Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMQ0XYH)

Drug Name
Ethyl 1-[(1H-benzimidazol-5(6)-yl)sulfonyl]-1H-pyrrole-2-carboxylate Drug Info
Synonyms
ethyl 1-(3H-benzimidazol-5-ylsulfonyl)pyrrole-2-carboxylate; AC1LA3ZP; CTK6F6830; ZINC5884309; 1h-pyrrole-2-carboxylic acid,1-(1h-benzimidazol-6-ylsulfonyl)-,ethyl ester; 306964-90-9; KB-266409; ethyl 1-(1h-benzimidazol-6-ylsulfonyl)-1h-pyrrole-2-carboxylate; 1-(3H-Benzoimidazole-5-sulfonyl)-1H-pyrrole-2-carboxylic acid ethyl ester; 1-[(1H-Benzimidazole-5-yl)sulfonyl]1H-pyrrole-2-carboxylic acid ethyl ester
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
481117
TTD Drug ID
DMQ0XYH

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
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Drug(s) Targeting Human immunodeficiency virus Reverse transcriptase (HIV RT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [2]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [3]
Zalcitabine DMH7MUV Human immunodeficiency virus infection 1C62 Approved [4]
Tenofovir DM1IS6U Chronic hepatitis B virus infection Approved [2]
Lamivudine DMI347A Chronic HBV infection 1E51.0Z Approved [5]
Abacavir DMMN36E Human immunodeficiency virus infection 1C62 Approved [6]
Delavirdine DM3NF5G Human immunodeficiency virus infection 1C62 Approved [5]
Efavirenz DMC0GSJ Human immunodeficiency virus infection 1C62 Approved [5]
Rilpivirine DMJ0QOW Human immunodeficiency virus infection 1C62 Approved [7]
Etravirine DMGV8QU Human immunodeficiency virus-1 infection 1C62 Approved [8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
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Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Human immunodeficiency virus Reverse transcriptase (HIV RT) TT84ETX POL_HV1B1 Inhibitor [1]

References

1 Computer-assisted design, synthesis and biological evaluation of novel pyrrolyl heteroaryl sulfones targeted at HIV-1 reverse transcriptase as non-nucleoside inhibitors. Bioorg Med Chem. 2000 Sep;8(9):2305-9.
2 Antiviral drugs in current clinical use. J Clin Virol. 2004 Jun;30(2):115-33.
3 HIV-1 reverse transcriptase complex with DNA and nevirapine reveals non-nucleoside inhibition mechanism.Nat Struct Mol Biol.2012 Jan 22;19(2):253-9.
4 A peptide inhibitor of HIV-1 reverse transcriptase using alpha,beta-dehydro residues: a structure-based computer model. J Biomol Struct Dyn. 1998 Oct;16(2):347-54.
5 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
6 Quadruple nucleos(t)ide reverse transcriptase inhibitors-only regimen of tenofovir plus zidovudine/lamivudine/abacavir in heavily pre-treated HIV-1 infected patients: salvage therapy or backbone only Curr HIV Res. 2009 May;7(3):320-6.
7 Emerging antiviral drugs. Expert Opin Emerg Drugs. 2008 Sep;13(3):393-416.
8 2008 FDA drug approvals. Nat Rev Drug Discov. 2009 Feb;8(2):93-6.