Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMT4K0Z)

Drug Name

L-citrulline Drug Info

Synonyms

L-citrulline; citrulline; 372-75-8; H-cit-oh; delta-Ureidonorvaline; Sitrulline; N5-Carbamoyl-L-ornithine; L-Cytrulline; L(+)-citrulline; N5-(Aminocarbonyl)ornithine; N(delta)-Carbamylornithine; Citrulline, L-; alpha-Amino-delta-ureidovaleric acid; (S)-2-Amino-5-ureidopentanoic acid; N5-carbamoylornithine; d-ureidonorvaline; Ornithine, N5-(aminocarbonyl)-; L-2-Amino-5-ureidovaleric acid; L-Ornithine, N5-(aminocarbonyl)-; L-(+)-Citrulline; 2-Amino-5-ureidovaleric acid; L-citrullin; (2S)-2-amino-5-(carbamoylamino)pentanoic acid

Indication

Disease Entry	ICD 11	Status	REF
Acute lung injury	NB32.3	Phase 3	[1]

Cross-matching ID

PubChem CID: 9750
ChEBI ID: CHEBI:16349
CAS Number: CAS 372-75-8
TTD Drug ID: DMT4K0Z
VARIDT Drug ID: DR00725

Molecule-Related Drug Atlas

Molecule Type:

DTT

DTP

Drug Status:

Investigative Drug(s)

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Drug(s) Targeting G-protein coupled receptor GPCR33 (GPRC6A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-ornithine	DMHKGCM	Discovery agent	N.A.	Investigative	[2]
L-lysine	DMOD5CK	Discovery agent	N.A.	Investigative	[2]
calindol	DMY9P6E	Discovery agent	N.A.	Investigative	[4]
L-serine	DM6WPIS	Pulmonary tuberculosis	1B10.Z	Investigative	[2]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
G-protein coupled receptor GPCR33 (GPRC6A)	TTI1PRE	GPC6A_HUMAN	Agonist	[2]

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Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Glycoprotein-associated amino acid transporter b0, +AT1 (SLC7A9)	DTP7AEQ	BAT1_HUMAN	Substrate	[3]

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References

1	ClinicalTrials.gov (NCT02891837) L-citrulline for Prevention of Sequelae of Acute Lung Injury in Pediatrics Undergoing Cardiopulmonary Bypass for Heart Defects. U.S. National Institutes of Health.
2	Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids. Mol Pharmacol. 2005 Mar;67(3):589-97.
3	Transport characteristics of L-citrulline in renal apical membrane of proximal tubular cells. Biopharm Drug Dispos. 2009 Apr;30(3):126-37.
4	Molecular determinants of non-competitive antagonist binding to the mouse GPRC6A receptor. Cell Calcium. 2009 Nov-Dec;46(5-6):323-32.