General Information of Drug (ID: DMR7TEQ)

Drug Name
[D-4Aph(CO-NH-OCH3)6]degarelix Drug Info
Synonyms CHEMBL435141; [D-4Aph(CO-NH-OCH3)6]degarelix
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
16155709
TTD Drug ID
DMR7TEQ

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gonadorelin DMAQ469 Amenorrhea GA20.0 Approved [2]
Relugolix DMK7IWL Prostate cancer 2C82.0 Approved [3]
Ganirelix DMGMB30 Ovulation dysfunction 5A80 Approved [4]
Abarelix DM5WFNP Prostate cancer 2C82.0 Approved [5]
Triptorelin DMTK4LS Infertility GB04 Approved [6]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [7]
Nafarelin DMAHEFY Endometriosis GA10 Approved [8]
Cetrorelix DMFD9Q6 Ovarian stimulation LB45.1 Approved [9]
Elagolix sodium DMRDUC0 Endometriosis GA10 Approved [10]
Degarelix DM3O8QY Prostate cancer 2C82.0 Approved [11]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Gonadotropin-releasing hormone receptor (GNRHR) TT8R70G GNRHR_HUMAN Inhibitor [1]

References

1 Novel analogues of degarelix incorporating hydroxy-, methoxy-, and pegylated-urea moieties at positions 3, 5, 6 and the N-terminus. Part III. J Med Chem. 2006 Jun 15;49(12):3536-43.
2 Use of cognitive behavior therapy for functional hypothalamic amenorrhea. Ann N Y Acad Sci. 2006 Dec;1092:114-29.
3 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020
4 Age attenuates testosterone secretion driven by amplitude-varying pulses of recombinant human luteinizing hormone during acute gonadotrope inhibiti... J Clin Endocrinol Metab. 2007 Sep;92(9):3626-32.
5 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
6 Regulation of GnRH I receptor gene expression by the GnRH agonist triptorelin, estradiol, and progesterone in the gonadotroph-derived cell line alphaT3-1. Endocrine. 2006 Aug;30(1):139-44.
7 Clinical pipeline report, company report or official report of Takeda (2009).
8 Reversible downregulation of endocrine and germinative testicular function (hormonal castration) in the dog with the GnRH-agonist azagly-nafarelin ... Theriogenology. 2009 Apr 15;71(7):1037-45.
9 Gonadotropin releasing hormone analogs induce apoptosis by extrinsic pathway involving p53 phosphorylation in primary cell cultures of human prostatic adenocarcinomas. Prostate. 2009 Jul 1;69(10):1025-33.
10 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
11 Iterative approach to the discovery of novel degarelix analogues: substitutions at positions 3, 7, and 8. Part II. J Med Chem. 2005 Jul 28;48(15):4851-60.