Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMS4FG0)

Drug Name

Promegapoietin Drug Info

Synonyms

IL-3/TPO agonist, Searle; IL-3/TPO agonist, University of Maryland

Indication

Disease Entry	ICD 11	Status	REF
Bone marrow transplantation	QB63.6	Terminated	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

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Drug(s) Targeting Thrombopoietin receptor (MPL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[3]
Eltrombopag	DMOGFIX	Thrombocytopenia	3B64	Approved	[4]
Revolade/Promacta	DM8LRU2	Idiopathic thrombocytopenic purpura	3B64.10	Approved	[5]
Lusutrombopag	DMH6IKO	Thrombocytopenia	3B64	Approved	[6]
As-1670542	DMV05SW	Thrombocytopenia	3B64	Approved	[7]
LGD-4665	DM9T8A2	Immune thrombocytopenic purpura	3B64.13	Phase 2	[4]
BVI-007	DM43GPX	Myocardial infarction	BA41-BA43	Phase 1	[7]
NIP-004	DM0PYEQ	Thrombocytopenia	3B64	Phase 1	[8]
RhTPO	DMCV0BZ	Idiopathic thrombocytopenic purpura	3B64.10	Discontinued in Phase 3	[4]
Totrombopag	DM6SUDC	Thrombocytopenia	3B64	Discontinued in Phase 1	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Thrombopoietin receptor (MPL)	TTIHYA4	TPOR_HUMAN	Modulator	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010450)
2	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
3	2008 FDA drug approvals. Nat Rev Drug Discov. 2009 Feb;8(2):93-6.
4	Emerging drugs for idiopathic thrombocytopenic purpura in adults. Expert Opin Emerg Drugs. 2008 Jun;13(2):237-54.
5	Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).
6	2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
7	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1722).
8	A novel nonpeptidyl human c-Mpl activator stimulates human megakaryopoiesis and thrombopoiesis. Blood. 2006 Jun 1;107(11):4300-7.