Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMNZAVE)

Drug Name

1h-Benoximidazole-2-Carboxylic Acid Drug Info

Synonyms

1H-Benzimidazole-2-carboxylic acid; 2849-93-6; 2-Benzimidazolecarboxylic acid; 1H-benzo[d]imidazole-2-carboxylic acid; Benzimidazole-2-carboxylic acid; 1H-Benzoimidazole-2-carboxylic acid; 1H-1,3-benzodiazole-2-carboxylic acid; Benzoimidazole-2-carboxylic acid; benzimidazole-2-yl-carboxylic acid; 1H-BENOXIMIDAZOLE-2-CARBOXYLIC ACID; 1h-1,3-benzimidazole-2-carboxylic acid; RHXSYTACTOMVLJ-UHFFFAOYSA-N; PubChem8062; AC1L5PLZ; benzimidazolecarboxylic acid; AC1Q1HJ4; benzimidazole carboxylic acid; 2-Carboxy-1H-benzimidazole

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 233240
ChEBI ID: CHEBI:46117
CAS Number: CAS 2849-93-6
TTD Drug ID: DMNZAVE

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Cathepsin D (CTSD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID10498202C1	DMXE0F2	Multiple sclerosis	8A40	Clinical trial	[2]
CI-992	DMBHYIJ	Hypertension	BA00-BA04	Terminated	[3]
Alpha-D-Mannose	DMF5DLW	Discovery agent	N.A.	Investigative	[1]
Grassystatin a	DM1PWX2	Discovery agent	N.A.	Investigative	[4]
PMID8410973C3	DM6J5KY	Discovery agent	N.A.	Investigative	[5]
KNI-10006	DMMISH6	Discovery agent	N.A.	Investigative	[6]
GRL-7234	DMR93MK	Discovery agent	N.A.	Investigative	[7]
S-Methylcysteine	DMAMRKS	Discovery agent	N.A.	Investigative	[1]
Carbocyclic Peptidomimetic	DM87SOX	Discovery agent	N.A.	Investigative	[8]
N-Aminoethylmorpholine	DMWXBYC	Discovery agent	N.A.	Investigative	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cathepsin D (CTSD)	TTPT2QI	CATD_HUMAN	Inhibitor	[1]

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References

1	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
2	Synthesis and structure activity relationships of novel small molecule cathepsin D inhibitors. Bioorg Med Chem Lett. 1999 Sep 6;9(17):2531-6.
3	Structure-activity relationships of a series of 2-amino-4-thiazole-containing renin inhibitors. J Med Chem. 1992 Jul 10;35(14):2562-72.
4	Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation. J Med Chem. 2009 Sep 24;52(18):5732-47.
5	Specificity in the binding of inhibitors to the active site of human/primate aspartic proteinases: analysis of P2-P1-P1'-P2' variation. J Med Chem. 1993 Sep 3;36(18):2614-20.
6	alpha-Substituted norstatines as the transition-state mimic in inhibitors of multiple digestive vacuole malaria aspartic proteases. Bioorg Med Chem. 2009 Aug 15;17(16):5933-49.
7	Design, synthesis, and X-ray structure of potent memapsin 2 (beta-secretase) inhibitors with isophthalamide derivatives as the P2-P3-ligands. J Med Chem. 2007 May 17;50(10):2399-407.
8	Structure-based design, synthesis, and memapsin 2 (BACE) inhibitory activity of carbocyclic and heterocyclic peptidomimetics. J Med Chem. 2005 Aug 11;48(16):5175-90.