General Information of Drug (ID: DM80OZ5)

Drug Name
Halothane
Synonyms
Alotano; Anestan; Bromchlortrifluoraethanum; Bromochlorotrifluoroethane; Chalothane; Fluktan; Fluorotane; Fluothane; Ftorotan; Ftuorotan; Halan; Halotan; Halotano; Halothan; Halothanum; Halsan; Narcotan; Narcotane; Narkotan; Phthorothanum; Rhodialothan; Alotano [DCIT]; Ftorotan [Russian]; CF3CHClBr; Freon 123B1; Fluothane (TN); Halotano [INN-Spanish]; Halothane [Anaesthetics, volatile]; Halothanum [INN-Latin]; Narcotann NE-spofa [Russian]; Narcotann ne-spofa; Halothane [INN:BAN:JAN]; Halothane (JP15/USP/INN); (+-)-2-Bromo-2-chloro-1,1,1-trifluoroethane; 1,1,1-Trifluoro-2-bromo-2-chloroethane; 1,1,1-Trifluoro-2-chloro-2-bromoethane; 1-Bromo-1-chloro-2,2,2-trifluoroethane; 2,2,2-Trifluoro-1-chloro-1-bromoethane; 2-BROMO-2-CHLORO-1,1,1-TRIFLUOROETHANE; 2-Brom-2-chlor-1,1,1-trifluorethan
Indication
Disease Entry ICD 11 Status REF
Anaesthesia 9A78.6 Approved [1]
Therapeutic Class
Anesthetics
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 197.38
Logarithm of the Partition Coefficient (xlogp) 2.3
Rotatable Bond Count (rotbonds) 0
Hydrogen Bond Donor Count (hbonddonor) 0
Hydrogen Bond Acceptor Count (hbondacc) 3
ADMET Property
Metabolism
The drug is metabolized via the liver []
Adverse Drug Reaction (ADR)
ADR Term Variation Related DOT DOT ID REF
Adverse drug reaction Not Available GPT OTOXOA0Q [2]
Hepatotoxicity Not Available SORD OTC44CR6 [2]
Chemical Identifiers
Formula
C2HBrClF3
IUPAC Name
2-bromo-2-chloro-1,1,1-trifluoroethane
Canonical SMILES
C(C(F)(F)F)(Cl)Br
InChI
InChI=1S/C2HBrClF3/c3-1(4)2(5,6)7/h1H
InChIKey
BCQZXOMGPXTTIC-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
3562
ChEBI ID
CHEBI:5615
CAS Number
151-67-7
DrugBank ID
DB01159
TTD ID
D0D8VE
INTEDE ID
DR0803

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Glutamate receptor AMPA (GRIA) TTAN6JD NOUNIPROTAC Antagonist [3]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [4]
Cytochrome P450 2E1 (CYP2E1)
Main DME
DEVDYN7 CP2E1_HUMAN Substrate [5]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Substrate [6]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Substrate [4]
Cytochrome P450 2A6 (CYP2A6) DEJVYAZ CP2A6_HUMAN Substrate [7]
Cytochrome P450 2B6 (CYP2B6) DEPKLMQ CP2B6_HUMAN Substrate [8]
Microsomal cytochrome MCB5 (CYB5A) DE9A2LB CYB5_HUMAN Substrate [9]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Alanine aminotransferase 1 (GPT) OTOXOA0Q ALAT1_HUMAN Drug Response [2]
Albumin (ALB) OTVMM513 ALBU_HUMAN Protein Interaction/Cellular Processes [10]
Focal adhesion kinase 1 (PTK2) OT3Q1JDY FAK1_HUMAN Post-Translational Modifications [11]
Protein S100-A8 (S100A8) OTVMOB3F S10A8_HUMAN Gene/Protein Processing [12]
Ryanodine receptor 1 (RYR1) OTWUB65S RYR1_HUMAN Gene/Protein Processing [13]
Sorbitol dehydrogenase (SORD) OTC44CR6 DHSO_HUMAN Drug Response [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Anaesthesia
ICD Disease Classification 9A78.6
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Glutamate receptor AMPA (GRIA) DTT NO-GeName 1.79E-04 -0.69 -0.58
Cytochrome P450 2E1 (CYP2E1) DME CYP2E1 1.87E-04 -1.20E-01 -3.22E-01
Cytochrome P450 2B6 (CYP2B6) DME CYP2B6 4.88E-01 -1.69E-05 -1.28E-04
Cytochrome P450 2A6 (CYP2A6) DME CYP2A6 2.02E-01 -2.49E-02 -1.81E-01
Cytochrome P450 2D6 (CYP2D6) DME CYP2D6 7.30E-01 -1.91E-02 -1.41E-01
Microsomal cytochrome MCB5 (CYB5A) DME CYB5A 8.92E-01 2.47E-02 8.27E-02
Cytochrome P450 2C9 (CYP2C9) DME CYP2C9 1.90E-01 -9.81E-03 -5.96E-02
Cytochrome P450 3A4 (CYP3A4) DME CYP3A4 1.04E-02 6.29E-02 3.54E-01
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Same Disease as Halothane
DDI Drug Name DDI Drug ID Severity Mechanism Disease REF
Sevoflurane DMC9O43 Moderate Increased risk of prolong QT interval by the combination of Halothane and Sevoflurane. Corneal disease [9A76-9A78] [14]
Coadministration of a Drug Treating the Disease Different from Halothane (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Ivosidenib DM8S6T7 Major Increased risk of prolong QT interval by the combination of Halothane and Ivosidenib. Acute myeloid leukaemia [2A60] [15]
Midostaurin DMI6E0R Moderate Increased risk of prolong QT interval by the combination of Halothane and Midostaurin. Acute myeloid leukaemia [2A60] [14]
Idarubicin DMM0XGL Moderate Increased risk of prolong QT interval by the combination of Halothane and Idarubicin. Acute myeloid leukaemia [2A60] [14]
Arn-509 DMT81LZ Moderate Increased risk of prolong QT interval by the combination of Halothane and Arn-509. Acute myeloid leukaemia [2A60] [16]
Gilteritinib DMTI0ZO Moderate Increased risk of prolong QT interval by the combination of Halothane and Gilteritinib. Acute myeloid leukaemia [2A60] [17]
Ivabradine DM0L594 Major Increased risk of ventricular arrhythmias by the combination of Halothane and Ivabradine. Angina pectoris [BA40] [16]
Bepridil DM0RKS4 Major Increased risk of prolong QT interval by the combination of Halothane and Bepridil. Angina pectoris [BA40] [14]
Dronedarone DMA8FS5 Major Increased risk of prolong QT interval by the combination of Halothane and Dronedarone. Angina pectoris [BA40] [14]
Bedaquiline DM3906J Major Increased risk of prolong QT interval by the combination of Halothane and Bedaquiline. Antimicrobial drug resistance [MG50-MG52] [18]
Cilostazol DMZMSCT Moderate Increased risk of prolong QT interval by the combination of Halothane and Cilostazol. Arterial occlusive disease [BD40] [14]
Posaconazole DMUL5EW Moderate Increased risk of prolong QT interval by the combination of Halothane and Posaconazole. Aspergillosis [1F20] [14]
Levalbuterol DM5YBO1 Moderate Increased risk of prolong QT interval by the combination of Halothane and Levalbuterol. Asthma [CA23] [19]
Pirbuterol DMI5678 Moderate Increased risk of prolong QT interval by the combination of Halothane and Pirbuterol. Asthma [CA23] [20]
Lisdexamfetamine DM6W8V5 Moderate Increased risk of prolong QT interval by the combination of Halothane and Lisdexamfetamine. Attention deficit hyperactivity disorder [6A05] [16]
Ofloxacin DM0VQN3 Moderate Increased risk of prolong QT interval by the combination of Halothane and Ofloxacin. Bacterial infection [1A00-1C4Z] [21]
Clarithromycin DM4M1SG Moderate Increased risk of prolong QT interval by the combination of Halothane and Clarithromycin. Bacterial infection [1A00-1C4Z] [14]
Sparfloxacin DMB4HCT Major Increased risk of prolong QT interval by the combination of Halothane and Sparfloxacin. Bacterial infection [1A00-1C4Z] [21]
Retigabine DMGNYIH Moderate Increased risk of prolong QT interval by the combination of Halothane and Retigabine. Behcet disease [4A62] [14]
Eribulin DM1DX4Q Moderate Increased risk of prolong QT interval by the combination of Halothane and Eribulin. Breast cancer [2C60-2C6Y] [14]
Lapatinib DM3BH1Y Moderate Increased risk of prolong QT interval by the combination of Halothane and Lapatinib. Breast cancer [2C60-2C6Y] [14]
Alpelisib DMEXMYK Moderate Increased metabolism of Halothane caused by Alpelisib mediated induction of CYP450 enzyme. Breast cancer [2C60-2C6Y] [16]
Bosutinib DMTI8YE Moderate Increased risk of prolong QT interval by the combination of Halothane and Bosutinib. Breast cancer [2C60-2C6Y] [16]
PF-04449913 DMSB068 Moderate Increased risk of prolong QT interval by the combination of Halothane and PF-04449913. Chronic myelomonocytic leukaemia [2A40] [22]
Olodaterol DM62B78 Moderate Increased risk of ventricular arrhythmias by the combination of Halothane and Olodaterol. Chronic obstructive pulmonary disease [CA22] [20]
Vilanterol DMF5EK1 Moderate Increased risk of ventricular arrhythmias by the combination of Halothane and Vilanterol. Chronic obstructive pulmonary disease [CA22] [19]
Indacaterol DMQJHR7 Moderate Increased risk of prolong QT interval by the combination of Halothane and Indacaterol. Chronic obstructive pulmonary disease [CA22] [20]
Arformoterol DMYM974 Moderate Increased risk of ventricular arrhythmias by the combination of Halothane and Arformoterol. Chronic obstructive pulmonary disease [CA22] [20]
Probucol DMVZQ2M Moderate Increased risk of prolong QT interval by the combination of Halothane and Probucol. Coronary atherosclerosis [BA80] [14]
Pasireotide DMHM7JS Major Increased risk of prolong QT interval by the combination of Halothane and Pasireotide. Cushing syndrome [5A70] [14]
Osilodrostat DMIJC9X Moderate Increased risk of prolong QT interval by the combination of Halothane and Osilodrostat. Cushing syndrome [5A70] [16]
Ivacaftor DMZC1HS Moderate Decreased metabolism of Halothane caused by Ivacaftor mediated inhibition of CYP450 enzyme. Cystic fibrosis [CA25] [23]
MK-8228 DMOB58Q Moderate Decreased metabolism of Halothane caused by MK-8228 mediated inhibition of CYP450 enzyme. Cytomegaloviral disease [1D82] [24]
Escitalopram DMFK9HG Major Increased risk of prolong QT interval by the combination of Halothane and Escitalopram. Depression [6A70-6A7Z] [14]
Clomipramine DMINRKW Moderate Increased risk of prolong QT interval by the combination of Halothane and Clomipramine. Depression [6A70-6A7Z] [14]
Tetrabenazine DMYWQ0O Moderate Increased risk of prolong QT interval by the combination of Halothane and Tetrabenazine. Dissociative neurological symptom disorder [6B60] [14]
Deutetrabenazine DMUPFLI Moderate Increased risk of prolong QT interval by the combination of Halothane and Deutetrabenazine. Dystonic disorder [8A02] [25]
Ingrezza DMVPLNC Moderate Additive CNS depression effects by the combination of Halothane and Ingrezza. Dystonic disorder [8A02] [26]
Cenobamate DM8KLU9 Moderate Increased metabolism of Halothane caused by Cenobamate mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [27]
Rufinamide DMWE60C Moderate Increased metabolism of Halothane caused by Rufinamide mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [16]
Solifenacin DMG592Q Moderate Increased risk of prolong QT interval by the combination of Halothane and Solifenacin. Functional bladder disorder [GC50] [14]
Sunitinib DMCBJSR Moderate Increased risk of prolong QT interval by the combination of Halothane and Sunitinib. Gastrointestinal stromal tumour [2B5B] [14]
Rifapentine DMCHV4I Moderate Increased metabolism of Halothane caused by Rifapentine mediated induction of CYP450 enzyme. HIV-infected patients with tuberculosis [1B10-1B14] [28]
Fostemsavir DM50ILT Moderate Increased risk of prolong QT interval by the combination of Halothane and Fostemsavir. Human immunodeficiency virus disease [1C60-1C62] [29]
Saquinavir DMG814N Major Increased risk of prolong QT interval by the combination of Halothane and Saquinavir. Human immunodeficiency virus disease [1C60-1C62] [30]
Etravirine DMGV8QU Moderate Increased metabolism of Halothane caused by Etravirine mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [31]
Lopinavir DMITQS0 Moderate Increased risk of prolong QT interval by the combination of Halothane and Lopinavir. Human immunodeficiency virus disease [1C60-1C62] [14]
Rilpivirine DMJ0QOW Moderate Increased risk of prolong QT interval by the combination of Halothane and Rilpivirine. Human immunodeficiency virus disease [1C60-1C62] [14]
Darunavir DMN3GCH Moderate Decreased metabolism of Halothane caused by Darunavir mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [32]
Polyethylene glycol DM4I1JP Moderate Increased risk of ventricular arrhythmias by the combination of Halothane and Polyethylene glycol. Irritable bowel syndrome [DD91] [16]
Crizotinib DM4F29C Major Increased risk of prolong QT interval by the combination of Halothane and Crizotinib. Lung cancer [2C25] [33]
Brigatinib DM7W94S Moderate Increased metabolism of Halothane caused by Brigatinib mediated induction of CYP450 enzyme. Lung cancer [2C25] [34]
Ceritinib DMB920Z Major Increased risk of prolong QT interval by the combination of Halothane and Ceritinib. Lung cancer [2C25] [14]
PF-06463922 DMKM7EW Moderate Increased metabolism of Halothane caused by PF-06463922 mediated induction of CYP450 enzyme. Lung cancer [2C25] [35]
Osimertinib DMRJLAT Major Increased risk of prolong QT interval by the combination of Halothane and Osimertinib. Lung cancer [2C25] [36]
Selpercatinib DMZR15V Major Increased risk of prolong QT interval by the combination of Halothane and Selpercatinib. Lung cancer [2C25] [16]
Lumefantrine DM29GAD Major Increased risk of prolong QT interval by the combination of Halothane and Lumefantrine. Malaria [1F40-1F45] [37]
Halofantrine DMOMK1V Major Increased risk of prolong QT interval by the combination of Halothane and Halofantrine. Malaria [1F40-1F45] [38]
Hydroxychloroquine DMSIVND Major Increased risk of prolong QT interval by the combination of Halothane and Hydroxychloroquine. Malaria [1F40-1F45] [39]
Inotuzumab ozogamicin DMAC130 Moderate Increased risk of prolong QT interval by the combination of Halothane and Inotuzumab ozogamicin. Malignant haematopoietic neoplasm [2B33] [16]
Idelalisib DM602WT Moderate Decreased metabolism of Halothane caused by Idelalisib mediated inhibition of CYP450 enzyme. Mature B-cell leukaemia [2A82] [40]
IPI-145 DMWA24P Moderate Decreased metabolism of Halothane caused by IPI-145 mediated inhibition of CYP450 enzyme. Mature B-cell leukaemia [2A82] [41]
Arsenic trioxide DM61TA4 Major Increased risk of prolong QT interval by the combination of Halothane and Arsenic trioxide. Mature B-cell lymphoma [2A85] [42]
Vemurafenib DM62UG5 Major Increased risk of prolong QT interval by the combination of Halothane and Vemurafenib. Melanoma [2C30] [14]
LGX818 DMNQXV8 Moderate Increased risk of prolong QT interval by the combination of Halothane and LGX818. Melanoma [2C30] [43]
Dabrafenib DMX6OE3 Moderate Increased metabolism of Halothane caused by Dabrafenib mediated induction of CYP450 enzyme. Melanoma [2C30] [16]
Exjade DMHPRWG Moderate Decreased metabolism of Halothane caused by Exjade mediated inhibition of CYP450 enzyme. Mineral absorption/transport disorder [5C64] [44]
Panobinostat DM58WKG Major Increased risk of prolong QT interval by the combination of Halothane and Panobinostat. Multiple myeloma [2A83] [45]
Siponimod DM2R86O Major Increased risk of ventricular arrhythmias by the combination of Halothane and Siponimod. Multiple sclerosis [8A40] [37]
Fingolimod DM5JVAN Major Increased risk of ventricular arrhythmias by the combination of Halothane and Fingolimod. Multiple sclerosis [8A40] [14]
Ozanimod DMT6AM2 Major Increased risk of ventricular arrhythmias by the combination of Halothane and Ozanimod. Multiple sclerosis [8A40] [46]
Romidepsin DMT5GNL Moderate Increased risk of prolong QT interval by the combination of Halothane and Romidepsin. Mycosis fungoides [2B01] [14]
Nilotinib DM7HXWT Major Increased risk of prolong QT interval by the combination of Halothane and Nilotinib. Myeloproliferative neoplasm [2A20] [14]
Dasatinib DMJV2EK Moderate Increased risk of prolong QT interval by the combination of Halothane and Dasatinib. Myeloproliferative neoplasm [2A20] [47]
Prasugrel DM7MT6E Minor Decreased metabolism of Halothane caused by Prasugrel mediated inhibition of CYP450 enzyme. Myocardial infarction [BA41-BA43] [16]
Entrectinib DMMPTLH Moderate Increased risk of prolong QT interval by the combination of Halothane and Entrectinib. Non-small cell lung cancer [2C25] [37]
Levomethadyl Acetate DM06HG5 Major Increased risk of prolong QT interval by the combination of Halothane and Levomethadyl Acetate. Opioid use disorder [6C43] [16]
Lofexidine DM1WXA6 Moderate Increased risk of prolong QT interval by the combination of Halothane and Lofexidine. Opioid use disorder [6C43] [14]
Olaparib DM8QB1D Moderate Increased metabolism of Halothane caused by Olaparib mediated induction of CYP450 enzyme. Ovarian cancer [2C73] [37]
Rucaparib DM9PVX8 Moderate Increased risk of prolong QT interval by the combination of Halothane and Rucaparib. Ovarian cancer [2C73] [14]
Triclabendazole DMPWGBR Moderate Increased risk of prolong QT interval by the combination of Halothane and Triclabendazole. Parasitic worm infestation [1F90] [14]
Pimavanserin DMR7IVC Moderate Increased risk of prolong QT interval by the combination of Halothane and Pimavanserin. Parkinsonism [8A00] [48]
Macimorelin DMQYJIR Major Increased risk of prolong QT interval by the combination of Halothane and Macimorelin. Pituitary gland disorder [5A60-5A61] [49]
Lefamulin DME6G97 Major Increased risk of prolong QT interval by the combination of Halothane and Lefamulin. Pneumonia [CA40] [50]
Lonafarnib DMGM2Z6 Moderate Decreased metabolism of Halothane caused by Lonafarnib mediated inhibition of CYP450 enzyme. Premature ageing appearance [LD2B] [51]
Degarelix DM3O8QY Moderate Increased risk of prolong QT interval by the combination of Halothane and Degarelix. Prostate cancer [2C82] [16]
ABIRATERONE DM8V75C Moderate Increased risk of prolong QT interval by the combination of Halothane and ABIRATERONE. Prostate cancer [2C82] [16]
Enzalutamide DMGL19D Moderate Increased risk of prolong QT interval by the combination of Halothane and Enzalutamide. Prostate cancer [2C82] [16]
Relugolix DMK7IWL Moderate Increased risk of prolong QT interval by the combination of Halothane and Relugolix. Prostate cancer [2C82] [16]
Temsirolimus DMS104F Moderate Increased plasma concentrations of Halothane and Temsirolimus due to competitive inhibition of the same metabolic pathway. Renal cell carcinoma [2C90] [52]
Quetiapine DM1N62C Moderate Increased risk of prolong QT interval by the combination of Halothane and Quetiapine. Schizophrenia [6A20] [14]
Aripiprazole DM3NUMH Moderate Increased risk of prolong QT interval by the combination of Halothane and Aripiprazole. Schizophrenia [6A20] [37]
Iloperidone DM6AUFY Major Increased risk of prolong QT interval by the combination of Halothane and Iloperidone. Schizophrenia [6A20] [14]
Paliperidone DM7NPJS Moderate Increased risk of prolong QT interval by the combination of Halothane and Paliperidone. Schizophrenia [6A20] [14]
Amisulpride DMSJVAM Major Increased risk of prolong QT interval by the combination of Halothane and Amisulpride. Schizophrenia [6A20] [53]
Asenapine DMSQZE2 Moderate Increased risk of prolong QT interval by the combination of Halothane and Asenapine. Schizophrenia [6A20] [14]
Telotristat ethyl DMDIYFZ Moderate Increased metabolism of Halothane caused by Telotristat ethyl mediated induction of CYP450 enzyme. Small intestine developmental anomaly [DA90] [16]
Larotrectinib DM26CQR Moderate Decreased metabolism of Halothane caused by Larotrectinib mediated inhibition of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [37]
Armodafinil DMGB035 Minor Increased metabolism of Halothane caused by Armodafinil mediated induction of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [54]
LEE011 DMMX75K Major Increased risk of prolong QT interval by the combination of Halothane and LEE011. Solid tumour/cancer [2A00-2F9Z] [14]
Vandetanib DMRICNP Major Increased risk of prolong QT interval by the combination of Halothane and Vandetanib. Solid tumour/cancer [2A00-2F9Z] [14]
Triptorelin DMTK4LS Moderate Increased risk of prolong QT interval by the combination of Halothane and Triptorelin. Solid tumour/cancer [2A00-2F9Z] [16]
Pitolisant DM8RFNJ Moderate Increased metabolism of Halothane caused by Pitolisant mediated induction of CYP450 enzyme. Somnolence [MG42] [16]
Telavancin DM58VQX Moderate Increased risk of prolong QT interval by the combination of Halothane and Telavancin. Staphylococcal/streptococcal disease [1B5Y] [14]
Fostamatinib DM6AUHV Moderate Decreased metabolism of Halothane caused by Fostamatinib mediated inhibition of CYP450 enzyme. Thrombocytopenia [3B64] [55]
Lenvatinib DMB1IU4 Moderate Increased risk of prolong QT interval by the combination of Halothane and Lenvatinib. Thyroid cancer [2D10] [14]
Cabozantinib DMIYDT4 Major Increased risk of prolong QT interval by the combination of Halothane and Cabozantinib. Thyroid cancer [2D10] [16]
Trimeprazine DMEMV9D Moderate Increased risk of prolong QT interval by the combination of Halothane and Trimeprazine. Vasomotor/allergic rhinitis [CA08] [56]
Propafenone DMPIBJK Moderate Increased risk of prolong QT interval by the combination of Halothane and Propafenone. Ventricular tachyarrhythmia [BC71] [14]
Flecainide DMSQDLE Moderate Increased risk of prolong QT interval by the combination of Halothane and Flecainide. Ventricular tachyarrhythmia [BC71] [14]
⏷ Show the Full List of 109 DDI Information of This Drug

References

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40 Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
41 Product Information. Copiktra (duvelisib). Verastem, Inc., Needham, MA.
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43 Product Information. Braftovi (encorafenib). Array BioPharma Inc., Boulder, CO.
44 Product Information. Exjade (deferasirox). Novartis Pharmaceuticals, East Hanover, NJ.
45 Product Information. Farydak (panobinostat). Novartis Pharmaceuticals, East Hanover, NJ.
46 Product Information. Zeposia (ozanimod). Celgene Corporation, Summit, NJ.
47 Product Information. Sprycel (dasatinib). Bristol-Myers Squibb, Princeton, NJ.
48 Product Information. Nuplazid (pimavanserin). Accelis Pharma, East Windsor, NJ.
49 Product Information. Macrilen (macimorelin). Aeterna Zentaris, Charleston, SC.
50 Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
51 Product Information. Zokinvy (lonafarnib). Eiger BioPharmaceuticals, Palo Alto, CA.
52 Product Information. Prograf (tacrolimus). Fujisawa, Deerfield, IL.
53 Product Information. Barhemsys (amisulpride). Acacia Pharma, Inc, Indianapolis, IN.
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