Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMPH1RK)

Drug Name

Alferminogene tadenovec Drug Info

Synonyms

Generx (TN)

Indication

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Fibroblast growth factor-4 (FGF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[3]
Ad5FGF-4	DMVLWG7	Angina pectoris	BA40	Phase 3	[4]
Generx	DM1WMOK	Angina pectoris	BA40	Phase 3	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Fibroblast growth factor-4 (FGF4)	TTCEKVZ	FGF4_HUMAN	Modulator	[2]

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References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	Alferminogene tadenovec, an angiogenic FGF4 gene therapy for coronary artery disease. IDrugs. 2008 Apr;11(4):283-93.
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
4	Angiogenic gene therapy with adenovirus 5 fibroblast growth factor-4 (Ad5FGF-4): a new option for the treatment of coronary artery disease. Am J Cardiol. 2003 Nov 7;92(9B):24N-31N.
5	Effects of Ad5FGF-4 in patients with angina: an analysis of pooled data from the AGENT-3 and AGENT-4 trials. J Am Coll Cardiol. 2007 Sep 11;50(11):1038-46.