Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMU3YXR)

Drug Name

beta-ergocriptine Drug Info

Synonyms

beta-Ergocryptine; beta-Ergokryptine; EINECS 243-728-6; beta-ergocriptine; 5'alpha(S)-sec-Butyl-12'-hydroxy-2'-isopropylergotaman-3',6',18-trione; AC1L4P6P; GTPL988; YYWXOXLDOMRDHW-SGVWFJRMSA-N; PDSP2_001492; AKOS027307800; LS-64294

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 161309
TTD Drug ID: DMU3YXR

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Preclinical Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Dopamine D5 receptor (D5R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Phenyltoloxamine	DMKAEQW	Allergy	4A80-4A85	Approved	[3]
LE-300	DMGJL16	Schizophrenia	6A20	Preclinical	[4]
ZD-3638	DM6M9GC	Schizophrenia	6A20	Terminated	[4]
GMC-283	DMT1RH6	Schizophrenia	6A20	Terminated	[4]
(+/-)-nantenine	DM0L3GE	Discovery agent	N.A.	Investigative	[5]
ISOCLOZAPINE	DM52CPU	Discovery agent	N.A.	Investigative	[6]
FLUMEZAPINE	DMW0HOG	Discovery agent	N.A.	Investigative	[7]
ISOLOXAPINE	DMH1BN4	Discovery agent	N.A.	Investigative	[8]
1-Dibenzo[b,f]oxepin-10-yl-4-methyl-piperazine	DMOL2Y0	Discovery agent	N.A.	Investigative	[6]
1-[3-(2-Benzyl-phenoxy)-propyl]-pyrrolidine	DMD2NXL	Discovery agent	N.A.	Investigative	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dopamine D5 receptor (D5R)	TTS2PH3	DRD5_HUMAN	Agonist	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 988).
2	Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1. Nature. 1991 Apr 18;350(6319):614-9.
3	Dopamine/serotonin receptor ligands. 9. Oxygen-containing midsized heterocyclic ring systems and nonrigidized analogues. A step toward dopamine D5 ... J Med Chem. 2004 Aug 12;47(17):4155-8.
4	The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22.
5	Synthetic studies and pharmacological evaluations on the MDMA ('Ecstasy') antagonist nantenine. Bioorg Med Chem Lett. 2010 Jan 15;20(2):628-31.
6	Affinity of 10-(4-methylpiperazino)dibenz[b,f]oxepins for clozapine and spiroperidol binding sites in rat brain. J Med Chem. 1982 Jul;25(7):855-8.
7	Effects of conformationally restricted 4-piperazinyl-10H-thienobenzodiazepine neuroleptics on central dopaminergic and cholinergic systems. J Med Chem. 1982 Oct;25(10):1133-40.
8	Synthesis of clozapine analogues and their affinity for clozapine and spiroperidol binding sites in rat brain. J Med Chem. 1981 Sep;24(9):1021-6.