Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMSKT8G)

Drug Name

Cartazolate Drug Info

Synonyms

CARTAZOLATE; 34966-41-1; UNII-8K93Z46WPY; CHEMBL8184; SQ 65396; 8K93Z46WPY; SQ-65396; Cartazolato; Cartazolatum; Ethyl 4-(butylamino)-1-ethyl-1H-pyrazolo(3,4-b)-pyridine-5-carboxylate; 4-Butylamino-1-ethyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester; Cartazolatum [INN-Latin]; Cartazolate [USAN:INN]; Cartazolato [INN-Spanish]; Ethyl 4-(butylamino)-1-ethyl-1H-pyrazolo[3,4-b]-pyridine-5-carboxylate; NSC 166873; AC1L1WUF; Cartazolate (USAN/INN); SCHEMBL123839; DTXSID20188511; IQNQAOGGWGCROX-UHFFFAOYSA-N; BDBM50098221

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 37015
CAS Number: CAS 34966-41-1
TTD Drug ID: DMSKT8G

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Phosphodiesterase 5A (PDE5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tadalafil	DMJZHT1	Benign prostatic hyperplasia	GA90	Approved	[2]
Udenafil	DM1IQRP	Erectile dysfunction	HA01.1	Approved	[3]
Vardenafil	DMTBGW8	Cystic fibrosis	CA25	Approved	[4]
Dipyridamole	DMXY30O	Atrial fibrillation	BC81.3	Approved	[5]
Papaverine	DMCA9QP	Brain ischaemia	8B1Z	Approved	[6]
Avanafil	DM75CXN	Erectile dysfunction	HA01.1	Approved	[7]
Rhucin	DM3ADGP	Erectile dysfunction	HA01.1	Approved	[8]
ICARIIN	DMOJQGT	N. A.	N. A.	Phase 3	[9]
EXISULIND	DMBY56U	Colorectal cancer	2B91.Z	Phase 3	[10]
PF-489791	DM3C8GQ	Chronic obstructive pulmonary disease	CA22	Phase 2	[11]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Phosphodiesterase 5A (PDE5A)	TTJ0IQB	PDE5A_HUMAN	Inhibitor	[1]

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References

1	Substituted pyrazolopyridines as potent and selective PDE5 inhibitors: potential agents for treatment of erectile dysfunction. J Med Chem. 2001 Mar 29;44(7):1025-7.
2	Pulmonary arterial hypertension: the most devastating vascular complication of systemic sclerosis. Rheumatology (Oxford). 2009 Jun;48 Suppl 3:iii25-31.
3	Increased expression of the nitric oxide synthase gene and protein in corpus cavernosum by repeated dosing of udenafil in a rat model of chemical d... Asian J Androl. 2009 Jul;11(4):435-42.
4	The effect of vardenafil, a potent and highly selective phosphodiesterase-5 inhibitor for the treatment of erectile dysfunction, on the cardiovascular response to exercise in patients with coronary artery disease. J Am Coll Cardiol. 2002 Dec 4;40(11):2006-12.
5	Anti-platelet therapy: phosphodiesterase inhibitors.Br J Clin Pharmacol.2011 Oct;72(4):634-46.
6	Effects of icariin on cGMP-specific PDE5 and cAMP-specific PDE4 activities. Asian J Androl. 2003 Mar;5(1):15-8.
7	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
8	cGMP-hydrolytic activity and its inhibition by sildenafil in normal and failing human and mouse myocardium. J Pharmacol Exp Ther. 2009 Sep;330(3):884-91.
9	Potent inhibition of human phosphodiesterase-5 by icariin derivatives. J Nat Prod. 2008 Sep;71(9):1513-7.
10	Exisulind induction of apoptosis involves guanosine 3',5'-cyclic monophosphate phosphodiesterase inhibition, protein kinase G activation, and attenuated beta-catenin. Cancer Res. 2000 Jul 1;60(13):3338-42.
11	Highlights of the society for medicinesresearch symposium held december 10th 2009 at the national heart and lung institute, London, UK. Drugs of the Future 2010, 35(4): 349-358.