General Information of Drug (ID: DMRZBM7)

Drug Name
RANBEZOLID HYDROCHLORIDE Drug Info
Synonyms RBx-7644; N-[3-[3-Fluoro-4-[4-(5-nitrofuran-2-ylmethyl)piperazin-1-yl]phenyl]-2-oxooxazolidin-5(S)-ylmethyl]acetamide monohydrochloride
Indication
Disease Entry ICD 11 Status REF
Bacterial infection 1A00-1C4Z Preclinical [1]
Cross-matching ID
PubChem CID
6918631
TTD Drug ID
DMRZBM7

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [3]
Telithromycin DMZ4P3A Bacterial infection 1A00-1C4Z Approved [4]
Clarithromycin DM4M1SG Acute maxillary sinusitis Approved [5]
Dirithromycin DM0D9YJ Bacterial infection 1A00-1C4Z Approved [6]
Clindamycin DM15HL8 Acne vulgaris ED80 Approved [5]
Zithromax DMN4H2O Syphilis infection 1A6Z Approved [7]
Troleandomycin DMUZNIG Bacterial infection 1A00-1C4Z Approved [8]
Retapamulin DM9JXB7 Impetigo 1B72 Approved [9]
Dalfopristin DM4LTKV Bacterial infection 1A00-1C4Z Approved [10]
Tedizolid DMG2SKR Skin infection 1F28-1G0Z Approved [11]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Bacterial 50S ribosomal RNA (Bact 50S rRNA) TTUWYEA NOUNIPROTAC Modulator [2]

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017411)
2 Mode of Action of Ranbezolid against Staphylococci and Structural Modeling Studies of Its Interaction with Ribosomes . Antimicrob Agents Chemother. 2009 April; 53(4): 1427-1433.
3 A synthetic alanyl-initiator tRNA with initiator tRNA properties as determined by fluorescence measurements: comparison to a synthetic alanyl-elongator tRNA. Nucleic Acids Res. 1991 Oct 25;19(20):5749-54.
4 An examination of the differential sensitivity to ketolide antibiotics in ermB strains of Streptococcus pyogenes and Streptococcus pneumoniae. Curr Microbiol. 2004 Oct;49(4):239-47.
5 Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria. Nature. 2001 Oct 25;413(6858):814-21.
6 Review of macrolides and ketolides: focus on respiratory tract infections. Drugs. 2001;61(4):443-98.
7 The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
8 Depression of colony formation by human thymus-derived lymphocytes with rifampin and other antimicrobial agents. J Infect Dis. 1981 Jun;143(6):832-5.
9 Retapamulin inhibition of translation and 50S ribosomal subunit formation in Staphylococcus aureus cells. Antimicrob Agents Chemother. 2007 Sep;51(9):3385-7.
10 The streptogramin antibiotics: update on their mechanism of action. Expert Opin Investig Drugs. 1998 Apr;7(4):591-9.
11 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81.