General Information of Drug (ID: DMQ3O1U)

Drug Name
ABT-165 Drug Info
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 1 [1]
Cross-matching ID
TTD Drug ID
DMQ3O1U

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Approved Drug(s)
Drug(s) Targeting Delta-like protein 4 (DLL4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dilpacimab DMCATH2 Solid tumour/cancer 2A00-2F9Z Phase 2 [2]
Navicixizumab DMZ2G69 Colorectal cancer 2B91.Z Phase 1 [3]
NOV1501 DME2QUZ Solid tumour/cancer 2A00-2F9Z Phase 1 [4]
REGN-421 DMWJ0IH Solid tumour/cancer 2A00-2F9Z Phase 1 [5]
OMP-21M18 DMX1D0S Solid tumour/cancer 2A00-2F9Z Phase 1 [6]
Drug Name Drug ID Indication ICD 11 Highest Status REF
Brolucizumab DMW8QNG Wet age-related macular degeneration 9B78.3Z Approved [7]
Squalamine DM3PS2E Solid tumour/cancer 2A00-2F9Z Phase 3 [8]
PF-06439535 DMVHZDP Non-small-cell lung cancer 2C25.Y Phase 3 [9]
M710 DM1PRT6 Diabetic macular edema 9B71.02 Phase 3 [10]
FKB238 DM6R2XF Non-small-cell lung cancer 2C25.Y Phase 3 [11]
KSI-301 DMM2LTC Diabetic macular edema 9B71.02 Phase 3 [12]
TRS003 DMM1VOH Colorectal cancer 2B91.Z Phase 3 [13]
MYL-1402O DMXN2PP Non-small-cell lung cancer 2C25 Phase 3 [14]
SB15 DMTOS6C Neovascular age-related macular degeneration 9B78.3Z Phase 3 [15]
Dilpacimab DMCATH2 Solid tumour/cancer 2A00-2F9Z Phase 2 [2]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Delta-like protein 4 (DLL4) TTV23LH DLL4_HUMAN Inhibitor [1]
Vascular endothelial growth factor (VEGF) TT9HKJA VEGFA_HUMAN; VEGFB_HUMAN; VEGFC_HUMAN; VEGFD_HUMAN Inhibitor [1]

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 Apoptogenic activity of 2alpha,3alpha-dihydroxyurs-12-ene-28-oic acid from Prunella vulgaris var. lilacina is mediated via mitochondria-dependent activation of caspase cascade regulated by Bcl-2 in human acute leukemia Jurkat T cells. J Ethnopharmacol. 2011 Jun 1;135(3):626-35.
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4 Synergistic antitumor activity of a DLL4/VEGF bispecific therapeutic antibody in combination with irinotecan in gastric cancer. BMB Rep. 2020 Nov;53(10):533-538.
5 J Clin Oncol 31, 2013 (suppl; abstr 2502).
6 National Cancer Institute Drug Dictionary (drug id 614677).
7 Brolucizumab: First Approval. Drugs. 2019 Dec;79(18):1997-2000.
8 Clinical pipeline report, company report or official report of Ohr Pharmaceutical.
9 National Cancer Institute Drug Dictionary (drug id 43234).
10 ClinicalTrials.gov (NCT03610646) Comparative Study to Evaluate the Efficacy and Safety of MYL-1701P and Eylea in Subjects With Diabetic Macular Edema. U.S. National Institutes of Health.
11 Clinical pipeline report, company report or official report of Fujifilm.
12 Clinical pipeline report, company report or official report of Kodiak Sciences.
13 Prevalence of porcine cysticercosis in Vellore, South India. Trans R Soc Trop Med Hyg. 2013 Jan;107(1):62-4.
14 MYL-1402O: A Bevacizumab Biosimilar. Target Oncol. 2022 Jan;17(1):85-88.
15 Efficacy and Safety of the Aflibercept Biosimilar SB15 in Neovascular Age-Related Macular Degeneration: A Phase 3 Randomized Clinical Trial. JAMA Ophthalmol. 2023 Jul 1;141(7):668-676.