General Information of Drug (ID: DMU1XZD)

Drug Name
Erteberel Drug Info
Synonyms LY-500307; SERBA-1; ER beta agonist (BPH), Lilly; Lead estrogen receptor beta agonists (benign prostatic hyperplasia),Eli Lilly
Indication
Disease Entry ICD 11 Status REF
Prostate hyperplasia GA90 Phase 2 [1]
Cross-matching ID
PubChem CID
10286159
CAS Number
CAS 533884-09-2
TTD Drug ID
DMU1XZD

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Conjugated estrogens DMLT0E1 Menopause symptom GA30.0 Approved [3]
Trilostane DMQZ9GF Cushing disease 5A70 Approved [4]
ARZOXIFENE DMOKCVI Breast cancer 2C60-2C65 Approved [5]
Estrogen DMGY0UT Menopause symptom GA30.0 Approved [6]
Premarin/Pravachol DMLSOB7 Hyperlipidaemia 5C80 Phase 3 [7]
MF-101 DM8Z0I3 Hepatitis virus infection 1E50-1E51 Phase 3 [8]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [9]
AUS-131 DMZMSQJ Hot flushes GA30 Phase 2 [10]
ERB-041 DMCEPUA Inflammatory bowel disease DD72 Phase 2 [11]
VG-101 DMAN21O Menopause symptom GA30.0 Phase 1/2 [12]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Estrogen receptor beta (ESR2) TTOM3J0 ESR2_HUMAN Agonist [2]

References

1 ClinicalTrials.gov (NCT01874756) The Efficacy and Safety of a Selective Estrogen Receptor Beta Agonist (LY500307) for Negative Symptoms and Cognitive Impairment Associated With Schizophrenia. U.S. National Institutes of Health.
2 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031986)
3 Differential biochemical and cellular actions of Premarin estrogens: distinct pharmacology of bazedoxifene-conjugated estrogens combination. Mol Endocrinol. 2009 Jan;23(1):74-85.
4 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
5 Benzothiophene selective estrogen receptor modulators with modulated oxidative activity and receptor affinity. J Med Chem. 2007 May 31;50(11):2682-92.
6 Estrogen inhibits the vascular injury response in estrogen receptor beta-deficient female mice. Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):15133-6.
7 Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors. Nat Rev Drug Discov. 2003 Jul;2(7):517-26.
8 MF101, a selective estrogen receptor beta modulator for the treatment of menopausal hot flushes: a phase II clinical trial. Menopause. 2009 May-Jun;16(3):458-65.
9 Company report (Axcentua)
10 S-equol, a potent ligand for estrogen receptor beta, is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial flora. Am J Clin Nutr. 2005 May;81(5):1072-9.
11 Erb-041, an estrogen receptor-beta agonist, inhibits skin photocarcinogenesis in SKH-1 hairless mice by downregulating the WNT signaling pathway. Cancer Prev Res (Phila). 2014 Feb;7(2):186-98.
12 Update on alternative therapies for vulvovaginal atrophy. Patient Prefer Adherence. 2011; 5: 533-536.