Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTCR2O)

Drug Name

Tecarfarin Drug Info

Synonyms

ATI-5923

Indication

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

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Drug(s) Targeting Vitamin K epoxide reductase complex 1 (VKORC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Warfarin	DMJYCVW	Atrial fibrillation	BC81.3	Approved	[4]
Acenocoumarol	DMH75KV	Thrombosis	DB61-GB90	Approved	[5]
Phenprocoumon	DMDO279	Myocardial infarction	BA41-BA43	Approved	[4]
Dicumarol	DMFQCB1	Bleeding disorder	GA20-GA21	Approved	[6]
Phenindione	DM2PYNR	Coagulation defect	3B10.0	Approved	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Vitamin K epoxide reductase complex 1 (VKORC1)	TTEUC8H	VKOR1_HUMAN	Inhibitor	[3]

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References

1	ClinicalTrials.gov (NCT02522221) Tecarfarin Anti-Coagulation Trial (TACT).
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	Tecarfarin, a novel vitamin K reductase antagonist, is not affected by CYP2C9 and CYP3A4 inhibition following concomitant administration of fluconazole in healthy participants. J Clin Pharmacol. 2011Apr;51(4):561-74.
4	[Oral anticoagulation and pharmacogenetics: importance in the clinical setting]. Rev Med Suisse. 2007 Sep 12;3(124):2030, 2033-4, 2036.
5	Evaluation of a reverse-hybridization StripAssay for the detection of genetic polymorphisms leading to acenocoumarol sensitivity. Mol Biol Rep. 2010 Apr;37(4):1693-7.
6	Vitamin K antagonism of coumarin intoxication in the rat. Thromb Haemost. 1986 Apr 30;55(2):235-9.