Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTAYMR)

• Drug Name: Carboxydichlorofluorescein Drug Info
• Synonyms: 5,6-carboxydichlorofluorescein
• Cross-matching ID:
  PubChem CID: 129670681
  TTD Drug ID: DMTAYMR
  VARIDT Drug ID: DR00365

Molecule-Related Drug Atlas

Drug(s) Transported By Multidrug resistance-associated protein 5 (ABCC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[2]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[2]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[3]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[4]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[5]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[6]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[7]
FLUORESCEIN	DMQTFAO	Ocular disease	1F00.1Z	Approved	[8]
Pemetrexed	DMMX2E6	Central nervous system lymphoma	2B33.5	Approved	[1]
Adenosine	DMM2NSK	Paroxysmal supraventricular tachycardia	BC81.Z	Approved	[9]

Molecular Interaction Atlas of This Drug

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Multidrug resistance-associated protein 5 (ABCC5)	DTYVM24	MRP5_HUMAN	Substrate	[1]

References

• [1] Kinetic validation of the use of carboxydichlorofluorescein as a drug surrogate for MRP5-mediated transport. Eur J Pharm Sci. 2006 Apr;27(5):524-32.
• [2] The human multidrug resistance protein MRP5 transports folates and can mediate cellular resistance against antifolates. Cancer Res. 2005 May 15;65(10):4425-30.
• [3] ATP-binding cassette C transporters in human pancreatic carcinoma cell lines. Upregulation in 5-fluorouracil-resistant cells. Pancreatology. 2009;9(1-2):136-44.
• [4] Celecoxib upregulates multidrug resistance proteins in colon cancer: lack of synergy with standard chemotherapy. Curr Cancer Drug Targets. 2008 Aug;8(5):414-20.
• [5] Overexpression of MRP4 (ABCC4) and MRP5 (ABCC5) confer resistance to the nucleoside analogs cytarabine and troxacitabine, but not gemcitabine. Springerplus. 2014 Dec 13;3:732.
• [6] Cellular export of drugs and signaling molecules by the ATP-binding cassette transporters MRP4 (ABCC4) and MRP5 (ABCC5). Drug Metab Rev. 2005;37(1):253-78.
• [7] Interdependence of gemcitabine treatment, transporter expression, and resistance in human pancreatic carcinoma cells. Neoplasia. 2010 Sep;12(9):740-7.
• [8] Hyaluronan export by the ABC transporter MRP5 and its modulation by intracellular cGMP. J Biol Chem. 2007 Jul 20;282(29):20999-1004.
• [9] Role of MRP4 and MRP5 in biology and chemotherapy. AAPS PharmSci. 2002;4(3):E14.