Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMV03NS)

Drug Name

A-192558 Drug Info

Synonyms

A-192558; UNII-SQ95TK2P11; CHEMBL19309; SQ95TK2P11; 4-Amino-1-(ethyl-isopropyl-carbamoyl)-5-[(2,2,2-trifluoro-acetylamino)-methyl]-pyrrolidine-3-carboxylic acid; BDBM50098745; 341969-96-8; 3-Pyrrolidinecarboxylic acid, 4-amino-1-((ethyl(1-methylethyl)amino)carbonyl)-5-(((2,2,2-trifluoroacetyl)amino)methyl)-, (3R,4R,5S)-; 1-[(Ethylisopropylamino)carbonyl]-2beta-[(trifluoroacetylamino)methyl]-3alpha-aminopyrrolidine-4alpha-carboxylic acid; 3-Pyrrolidinecarboxylic acid, 4-amino-1-((ethyl(1-methylethyl)amino)carbonyl)-5

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 9885589
CAS Number: CAS 341969-96-8
TTD Drug ID: DMV03NS

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Influenza Neuraminidase (Influ NA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Oseltamivir	DMGO72P	Influenza	1E30-1E32	Approved	[2]
Zanamivir	DMFMBZ4	Influenza	1E30-1E32	Approved	[2]
Peramivir	DMNXY5K	Influenza virus infection	1E30-1E32	Approved	[3]
UX-001	DMD2O0L	Hereditary inclusion body myositis	4A41.2	Phase 3	[4]
CS-8958	DM4CSDH	Influenza virus infection	1E30-1E32	Phase 3	[3]
DAS-181	DM0Y8JP	Influenza virus infection	1E30-1E32	Phase 2	[5]
Lactose	DMO4GPK	Discovery agent	N.A.	Phase 1	[4]
GS-3435	DMV7JC6	Influenza virus infection	1E30-1E32	Terminated	[6]
BCX-140	DMBJERO	Influenza virus infection	1E30-1E32	Terminated	[7]
Alpha-D-Mannose	DMF5DLW	Discovery agent	N.A.	Investigative	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Influenza Neuraminidase (Influ NA)	TT50QJ3	NRAM_I33A0	Inhibitor	[1]

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References

1	Antiviral agents active against influenza A viruses. Nat Rev Drug Discov. 2006 Dec;5(12):1015-25.
2	Current and future antiviral therapy of severe seasonal and avian influenza. Antiviral Res. 2008 Apr;78(1):91-102.
3	Developing new antiviral agents for influenza treatment: what does the future hold Clin Infect Dis. 2009 Jan 1;48 Suppl 1:S3-13.
4	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
5	Inhibition of neuraminidase inhibitor-resistant influenza virus by DAS181, a novel sialidase fusion protein. PLoS One. 2009 Nov 6;4(11):e7838.
6	US patent application no. 2010,0081,713, Compositions and methods for treating viral infections.
7	CN patent application no. 104447481, Benzoic acid thiourea anti-influenza virus compounds as well as preparation method and use thereof.