Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMPKO84)

Drug Name

PF-07220060 Drug Info

Indication

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Cyclin-dependent kinase 4 (CDK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Apremilast	DMTWS9E	Psoriasis vulgaris	EA90	Approved	[2]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[3]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[4]
Ribociclib Succinate	DM9CIUW	Breast cancer	2C60-2C65	Approved	[5]
Trilaciclib	DMP5A4T	Small-cell lung cancer	2C25.Y	Approved	[6]
LEE011	DMMX75K	Breast cancer	2C60-2C65	Phase 3	[7]
Ro 31-7453	DM83QCL	Solid tumour/cancer	2A00-2F9Z	Phase 2	[8]
P276-00	DM9DJL2	Mantle cell lymphoma	2A85.5	Phase 2	[9]
P-276	DMMJUHD	Breast cancer	2C60-2C65	Phase 2	[10]
G1T38	DMQO2IT	Breast cancer	2C60-2C65	Phase 2	[11]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	ClinicalTrials.gov (NCT04557449) Study to Test the Safety and Tolerability of PF-07220060 in Participants With Advance Solid Tumors (CDK4). U.S. National Institutes of Health.
2	Agreement signed with Prostagenics to develop prostate cancer treatment. Innovate Oncology, Inc. 2005.
3	Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
4	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2017
5	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
6	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2021
7	Dual CDK4/CDK6 inhibition induces cell-cycle arrest and senescence in neuroblastoma. Clin Cancer Res. 2013 Nov 15;19(22):6173-82.
8	A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22.
9	Cell cycle kinases as therapeutic targets for cancer. Nat Rev Drug Discov. 2009 Jul;8(7):547-66.
10	Liposarcoma: molecular genetics and therapeutics. Sarcoma. 2011;2011:483154.
11	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)