Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMQREP2)

• Drug Name: Tyr-D-Nle-Gly-D-Trp-NMeNle-Asp-Phe-NH2 Drug Info
• Synonyms: Tyr-D-Nle-Gly-D-Trp-NMeNle-Asp-Phe-NH2; CCK-Opioid Peptide, 12; CHEMBL408083; BDBM21142; (3S)-3-[(2S)-2-[(2R)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]hexanamido]acetamido}-3-(1H-indol-3-yl)-N-methylpropanamido]hexanamido]-3-{[(1S)-1-carbamoyl-2-phenylethyl]carbamoyl}propanoic acid

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 11614928
  TTD Drug ID: DMQREP2

Molecule-Related Drug Atlas

Drug(s) Targeting Gastrin/cholecystokinin type B receptor (CCKBR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pentagastrin	DMRCLZB	Diagnostic imaging	N.A.	Approved	[2]
Ceruletide	DM2WE5K	Caerulein stimulated gastric and pancreatic secretion	5A4Y	Approved	[3]
GASTRAZOLE	DMO3ITF	Duodenal ulcer	DA63	Phase 3	[4]
Dexloxiglumide	DM52HUD	Pancreatic malfunction	DC30-DC3Z	Phase 2	[5]
Spiroglumide	DM7NJWY	Stomach disease	DA43-DA4Y	Phase 2	[6]
TT-223	DMCDMFP	Type-1 diabetes	5A10	Phase 2	[7]
Z 360	DM2M80G	Discovery agent	N.A.	Phase 2	[8]
S-0509	DM4KWEF	Ulcerative colitis	DD71	Phase 2	[9]
YF-476	DM54MAJ	Stomach ulcer	DA60.Z	Phase 2	[10]
Itriglumide	DM5UFRO	Anxiety disorder	6B00-6B0Z	Phase 2	[11]

Drug(s) Targeting Cholecystokinin receptor type A (CCKAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexloxiglumide	DM52HUD	Pancreatic malfunction	DC30-DC3Z	Phase 2	[12]
proglumide	DM4MF9V	Influenza virus infection	1E30-1E32	Phase 2	[13]
Lintitript	DMS5X94	Obesity	5B81	Discontinued in Phase 2	[14]
Tarazepide	DMX6ZYE	Gastrointestinal disease	DE2Z	Discontinued in Phase 2	[15]
GI 181771	DMIUFS4	Obesity	5B81	Discontinued in Phase 2	[16]
Pranazepide	DMP43IR	Pancreatic malfunction	DC30-DC3Z	Discontinued in Phase 2	[17]
CE-326597	DMXO49B	Obesity	5B81	Discontinued in Phase 2	[18]
UCL-2000; butabindide	DML51D0	Obesity	5B81	Discontinued in Phase 1	[19]
SSR-125180	DMSOBW2	Obesity	5B81	Discontinued in Phase 1	[20]
T-0632	DML4M5K	Pancreatic malfunction	DC30-DC3Z	Discontinued in Phase 1	[21]

Drug(s) Targeting Opioid receptor mu (MOP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Buprenorphine	DMPRI8G	Opioid dependence	6C43.2Z	Approved	[22]
Morphine	DMRMS0L	Advanced cancer	2A00-2F9Z	Approved	[23]
Hydromorphone	DMHP21E	Back pain	ME84.Z	Approved	[24]
Tapentadol hydrochloride	DMXLSH3	Acute pain	MG31	Approved	[25]
Fentanyl	DM8WAHT	Analgesia	MB40.8	Approved	[26]
Alfentanil	DMVO0UB	Anaesthesia	9A78.6	Approved	[27]
Naloxegol	DML0B41	Opioid-induced constipation	DB32.1	Approved	[28]
Eluxadoline	DMYZ0P1	Diarrhea-predominant irritable bowel syndrome	DD91.01	Approved	[29]
Nalfurafine hcl	DMA9DHW	Uremic pruritus	EC90.10	Approved	[30]
Oxycodone	DMXLKHV	Osteoarthritis	FA00-FA05	Approved	[31]

Drug(s) Targeting Opioid receptor delta (OPRD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Codeine	DMJX6ZG	Allergic rhinitis	CA08.0	Approved	[32]
Hydromorphone	DMHP21E	Back pain	ME84.Z	Approved	[33]
Loperamide	DMOJZQ9	Diarrhea	ME05.1	Approved	[34]
Eluxadoline	DMYZ0P1	Diarrhea-predominant irritable bowel syndrome	DD91.01	Approved	[29]
Oxycodone	DMXLKHV	Osteoarthritis	FA00-FA05	Approved	[35]
Butorphanol	DM5KYPJ	Pain	MG30-MG3Z	Approved	[32]
Carfentanil	DM7ADGX	N. A.	N. A.	Phase 2	[36]
Met-enkephalin	DMSZFTP	Pain	MG30-MG3Z	Phase 2	[37]
AZD-2327	DM8FZOG	Anxiety disorder	6B00-6B0Z	Phase 2	[38]
ADL-5747	DMMUPTN	Pain	MG30-MG3Z	Phase 2	[39]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cholecystokinin receptor type A (CCKAR)	TTCG0AL	CCKAR_HUMAN	Inhibitor	[1]
Gastrin/cholecystokinin type B receptor (CCKBR)	TTVFO0U	GASR_HUMAN	Inhibitor	[1]
Opioid receptor delta (OPRD1)	TT27RFC	OPRD_HUMAN	Inhibitor	[1]
Opioid receptor mu (MOP)	TTKWM86	OPRM_HUMAN	Inhibitor	[1]

References

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