Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMR2MUG)

Drug Name

ACULEACIN A Drug Info

Synonyms

Aculeacin A; 58814-86-1; AC1Q6G0M; AC1L3U84; YKPHLXGEPNYRPY-UHFFFAOYSA-N; LS-14909; n-{23-[1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-2,11,12,15-tetrahydroxy-6,20-bis(1-hydroxyethyl)-16-methyl-5,8,14,19,22,25-hexaoxotetracosahydro-1h-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl}hexadecanamide; Echinocandin B, 1-((4R,5R)-4,5-dihydroxy-N(sup 2)-(1-oxohexadecyl)-L-ornithine)-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 14315169
TTD Drug ID: DMR2MUG

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Discontinued Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Fungal Papulacandin B resistance protein 1 (Fung FKS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cilofungin	DMBNWM1	Candidiasis	1F23	Terminated	[2]
L-692289	DMAB1RW	Discovery agent	N.A.	Investigative	[3]
Pyridobenzimidazole	DM3PAS4	Fungal infection	1F29-1F2F	Investigative	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Fungal Papulacandin B resistance protein 1 (Fung FKS1)	TTZMS1L	FKS1_YEAST	Inhibitor	[1]

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References

1	Synthesis, anti-fungal and 1,3--D-glucan synthase inhibitory activities of caffeic and quinic acid derivatives. Bioorg Med Chem. 2010 Oct 1;18(19):7009-14.
2	Cryptococcus neoformans resistance to echinocandins: (1,3)beta-glucan synthase activity is sensitive to echinocandins. Antimicrob Agents Chemother. 2005 Jul;49(7):2851-6.
3	Antifungal lipopeptides: Structure-activity relationships of 3-hydroxyglutamine-modified pneumocandin B0 derivatives, Bioorg. Med. Chem. Lett. 5(20):2357-2362 (1995).
4	Novel antifungal agents, targets or therapeutic strategies for the treatment of invasive fungal diseases: a review of the literature (2005-2009). Rev Iberoam Micol. 2009 Mar 31;26(1):15-22.