Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMRQZTS)

• Drug Name: diphenylboronic anhydride Drug Info
• Synonyms: diphenylborinic anhydride

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 596810
  CAS Number: CAS 4426-21-5
  TTD Drug ID: DMRQZTS

Molecule-Related Drug Atlas

Drug(s) Targeting Transient receptor potential cation channel V3 (TRPV3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SAR292833	DM63QY0	Pain	MG30-MG3Z	Phase 2	[5]
2-APB	DM9AKVR	Discovery agent	N.A.	Investigative	[6]
citral	DM53ZGY	Discovery agent	N.A.	Investigative	[7]
aspirin-triggered resolvin D1	DMOP941	Discovery agent	N.A.	Investigative	[8]
carvacrol	DMINM2D	Discovery agent	N.A.	Investigative	[9]
cinnamaldehyde	DMZDUXG	Discovery agent	N.A.	Investigative	[10]
diphenyltetrahydrofuran	DMK8T61	Discovery agent	N.A.	Investigative	[4]
carveol	DMGIZ5U	Discovery agent	N.A.	Investigative	[11]
dihydrocarveol	DMS4U68	Discovery agent	N.A.	Investigative	[11]
tetrahydrocannabivarin	DMDY1MZ	Discovery agent	N.A.	Investigative	[12]

Drug(s) Targeting Transient receptor potential cation channel V2 (TRPV2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
[14C]TEA	DM6SFYH	Discovery agent	N.A.	Investigative	[3]
2-APB	DM9AKVR	Discovery agent	N.A.	Investigative	[3]
lysophosphatidylcholine	DMOGFVH	Discovery agent	N.A.	Investigative	[13]
lysophosphatidylinositol	DMETM3R	Discovery agent	N.A.	Investigative	[13]
citral	DM53ZGY	Discovery agent	N.A.	Investigative	[7]
cannabinol	DMM6A7P	Discovery agent	N.A.	Investigative	[14]
TRIM	DMNHU4M	Discovery agent	N.A.	Investigative	[3]

Drug(s) Targeting Transient receptor potential cation channel V1 (TRPV1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[15]
CNTX-4975	DMB4JPG	Knee osteoarthritis	FA01	Phase 3	[16]
XEN-D0501	DMG7PDY	Overactive bladder	GC50.0	Phase 2	[17]
Resiniferatoxin	DMP62L5	Neuropathic pain	8E43.0	Phase 2	[18]
PAC-14028	DM3816P	Atopic dermatitis	EA80	Phase 2	[19]
GRC-15300	DMWXJSZ	Pain	MG30-MG3Z	Phase 2	[20]
DWP-05195	DMQKU2F	Neuropathic pain	8E43.0	Phase 2	[21]
SB-705498	DMRYHWI	Rhinitis	FA20	Phase 2	[22]
GRC-6211	DMZ0D3V	Asthma	CA23	Phase 1	[23]
ABT-102	DMJFWPR	Chronic pain	MG30	Phase 1	[22]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Transient receptor potential cation channel V1 (TRPV1)	TTMI6F5	TRPV1_HUMAN	Activator	[2]
Transient receptor potential cation channel V2 (TRPV2)	TTBECWA	TRPV2_HUMAN	Activator	[3]
Transient receptor potential cation channel V3 (TRPV3)	TT946IA	TRPV3_HUMAN	Activator	[4]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2494).
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 507).
• [3] Pharmacological characterization and molecular determinants of the activation of transient receptor potential V2 channel orthologs by 2-aminoethoxy... Mol Pharmacol. 2007 Nov;72(5):1258-68.
• [4] Biphasic currents evoked by chemical or thermal activation of the heat-gated ion channel, TRPV3. J Biol Chem. 2005 Apr 22;280(16):15928-41.
• [5] Pharmacological profiling of the TRPV3 channel in recombinant and native assays. Br J Pharmacol. 2014 May;171(10):2631-44.
• [6] 2-aminoethoxydiphenyl borate activates and sensitizes the heat-gated ion channel TRPV3. J Neurosci. 2004 Jun 2;24(22):5177-82.
• [7] Citral sensing by Transient [corrected] receptor potential channels in dorsal root ganglion neurons. PLoS One. 2008 May 7;3(5):e2082.
• [8] 17(R)-resolvin D1 specifically inhibits transient receptor potential ion channel vanilloid 3 leading to peripheral antinociception. Br J Pharmacol. 2012 Feb;165(3):683-92.
• [9] Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels. Nat Neurosci. 2006 May;9(5):628-35.
• [10] More than cool: promiscuous relationships of menthol and other sensory compounds. Mol Cell Neurosci. 2006 Aug;32(4):335-43.
• [11] Monoterpenoid agonists of TRPV3. Br J Pharmacol. 2007 Jun;151(4):530-40.
• [12] Cannabinoid actions at TRPV channels: effects on TRPV3 and TRPV4 and their potential relevance to gastrointestinal inflammation. Acta Physiol (Oxf). 2012 Feb;204(2):255-66.
• [13] Lysophospholipids stimulate prostate cancer cell migration via TRPV2 channel activation. Biochim Biophys Acta. 2009 Mar;1793(3):528-39.
• [14] TRPV2 is activated by cannabidiol and mediates CGRP release in cultured rat dorsal root ganglion neurons. J Neurosci. 2008 Jun 11;28(24):6231-8.
• [15] Capsaicin receptor: TRPV1 a promiscuous TRP channel. Handb Exp Pharmacol. 2007;(179):155-71.
• [16] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [17] An investigation of the safety and pharmacokinetics of the novel TRPV1 antagonist XEN-D0501 in healthy subjects. Br J Clin Pharmacol. 2011 Dec;72(6):921-31.
• [18] Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26.
• [19] Development of PAC-14028, a novel transient receptor potential vanilloid type 1 (TRPV1) channel antagonist as a new drug for refractory skin diseases. Arch Pharm Res. 2012 Mar;35(3):393-6.
• [20] The discovery and development of analgesics: new mechanisms, new modalities. J Clin Invest. 2010 November 1; 120(11): 3753-3759.
• [21] TRPV1 Antagonists as Analgesic Agents. The Open Pain Journal, 2013, 6, (Suppl 1: M11), 108-118 .
• [22] Analgesic potential of TRPV1 antagonists. Biochem Pharmacol. 2009 Aug 1;78(3):211-6.
• [23] GRC-6211, a new oral specific TRPV1 antagonist, decreases bladder overactivity and noxious bladder input in cystitis animal models. J Urol. 2009 Jan;181(1):379-86.