM4F29C
|
Major |
Increased risk of prolong QT interval by the combination of Halothane and Crizotinib. |
Lung cancer [2C25]
|
[33] |
Brigatinib |
DM7W94S
|
Moderate |
Increased metabolism of Halothane caused by Brigatinib mediated induction of CYP450 enzyme. |
Lung cancer [2C25]
|
[34] |
Ceritinib |
DMB920Z
|
Major |
Increased risk of prolong QT interval by the combination of Halothane and Ceritinib. |
Lung cancer [2C25]
|
[14] |
PF-06463922 |
DMKM7EW
|
Moderate |
Increased metabolism of Halothane caused by PF-06463922 mediated induction of CYP450 enzyme. |
Lung cancer [2C25]
|
[35] |
Osimertinib |
DMRJLAT
|
Major |
Increased risk of prolong QT interval by the combination of Halothane and Osimertinib. |
Lung cancer [2C25]
|
[36] |
Selpercatinib |
DMZR15V
|
Major |
Increased risk of prolong QT interval by the combination of Halothane and Selpercatinib. |
Lung cancer [2C25]
|
[16] |
Lumefantrine |
DM29GAD
|
Major |
Increased risk of prolong QT interval by the combination of Halothane and Lumefantrine. |
Malaria [1F40-1F45]
|
[37] |
Halofantrine |
DMOMK1V
|
Major |
Increased risk of prolong QT interval by the combination of Halothane and Halofantrine. |
Malaria [1F40-1F45]
|
[38] |
Hydroxychloroquine |
DMSIVND
|
Major |
Increased risk of prolong QT interval by the combination of Halothane and Hydroxychloroquine. |
Malaria [1F40-1F45]
|
[39] |
Inotuzumab ozogamicin |
DMAC130
|
Moderate |
Increased risk of prolong QT interval by the combination of Halothane and Inotuzumab ozogamicin. |
Malignant haematopoietic neoplasm [2B33]
|
[16] |
Idelalisib |
DM602WT
|
Moderate |
Decreased metabolism of Halothane caused by Idelalisib mediated inhibition of CYP450 enzyme. |
Mature B-cell leukaemia [2A82]
|
[40] |
IPI-145 |
DMWA24P
|
Moderate |
Decreased metabolism of Halothane caused by IPI-145 mediated inhibition of CYP450 enzyme. |
Mature B-cell leukaemia [2A82]
|
[41] |
Arsenic trioxide |
DM61TA4
|
Major |
Increased risk of prolong QT interval by the combination of Halothane and Arsenic trioxide. |
Mature B-cell lymphoma [2A85]
|
[42] |
Vemurafenib |
DM62UG5
|
Major |
Increased risk of prolong QT interval by the combination of Halothane and Vemurafenib. |
Melanoma [2C30]
|
[14] |
LGX818 |
DMNQXV8
|
Moderate |
Increased risk of prolong QT interval by the combination of Halothane and LGX818. |
Melanoma [2C30]
|
[43] |
Dabrafenib |
DMX6OE3
|
Moderate |
Increased metabolism of Halothane caused by Dabrafenib mediated induction of CYP450 enzyme. |
Melanoma [2C30]
|
[16] |
Exjade |
DMHPRWG
|
Moderate |
Decreased metabolism of Halothane caused by Exjade mediated inhibition of CYP450 enzyme. |
Mineral absorption/transport disorder [5C64]
|
[44] |
Panobinostat |
DM58WKG
|
Major |
Increased risk of prolong QT interval by the combination of Halothane and Panobinostat. |
Multiple myeloma [2A83]
|
[45] |
Siponimod |
DM2R86O
|
Major |
Increased risk of ventricular arrhythmias by the combination of Halothane and Siponimod. |
Multiple sclerosis [8A40]
|
[37] |
Fingolimod |
DM5JVAN
|
Major |
Increased risk of ventricular arrhythmias by the combination of Halothane and Fingolimod. |
Multiple sclerosis [8A40]
|
[14] |
Ozanimod |
DMT6AM2
|
Major |
Increased risk of ventricular arrhythmias by the combination of Halothane and Ozanimod. |
Multiple sclerosis [8A40]
|
[46] |
Romidepsin |
DMT5GNL
|
Moderate |
Increased risk of prolong QT interval by the combination of Halothane and Romidepsin. |
Mycosis fungoides [2B01]
|
[14] |
Nilotinib |
DM7HXWT
|
Major |
Increased risk of prolong QT interval by the combination of Halothane and Nilotinib. |
Myeloproliferative neoplasm [2A20]
|
[14] |
Dasatinib |
DMJV2EK
|
Moderate |
Increased risk of prolong QT interval by the combination of Halothane and Dasatinib. |
Myeloproliferative neoplasm [2A20]
|
[47] |
Prasugrel |
DM7MT6E
|
Minor |
Decreased metabolism of Halothane caused by Prasugrel mediated inhibition of CYP450 enzyme. |
Myocardial infarction [BA41-BA43]
|
[16] |
Entrectinib |
DMMPTLH
|
Moderate |
Increased risk of prolong QT interval by the combination of Halothane and Entrectinib. |
Non-small cell lung cancer [2C25]
|
[37] |
Levomethadyl Acetate |
DM06HG5
|
Major |
Increased risk of prolong QT interval by the combination of Halothane and Levomethadyl Acetate. |
Opioid use disorder [6C43]
|
[16] |
Lofexidine |
DM1WXA6
|
Moderate |
Increased risk of prolong QT interval by the combination of Halothane and Lofexidine. |
Opioid use disorder [6C43]
|
[14] |
Olaparib |
DM8QB1D
|
Moderate |
Increased metabolism of Halothane caused by Olaparib mediated induction of CYP450 enzyme. |
Ovarian cancer [2C73]
|
[37] |
Rucaparib |
DM9PVX8
|
Moderate |
Increased risk of prolong QT interval by the combination of Halothane and Rucaparib. |
Ovarian cancer [2C73]
|
[14] |
Triclabendazole |
DMPWGBR
|
Moderate |
Increased risk of prolong QT interval by the combination of Halothane and Triclabendazole. |
Parasitic worm infestation [1F90]
|
[14] |
Pimavanserin |
DMR7IVC
|
Moderate |
Increased risk of prolong QT interval by the combination of Halothane and Pimavanserin. |
Parkinsonism [8A00]
|
[48] |
Macimorelin |
DMQYJIR
|
Major |
Increased risk of prolong QT interval by the combination of Halothane and Macimorelin. |
Pituitary gland disorder [5A60-5A61]
|
[49] |
Lefamulin |
DME6G97
|
Major |
Increased risk of prolong QT interval by the combination of Halothane and Lefamulin. |
Pneumonia [CA40]
|
[50] |
Lonafarnib |
DMGM2Z6
|
Moderate |
Decreased metabolism of Halothane caused by Lonafarnib mediated inhibition of CYP450 enzyme. |
Premature ageing appearance [LD2B]
|
[51] |
Degarelix |
DM3O8QY
|
Moderate |
Increased risk of prolong QT interval by the combination of Halothane and Degarelix. |
Prostate cancer [2C82]
|
[16] |
ABIRATERONE |
DM8V75C
|
Moderate |
Increased risk of prolong QT interval by the combination of Halothane and ABIRATERONE. |
Prostate cancer [2C82]
|
[16] |
Enzalutamide |
DMGL19D
|
Moderate |
Increased risk of prolong QT interval by the combination of Halothane and Enzalutamide. |
Prostate cancer [2C82]
|
[16] |
Relugolix |
DMK7IWL
|
Moderate |
Increased risk of prolong QT interval by the combination of Halothane and Relugolix. |
Prostate cancer [2C82]
|
[16] |
Temsirolimus |
DMS104F
|
Moderate |
Increased plasma concentrations of Halothane and Temsirolimus due to competitive inhibition of the same metabolic pathway. |
Renal cell carcinoma [2C90]
|
[52] |
Quetiapine |
DM1N62C
|
Moderate |
Increased risk of prolong QT interval by the combination of Halothane and Quetiapine. |
Schizophrenia [6A20]
|
[14] |
Aripiprazole |
DM3NUMH
|
Moderate |
Increased risk of prolong QT interval by the combination of Halothane and Aripiprazole. |
Schizophrenia [6A20]
|
[37] |
Iloperidone |
DM6AUFY
|
Major |
Increased risk of prolong QT interval by the combination of Halothane and Iloperidone. |
Schizophrenia [6A20]
|
[14] |
Paliperidone |
DM7NPJS
|
Moderate |
Increased risk of prolong QT interval by the combination of Halothane and Paliperidone. |
Schizophrenia [6A20]
|
[14] |
Amisulpride |
DMSJVAM
|
Major |
Increased risk of prolong QT interval by the combination of Halothane and Amisulpride. |
Schizophrenia [6A20]
|
[53] |
Asenapine |
DMSQZE2
|
Moderate |
Increased risk of prolong QT interval by the combination of Halothane and Asenapine. |
Schizophrenia [6A20]
|
[14] |
Telotristat ethyl |
DMDIYFZ
|
Moderate |
Increased metabolism of Halothane caused by Telotristat ethyl mediated induction of CYP450 enzyme. |
Small intestine developmental anomaly [DA90]
|
[16] |
Larotrectinib |
DM26CQR
|
Moderate |
Decreased metabolism of Halothane caused by Larotrectinib mediated inhibition of CYP450 enzyme. |
Solid tumour/cancer [2A00-2F9Z]
|
[37] |
Armodafinil |
DMGB035
|
Minor |
Increased metabolism of Halothane caused by Armodafinil mediated induction of CYP450 enzyme. |
Solid tumour/cancer [2A00-2F9Z]
|
[54] |
LEE011 |
DMMX75K
|
Major |
Increased risk of prolong QT interval by the combination of Halothane and LEE011. |
Solid tumour/cancer [2A00-2F9Z]
|
[14] |
Vandetanib |
DMRICNP
|
Major |
Increased risk of prolong QT interval by the combination of Halothane and Vandetanib. |
Solid tumour/cancer [2A00-2F9Z]
|
[14] |
Triptorelin |
DMTK4LS
|
Moderate |
Increased risk of prolong QT interval by the combination of Halothane and Triptorelin. |
Solid tumour/cancer [2A00-2F9Z]
|
[16] |
Pitolisant |
DM8RFNJ
|
Moderate |
Increased metabolism of Halothane caused by Pitolisant mediated induction of CYP450 enzyme. |
Somnolence [MG42]
|
[16] |
Telavancin |
DM58VQX
|
Moderate |
Increased risk of prolong QT interval by the combination of Halothane and Telavancin. |
Staphylococcal/streptococcal disease [1B5Y]
|
[14] |
Fostamatinib |
DM6AUHV
|
Moderate |
Decreased metabolism of Halothane caused by Fostamatinib mediated inhibition of CYP450 enzyme. |
Thrombocytopenia [3B64]
|
[55] |
Lenvatinib |
DMB1IU4
|
Moderate |
Increased risk of prolong QT interval by the combination of Halothane and Lenvatinib. |
Thyroid cancer [2D10]
|
[14] |
Cabozantinib |
DMIYDT4
|
Major |
Increased risk of prolong QT interval by the combination of Halothane and Cabozantinib. |
Thyroid cancer [2D10]
|
[16] |
Trimeprazine |
DMEMV9D
|
Moderate |
Increased risk of prolong QT interval by the combination of Halothane and Trimeprazine. |
Vasomotor/allergic rhinitis [CA08]
|
[56] |
Propafenone |
DMPIBJK
|
Moderate |
Increased risk of prolong QT interval by the combination of Halothane and Propafenone. |
Ventricular tachyarrhythmia [BC71]
|
[14] |
Flecainide |
DMSQDLE
|
Moderate |
Increased risk of prolong QT interval by the combination of Halothane and Flecainide. |
Ventricular tachyarrhythmia [BC71]
|
[14] |
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