Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMV05SW)

Drug Name

AS-1670542 Drug Info

Synonyms

AVATROMBOPAG; 570406-98-3; AKR-501; UNII-3H8GSZ4SQL; 3H8GSZ4SQL; AKR 501; Avatrombopag [USAN:INN]; Doptelet; AS 1670542; Avatrombopag (USAN/INN); GTPL9953; DTXSID30205667; ZINC72190218; AKOS027323962; CS-3397; HY-13463; FT-0728753; D10306; AS1670542

Indication

Disease Entry	ICD 11	Status	REF
Thrombocytopenia	3B64	Approved	[1]
Idiopathic thrombocytopenic purpura	3B64.10	Phase 3	[2]

Cross-matching ID

PubChem CID: 9852519
CAS Number: CAS 570406-98-3
TTD Drug ID: DMV05SW
ACDINA Drug ID: D00852

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

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Drug(s) Targeting Thrombopoietin receptor (MPL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[4]
Eltrombopag	DMOGFIX	Thrombocytopenia	3B64	Approved	[5]
Lusutrombopag	DMH6IKO	Thrombocytopenia	3B64	Approved	[1]
LGD-4665	DM9T8A2	Immune thrombocytopenic purpura	3B64.13	Phase 2	[5]
BVI-007	DM43GPX	Myocardial infarction	BA41-BA43	Phase 1	[3]
NIP-004	DM0PYEQ	Thrombocytopenia	3B64	Phase 1	[6]
RhTPO	DMCV0BZ	Idiopathic thrombocytopenic purpura	3B64.10	Discontinued in Phase 3	[5]
Totrombopag	DM6SUDC	Thrombocytopenia	3B64	Discontinued in Phase 1	[7]
Promegapoietin	DMS4FG0	Bone marrow transplantation	QB63.6	Terminated	[8]
		N. A.	N. A.		[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Thrombopoietin receptor (MPL)	TTIHYA4	TPOR_HUMAN	Agonist	[3]

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References

1	2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
2	ClinicalTrials.gov (NCT01433978) A Phase 3, Multicenter, Randomized, Double-blind, Active-controlled, Parallel-group Trial With an Open-label Extension Phase to Evaluate the Efficacy and Safety of Oral E5501 Versus Eltrombopag, in Adults With Chronic Immune Thrombocytopenia (Idiopathic Thrombocytopenic Purpura). U.S. National Institutes of Health.
3	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1722).
4	2008 FDA drug approvals. Nat Rev Drug Discov. 2009 Feb;8(2):93-6.
5	Emerging drugs for idiopathic thrombocytopenic purpura in adults. Expert Opin Emerg Drugs. 2008 Jun;13(2):237-54.
6	A novel nonpeptidyl human c-Mpl activator stimulates human megakaryopoiesis and thrombopoiesis. Blood. 2006 Jun 1;107(11):4300-7.
7	Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).
8	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.