Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMT4USP)

Drug Name

N,N'-Bis(4-Amino-2-Methylquinolin-6-Yl)Urea Drug Info

Synonyms

Aminoquinuride; Surfen; aminokinuride; UNII-08T7936572; 3811-56-1; N,N'-BIS(4-AMINO-2-METHYLQUINOLIN-6-YL)UREA; 1,3-bis(4-amino-2-methylquinolin-6-yl)urea; N,N'-Bis(4-amino-2-methyl-6-quinolinyl)urea; Aminochinurid; 08T7936572; Aminochinuridum; Aminoquinuridum; Aminoquinurida; Aminokinuridum; Aminochincarbamidum; Aminoquin carbamide; NSC12155; Aminoquinuride [INN]; NCGC00013130-04; NCGC00013130-03; 5424-37-3; Aminoquinuridum [INN-Latin]; Aminoquinurida [INN-Spanish]; 1pwp; N,N-Bis(4-aminochinaldyl-6)harnstoff

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 71166
CAS Number: CAS 3811-56-1
TTD Drug ID: DMT4USP

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Bacterial Lethal factor (Bact lef)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
IQ-DAA	DMHP71R	Bacillus anthracis infection	1G40	Phase 1	[2]
GM6001	DM7V9CT	Corneal ulcer	9A76	Discontinued in Phase 2	[1]
Bisindolylmaleimide-I	DMOQJZC	Discovery agent	N.A.	Investigative	[3]
MMI270	DM38N2K	Discovery agent	N.A.	Investigative	[4]
NSC-622445	DME35CB	Discovery agent	N.A.	Investigative	[5]
N-(Sulfanylacetyl)Tyrosylprolylmethioninamide	DMWJDYZ	Discovery agent	N.A.	Investigative	[1]
N-(3,4-dihydroxybenzyl)oleamide	DM67XSW	Discovery agent	N.A.	Investigative	[6]
N-hydroxy-4-(oleamidomethyl)benzamide	DMUSHZK	Discovery agent	N.A.	Investigative	[6]
N-(3,4,5-trihydroxyphenethyl)oleamide	DMQ5USA	Discovery agent	N.A.	Investigative	[7]
N-oleoyl-dopamine	DM1AVCZ	Discovery agent	N.A.	Investigative	[7]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial Lethal factor (Bact lef)	TTIQSC1	LEF_BACAN	Inhibitor	[1]

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References

1	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
2	Anti-toxin antibodies in prophylaxis and treatment of inhalation anthrax.Future Microbiol.2009 Feb;4(1):35-43.
3	Amiodarone and bepridil inhibit anthrax toxin entry into host cells. Antimicrob Agents Chemother. 2007 Jul;51(7):2403-11.
4	The discovery of a potent and selective lethal factor inhibitor for adjunct therapy of anthrax infection. Bioorg Med Chem Lett. 2006 Feb 15;16(4):964-8.
5	Novel small-molecule inhibitors of anthrax lethal factor identified by high-throughput screening. J Med Chem. 2006 Aug 24;49(17):5232-44.
6	Inhibitors of anthrax lethal factor based upon N-oleoyldopamine. Bioorg Med Chem Lett. 2008 Apr 1;18(7):2467-70.
7	Inhibitors of anthrax lethal factor. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4575-8.