Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMUXO3Z)

Drug Name

AUS-131 Drug Info

Synonyms

AUS-131; S-Equol; (-)-(S)-Equol; (-)-Equol; (3S)-3-(4-hydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-7-ol; (3S)-3-(4-hydroxyphenyl)chroman-7-ol; (S)-(-)-4',7-Isoflavandiol; (S)-3,4-Dihydro-3-(4-hydroxyphenyl)-2H-1-benzopyran-7-ol; (S)-3-(4-Hydroxyphenyl)chroman-7-ol; (S)-Equol; 2H-1-Benzopyran-7-ol, 3,4-dihydro-3-(4-hydroxyphenyl)-, (3S)-; 2T6D2HPX7Q; 4',7-Dihydroxyisoflavan; 4',7-Isoflavandiol; 531-95-3; 7,4'-dihydroxyisoflavan; CCRIS 9222; CHEBI:34741; CHEMBL198877; EINECS 208-522-2; Equol; UNII-2T6D2HPX7Q

Indication

Disease Entry	ICD 11	Status	REF
Benign prostatic hyperplasia	GA90	Phase 2	[1]

Cross-matching ID

PubChem CID: 91469
TTD Drug ID: DMUXO3Z
INTEDE Drug ID: DR2443

Molecule-Related Drug Atlas

Molecule Type:

DME

Drug Status:

Approved Drug(s)

Investigative Drug(s)

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Drug(s) Metabolized By Biphenyl dioxygenase (bphC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isoflavone	DM7U58J	Asthma	CA23	Phase 4	[2]
Flavone	DMEQH6J	Discovery agent	N.A.	Investigative	[2]
Flavanone	DMNWIYM	Discovery agent	N.A.	Investigative	[2]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Biphenyl dioxygenase (bphC)^{Main DME}	DEUX61H	BPHC_PSEFK	Substrate	[2]

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References

1	ClinicalTrials.gov (NCT00962390) Efficacy and Safety of S-Equol on Men With Benign Prostatic Hyperplasia
2	Flavonoids biotransformation by bacterial non-heme dioxygenases, biphenyl and naphthalene dioxygenase. Appl Microbiol Biotechnol. 2011 Jul;91(2):219-28.