Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMP5A4T)

Drug Name

Trilaciclib Drug Info

Synonyms

G1T28; 1374743-00-6; Trilaciclib [USAN]; G1T28(Trilaciclib); GTPL9626; CHEMBL3894860; SCHEMBL10082028; BDBM253928; US9464092, T; HY-101467; CS-0021431; 2'-((5-(4-methylpiperazin-1-yl)pyridin-2-yl)amino)-7',8'-dihydro-6'H-spiro(cyclohexane-1,9'-pyrazino(1',2':1,5)pyrrolo(2,3-d)pyrimidin)-6'-one; Spiro(cyclohexane-1,9'(6'H)-pyrazino(1',2':1,5)pyrrolo(2,3-d)pyrimidin)-6'-one, 7',8'-dihydro-2'-((5-(4-methyl-1-piperazinyl)-2-pyridinyl)amino)-; 2-[[5-(4-methylpiperazin-1-yl)pyridin-2-yl]amino]spiro[7,8-dihydropyra

Indication

Disease Entry	ICD 11	Status	REF
Small-cell lung cancer	2C25.Y	Approved	[1]
Triple negative breast cancer	2C60-2C65	Phase 2	[2]

Cross-matching ID

PubChem CID: 68029831
CAS Number: CAS 1374743-00-6
TTD Drug ID: DMP5A4T

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Cyclin-dependent kinase 4 (CDK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Apremilast	DMTWS9E	Psoriasis vulgaris	EA90	Approved	[3]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[4]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[5]
Ribociclib succinate	DM9CIUW	Breast cancer	2C60-2C65	Approved	[6]
LEE011	DMMX75K	Breast cancer	2C60-2C65	Phase 3	[7]
Ro 31-7453	DM83QCL	Solid tumour/cancer	2A00-2F9Z	Phase 2	[8]
P276-00	DM9DJL2	Mantle cell lymphoma	2A85.5	Phase 2	[9]
P-276	DMMJUHD	Breast cancer	2C60-2C65	Phase 2	[10]
G1T38	DMQO2IT	Breast cancer	2C60-2C65	Phase 2	[2]
GLR2007	DM7DWLY	Glioblastoma of brain	2A00.00	Phase 1/2	[11]
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Drug(s) Targeting Cyclin-dependent kinase 6 (CDK6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Apremilast	DMTWS9E	Psoriasis vulgaris	EA90	Approved	[3]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[4]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[5]
Ribociclib succinate	DM9CIUW	Breast cancer	2C60-2C65	Approved	[6]
LEE011	DMMX75K	Breast cancer	2C60-2C65	Phase 3	[7]
G1T38	DMQO2IT	Breast cancer	2C60-2C65	Phase 2	[2]
GLR2007	DM7DWLY	Glioblastoma of brain	2A00.00	Phase 1/2	[11]
FCN-437	DMQ8VUW	Breast cancer	2C60-2C65	Phase 1/2	[12]
FN-1501	DM7BMD6	Solid tumour/cancer	2A00-2F9Z	Phase 1	[13]
G1T28-1	DML028U	Solid tumour/cancer	2A00-2F9Z	Phase 1	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cyclin-dependent kinase 4 (CDK4)	TT0PG8F	CDK4_HUMAN	Inhibitor	[1]
Cyclin-dependent kinase 6 (CDK6)	TTO0FDJ	CDK6_HUMAN	Inhibitor	[1]

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References

1	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2021
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	Agreement signed with Prostagenics to develop prostate cancer treatment. Innovate Oncology, Inc. 2005.
4	Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
5	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2017
6	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
7	Dual CDK4/CDK6 inhibition induces cell-cycle arrest and senescence in neuroblastoma. Clin Cancer Res. 2013 Nov 15;19(22):6173-82.
8	A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22.
9	Cell cycle kinases as therapeutic targets for cancer. Nat Rev Drug Discov. 2009 Jul;8(7):547-66.
10	Liposarcoma: molecular genetics and therapeutics. Sarcoma. 2011;2011:483154.
11	Clinical pipeline report, company report or official report of Gan & Lee Pharmaceuticals.
12	Clinical pipeline report, company report or official report of Fochon Pharmaceuticals.
13	Discovery of 4-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrazole-3-carboxamide (FN-1501), an FLT3- and CDK-Kinase Inhibitor with Potentially High Efficiency against Acute Myelocytic Leukemia. J Med Chem. 2018 Feb 22;61(4):1499-1518.