Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMT4P7K)

Drug Name	PMID27336223-Compound-12 Drug Info
Cross-matching ID	PubChem CID 135411 ChEBI ID CHEBI:88334 CAS Number CAS 125316-60-1 TTD Drug ID DMT4P7K

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Patented Agent(s)

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Drug(s) Targeting Retinoic acid receptor gamma (RARG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[2]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[3]
Trifarotene	DMOL793	Acne vulgaris	ED80	Approved	[4]
Tazarotene	DM8SMD1	Acne vulgaris	ED80	Approved	[5]
Palovarotene	DMAD2OZ	Fibrodysplasia ossificans progressiva	FB31.1	Approved	[6]
PMID27336223-Compound-13	DMSZLYD	N. A.	N. A.	Patented	[1]
PMID27336223-Compound-14	DMC41MA	N. A.	N. A.	Patented	[1]
PMID27336223-Compound-11	DMBN6KU	N. A.	N. A.	Patented	[1]
PMID27336223-Compound-15	DMIYCFE	N. A.	N. A.	Patented	[1]
PMID27336223-Compound-9	DM6V13W	N. A.	N. A.	Patented	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Retinoic acid receptor gamma (RARG)	TT1Q3IE	RARG_HUMAN	Agonist	[1]

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References

1	Therapeutic use of selective synthetic ligands for retinoic acid receptors: a patent review.Expert Opin Ther Pat. 2016 Aug;26(8):957-71.
2	Targacept active conformation search: a new method for predicting the conformation of a ligand bound to its protein target. J Med Chem. 2004 Dec 30;47(27):6831-9.
3	Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids. Proc Natl Acad Sci U S A. 1993 Jan 1;90(1):30-4.
4	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019
5	Recent developments in receptor-selective retinoids. Curr Pharm Des. 2000 Jun;6(9):919-31.
6	Randomised controlled trial for emphysema with a selective agonist of the gamma-type retinoic acid receptor. Eur Respir J. 2012 Aug;40(2):306-12.