Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMOXKIC)

Drug Name

MEDI3902 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Ventilator-associated pneumonia	PK81.0	Phase 2	[1]
Pseudomonas infection	1B92	Phase 1	[2]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting Pseudomonas PcrV protein type III (Pseudo pcrV)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
KB001A	DMTMCPZ	Cystic fibrosis	CA25	Phase 2	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Pseudomonas PcrV protein type III (Pseudo pcrV)	TTLK9NJ	O30527_PSEAI	Not Available	[3]
Pseudomonas Psl exopolysaccharide (Pseudo pslG)	TTTPDRC	Q9I1N2_PSEAE	Not Available	[3]

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References

1	ClinicalTrials.gov (NCT02696902) Effort to Prevent Nosocomial Pneumonia Caused by Pseudomonas Aeruginosa in Mechanically Ventilated Subjects
2	ClinicalTrials.gov (NCT02255760) Phase 1 Randomized Double-blind Placebo Controlled Study to Evaluate Safety and PK of MEDI3902 in Healthy Adults. U.S. National Institutes of Health.
3	A multifunctional bispecific antibody protects against Pseudomonas aeruginosa. Sci Transl Med. 2014 Nov 12;6(262):262ra155.
4	KB001-A, a novel anti-inflammatory, found to be safe and well-tolerated in cystic fibrosis patients infected with Pseudomonas aeruginosa. J Cyst Fibros. 2018 Jul;17(4):484-491.