General Information of Drug (ID: DMTJQ8S)

Drug Name
GS-9219 Drug Info
Synonyms PMEG prodrug (cancer), Gilead
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 1/2 [1]
Cross-matching ID
PubChem CID
16047979
CAS Number
CAS 859209-74-8
TTD Drug ID
DMTJQ8S

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [3]
Aciclovir DMYLOVR Genital herpes 1A94 Approved [4]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [5]
Valaciclovir DMHKS94 Genital herpes 1A94 Approved [6]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [4]
Valganciclovir DMS2IUH Virus infection 1A24-1D9Z Approved [7]
Penciclovir DMOUMDV Herpes simplex labialis 1F00.01 Approved [8]
Famciclovir DMJHLSD Meniere disease AB31.0 Approved [9]
Valacyclovir Hydrochloride DM5I1CE Herpes simplex virus infection 1F00 Approved [4]
Foscavir DM9KJLZ Cytomegalovirus retinitis 9B72.00 Approved [7]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Herpes simplex virus DNA polymerase UL30 (HSV UL30) TTIU7X1 DPOL_HHV11 Inhibitor [2]

References

1 ClinicalTrials.gov (NCT00499239) A Trial of GS-9219 in Chronic Lymphocytic Leukemia (CLL), Non-Hodgkin's Lymphoma (NHL) or Multiple Myeloma (MM). U.S. National Institutes of Health.
2 GS-9219--a novel acyclic nucleotide analogue with potent antineoplastic activity in dogs with spontaneous non-Hodgkin's lymphoma. Clin Cancer Res. 2008 May 1;14(9):2824-32.
3 Chromatin-associated proteins HMGB1/2 and PDIA3 trigger cellular response to chemotherapy-induced DNA damage. Mol Cancer Ther. 2009 Apr;8(4):864-72.
4 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
5 Application of real time polymerase chain reaction to the diagnosis and treatment of cytomegalovirus infection after allogeneic hematopoietic stem cell transplantation. Zhonghua Xue Ye Xue Za Zhi. 2009 Feb;30(2):77-81.
6 Extensive oral shedding of human herpesvirus 8 in a renal allograft recipient. Oral Microbiol Immunol. 2009 Apr;24(2):109-15.
7 Drug targets in cytomegalovirus infection. Infect Disord Drug Targets. 2009 Apr;9(2):201-22.
8 Antimicrobial strategies: inhibition of viral polymerases by 3'-hydroxyl nucleosides. Drugs. 2009;69(2):151-66.
9 Penciclovir cream--improved topical treatment for herpes simplex infections. Skin Pharmacol Physiol. 2004 Sep-Oct;17(5):214-8.