General Information of Drug (ID: DMOLFAU)

Drug Name
Thiopilocarpine Drug Info
Synonyms ENS-163; SDZ ENA-163; SDZ-ENS-163
Indication
Disease Entry ICD 11 Status REF
Cognitive impairment 6D71 Phase 1 [1]
Cross-matching ID
PubChem CID
189508
CAS Number
CAS 117707-51-4
TTD Drug ID
DMOLFAU

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
ACECLIDINE DMOLNCZ Glaucoma/ocular hypertension 9C61 Approved [2]
Fesoterodine fumarate DM13495 Overactive bladder GC50.0 Approved [3]
SMT-D002 DM1I93C Seborrhea ED91.2 Approved [4]
Clidinium DMUMQZ0 Abdominal stomach pain DD91.4 Approved [5]
Trihexyphenidyl DMB19L8 Dystonia 8A02 Approved [6]
Oxyphenonium DMMQHOZ Visceral spasms MD81.4 Approved [7]
Benztropine DMGZOVN Parkinson disease 8A00.0 Approved [8]
Glycopyrrolate DM2M3ZA Anaesthesia 9A78.6 Approved [9]
Pirenzepine DMP6M1N Peptic ulcer DA61 Approved [10]
Cycrimine DM8C43Q Parkinson disease 8A00.0 Approved [11]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Muscarinic acetylcholine receptor M1 (CHRM1) TTZ9SOR ACM1_HUMAN Agonist [1]

References

1 SDZ ENS 163, a selective muscarinic M1 receptor agonist, facilitates the induction of long-term potentiation in rat hippocampal slices. Eur J Pharmacol. 1992 Nov 3;222(1):21-5.
2 Design, synthesis, and neurochemical evaluation of 5-(3-alkyl-1,2,4- oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidines as M1 muscarinic receptor agonists. J Med Chem. 1993 Apr 2;36(7):842-7.
3 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
4 Demonstration of bladder selective muscarinic receptor binding by intravesical oxybutynin to treat overactive bladder. J Urol. 2004 Nov;172(5 Pt 1):2059-64.
5 Accidental acute clidinium toxicity. Emerg Med J. 2009 Jun;26(6):460.
6 The role of M1 muscarinic cholinergic receptors in the discriminative stimulus properties of N-desmethylclozapine and the atypical antipsychotic dr... Psychopharmacology (Berl). 2009 Apr;203(2):295-301.
7 Ultraviolet spectroscopic estimation of microenvironments and bitter tastes of oxyphenonium bromide in cyclodextrin solutions. J Pharm Sci. 1999 Aug;88(8):759-62.
8 Formulation and biopharmaceutical evaluation of transdermal patch containing benztropine. Int J Pharm. 2008 Jun 5;357(1-2):55-60.
9 Autonomic cardiovascular control during a novel pharmacologic alternative to ganglionic blockade. Clin Pharmacol Ther. 2008 May;83(5):692-701.
10 Negative crosstalk between M1 and M2 muscarinic autoreceptors involves endogenous adenosine activating A1 receptors at the rat motor endplate. Neurosci Lett. 2009 Aug 14;459(3):127-31.
11 Capillary gas chromatography of trihexyphenidyl, procyclidine and cycrimine in biological fluids. J Chromatogr. 1989 Sep 29;494:135-42.