General Information of Drug (ID: DMMRY0Z)

Drug Name
NPS-2390 Drug Info
Synonyms
N-(Adamantan-1-yl)quinoxaline-2-carboxamide; NPS 2390; 226878-01-9; NPS2390; N-(1-adamantyl)quinoxaline-2-carboxamide; CHEMBL399160; N-(adamantan-1-yl)quinoxaline-2-carboxamide; quinoxaline-2-carboxylic acid adamantan-1-ylamide; N-tricyclo[33113,7]dec-1-yl-2-quinoxalinecarboxamide; AC1OF2ZL; SCHEMBL659603; GTPL1384; NPS-239; DTXSID10427729; MolPort-003-351-281; ZKFVOZCCAXQXBU-UHFFFAOYSA-N; ZINC3966256; PDSP2_001301; BDBM50231744; PDSP1_001317; AKOS001304198; NPS-2390 solution, 30 mM in DMSO; N-(1-Adamantyl)-2-quinoxalinecarboxamide; Quinoxaline-2-carboxylic acid adamantan-1-ylamide
Indication
Disease Entry ICD 11 Status REF
Cerebrovascular ischaemia 8B1Z Preclinical [1]
Cross-matching ID
PubChem CID
7067728
CAS Number
CAS 226878-01-9
TTD Drug ID
DMMRY0Z

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Discontinued Drug(s)
Preclinical Drug(s)
Investigative Drug(s)
Approved Drug(s)
Clinical Trial Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
PF-1913539 DMXEU14 Alzheimer disease 8A20 Discontinued in Phase 3 [4]
AZD8529 DMEQ2N1 Schizophrenia 6A20 Discontinued in Phase 2 [5]
AZD-9272 DMYSBN3 Neuropathic pain 8E43.0 Discontinued in Phase 1 [6]
A-841720 DMSO8IE Pain MG30-MG3Z Preclinical [7]
LY-367385 DM98POQ Neurological disorder 6B60 Terminated [8]
[3H]quisqualate DMDQBTX Discovery agent N.A. Investigative [9]
L-CCG-I DMPZ8XH Discovery agent N.A. Investigative [10]
(1S,3R)-ACPD DM5DOAF Discovery agent N.A. Investigative [10]
(+)-MCPG DMG5QJB Discovery agent N.A. Investigative [11]
PHCCC DMNJY79 Discovery agent N.A. Investigative [12]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cinacalcet DMCX0K3 Hyperparathyroidism 5A51 Approved [13]
Etelcalcetide DMHP9BL Secondary hyperparathyroidism 5A51.1 Approved [14]
Encaleret DMQSPFS Autosomal dominant hypocalcemia 5A50.0Y Phase 3 [15]
ASP7991 DM3TN1A Hyperparathyroidism 5A51 Phase 2 [16]
MK-5442 DMHTIGU Osteoporosis FB83.0 Phase 2 [17]
ATF-936 DMWGKHZ Osteoporosis FB83.0 Phase 1 [18]
AXT-914 DM7ZU3B Osteoporosis FB83.0 Phase 1 [19]
R-568 DM5NWPD N. A. N. A. Discontinued in Phase 2 [20]
Ronacaleret DM10ZJP Osteoporosis FB83.0 Discontinued in Phase 2 [21]
NPS-2143 DMQPXLF Osteoporosis FB83.0 Discontinued in Phase 2 [22]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Extracellular calcium-sensing receptor (CASR) TTBUYHA CASR_HUMAN Modulator [2]
Metabotropic glutamate receptor 1 (mGluR1) TTVBPDM GRM1_HUMAN Inhibitor [3]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1384).
2 The Extracellular Calcium-Sensing Receptor (CASR) Regulates Gonadotropins-Induced Meiotic Maturation of Porcine Oocytes.Biol Reprod.2015 Dec;93(6):131.
3 Positive and negative modulation of group I metabotropic glutamate receptors. J Med Chem. 2008 Feb 14;51(3):634-47.
4 Pfizer. Product Development Pipeline. March 31 2009.
5 Clinical pipeline report, company report or official report of AstraZeneca (2009).
6 Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26.
7 Comparison of the mGluR1 antagonist A-841720 in rat models of pain and cognition. Behav Pharmacol. 2007 Jul;18(4):273-81.
8 Anticonvulsant actions of LY 367385 ((+)-2-methyl-4-carboxyphenylglycine) and AIDA ((RS)-1-aminoindan-1,5-dicarboxylic acid). Eur J Pharmacol. 1999 Feb 26;368(1):17-24.
9 Mutational analysis and molecular modeling of the allosteric binding site of a novel, selective, noncompetitive antagonist of the metabotropic glut... J Biol Chem. 2003 Mar 7;278(10):8340-7.
10 Characterization of [(3)H]Quisqualate binding to recombinant rat metabotropic glutamate 1a and 5a receptors and to rat and human brain sections. J Neurochem. 2000 Dec;75(6):2590-601.
11 [3H]R214127: a novel high-affinity radioligand for the mGlu1 receptor reveals a common binding site shared by multiple allosteric antagonists. Mol Pharmacol. 2003 May;63(5):1082-93.
12 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 289).
13 Clinical pipeline report, company report or official report of Amgen (2009).
14 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
15 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2023. Adis Insight
16 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800035616)
17 Antagonist for calcium-sensing receptor. JTT-305/MK-5442. Clin Calcium. 2011 Jan;21(1):89-93.
18 ATF936, a novel oral calcilytic, increases bone mineral density in rats and transiently releases parathyroid hormone in humans. Bone. 2011 Aug;49(2):233-41.
19 AXT914 a novel, orally-active parathyroid hormone-releasing drug in two early studies of healthy volunteers and postmenopausal women. Bone. 2014 Jul;64:204-10.
20 Mixed-effects modeling of the pharmacodynamic response to the calcimimetic agent R-568. Clin Pharmacol Ther. 1999 Jan;65(1):40-9.
21 Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).
22 Calcium-sensing receptor antagonist (calcilytic) NPS 2143 specifically blocks the increased secretion of endogenous Abeta42 prompted by exogenous fibrillary or soluble Abeta25-35 in human cortical astrocytes and neurons-therapeutic relevance to Alzheimer's disease. Biochim Biophys Acta. 2013 Oct;1832(10):1634-52.