Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMNCU6H)

• Drug Name: Neamine Drug Info
• Synonyms: Neamine; Neomycin A; Negamicin; Nebramycin X; Dekamycin V; 3947-65-7; Neamin; UNII-5981U00LY0; C12H26N4O6; BRN 0026714; 4-O-(2,6-Diamino-2,6-dideoxy-alpha-D-glucopyranosyl)-2-deoxy-D-streptamine; 2-Desoxy-4-O-(2,6-diamino-2,6-didesoxy-alpha-D-glucopyranosyl)-D-streptamin; CHEBI:7489; 5981U00LY0; (1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside; D-Streptamine, 2-deoxy-4-O-(2,6-diamino-2,6-dideoxy-alpha-D-glucopyranosyl)-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 72392
  ChEBI ID: CHEBI:7489
  CAS Number: CAS 3947-65-7
  TTD Drug ID: DMNCU6H

Molecule-Related Drug Atlas

Drug(s) Targeting Bacterial 16S ribosomal RNA (Bact 16S rRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Framycetin	DMF8DNE	Acute liver failure	DB91	Approved	[2]
Oxazolidinones	DMBM47Z	Gram-positive bacterial infection	1B74-1G40	Phase 2	[3]
Apramycin	DMU8QD2	Gram-negative bacterial infection	1B74-1G40	Phase 1	[1]
G418	DMKTJBU	Discovery agent	N.A.	Investigative	[1]
Hygromycin B	DMEZ92A	Discovery agent	N.A.	Investigative	[1]
Ribostamycin	DMXWUHA	Discovery agent	N.A.	Investigative	[1]
Butirosin B	DMR6GJK	Discovery agent	N.A.	Investigative	[1]
Aminodeoxykanamycin	DM79E2K	Discovery agent	N.A.	Investigative	[1]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial 16S ribosomal RNA (Bact 16S rRNA)	TT38DW5	NOUNIPROTAC	Inhibitor	[1]

References

• [1] RNA as a target for small molecules. Curr Opin Chem Biol. 2000 Dec;4(6):678-86.
• [2] Antistaphylococcal activity of gentamicin. Minerva Med. 1975 Dec 8;66(84):4505-26.
• [3] Ribosomal RNA is the target for oxazolidinones, a novel class of translational inhibitors. RNA. 1999 Jul;5(7):939-46.