General Information of Drug (ID: DMRT13B)

Drug Name
1,4-Dimethylquinolin-2(1H)-one Drug Info
Synonyms
1,4-dimethylquinolin-2(1h)-one; 2584-47-6; 2(1H)-Quinolinone, 1,4-dimethyl-; 1,4-Dimethyl-2(1H)-quinolinone; 1,4-dimethyl-1,2-dihydroquinolin-2-one; UNII-6WT6AG3ZQJ; 6WT6AG3ZQJ; 1,4-dimethyl-2-quinolone; 1,4-dimethylquinolin-2-one; ST019653; Q-101237; 2(1H)-quinolinone,1,4-dimethyl-; NSC108420; NSC 108420; 1,4-DIMETHYL-2(1H)-QUINOLONE; casimiroin analogue, 1d; 1,4-dimethylcarbostyril; 4-methyl-n-methylquinolone; AC1Q6I1L; AC1L3Y4F; KSC497K0B; MLS000764269; CHEMBL60376; SCHEMBL436564; ZINC32147; CTK3J7500; BDBM29215
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
97252
CAS Number
CAS 2584-47-6
TTD Drug ID
DMRT13B

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Drug(s) Targeting Quinone reductase 2 (NQO2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Melatonin DMKWFBT Depression 6A70-6A7Z Approved [2]
NSC-645809 DMPJQZG Breast cancer 2C60-2C65 Phase 2 [3]
Prolarix DMZIQ8G Solid tumour/cancer 2A00-2F9Z Phase 2 [4]
CB1954 DMVP4YK Solid tumour/cancer 2A00-2F9Z Discontinued in Phase 2 [5]
Flavin-Adenine Dinucleotide DM5S4GK Discovery agent N.A. Investigative [5]
2-iodo-melatonin DMSEIUP Discovery agent N.A. Investigative [1]
3,4,5-Trimethoxy-4'-amino-trans-stilbene DMDBOJ5 Discovery agent N.A. Investigative [6]
NSC-645808 DMMBAR3 Discovery agent N.A. Investigative [3]
decynium 22 DMWCTZ7 Discovery agent N.A. Investigative [7]
NSC-106080 DMR6P9S Discovery agent N.A. Investigative [7]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Quinone reductase 2 (NQO2) TTJLP0R NQO2_HUMAN Inhibitor [1]

References

1 Synthesis of casimiroin and optimization of its quinone reductase 2 and aromatase inhibitory activities. J Med Chem. 2009 Apr 9;52(7):1873-84.
2 The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
3 Imidazoacridin-6-ones as novel inhibitors of the quinone oxidoreductase NQO2. Bioorg Med Chem Lett. 2010 May 1;20(9):2832-6.
4 CenterWatch. Drugs in Clinical Trials Database. CenterWatch. 2008.
5 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
6 Design, synthesis, and biological evaluation of resveratrol analogues as aromatase and quinone reductase 2 inhibitors for chemoprevention of cancer. Bioorg Med Chem. 2010 Jul 15;18(14):5352-66.
7 In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6.