Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMU8QD2)

Drug Name

Apramycin Drug Info

Synonyms

AC1O533Z; XZNUGFQTQHRASN-PHTOHMOASA-N

Indication

Disease Entry	ICD 11	Status	REF
Gram-negative bacterial infection	1B74-1G40	Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Bacterial 16S ribosomal RNA (Bact 16S rRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Framycetin	DMF8DNE	Acute liver failure	DB91	Approved	[3]
Oxazolidinones	DMBM47Z	Gram-positive bacterial infection	1B74-1G40	Phase 2	[4]
G418	DMKTJBU	Discovery agent	N.A.	Investigative	[2]
Hygromycin B	DMEZ92A	Discovery agent	N.A.	Investigative	[2]
Ribostamycin	DMXWUHA	Discovery agent	N.A.	Investigative	[2]
Neamine	DMNCU6H	Discovery agent	N.A.	Investigative	[2]
Butirosin B	DMR6GJK	Discovery agent	N.A.	Investigative	[2]
Aminodeoxykanamycin	DM79E2K	Discovery agent	N.A.	Investigative	[2]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial 16S ribosomal RNA (Bact 16S rRNA)	TT38DW5	NOUNIPROTAC	Inhibitor	[2]

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References

1	ClinicalTrials.gov (NCT04105205) First-In-Human Study of Apramycin. U.S. National Institutes of Health.
2	RNA as a target for small molecules. Curr Opin Chem Biol. 2000 Dec;4(6):678-86.
3	Antistaphylococcal activity of gentamicin. Minerva Med. 1975 Dec 8;66(84):4505-26.
4	Ribosomal RNA is the target for oxazolidinones, a novel class of translational inhibitors. RNA. 1999 Jul;5(7):939-46.