Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMV7JC6)

Drug Name

GS-3435 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Influenza virus infection	1E30-1E32	Terminated	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Influenza Neuraminidase (Influ NA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Oseltamivir	DMGO72P	Influenza virus infection	1E30-1E32	Approved	[4]
Zanamivir	DMFMBZ4	Influenza virus infection	1E30-1E32	Approved	[4]
Peramivir	DMNXY5K	Influenza virus infection	1E30-1E32	Approved	[5]
UX-001	DMD2O0L	Hereditary inclusion body myositis	4A41.2	Phase 3	[6]
CS-8958	DM4CSDH	Influenza virus infection	1E30-1E32	Phase 3	[5]
DAS-181	DM0Y8JP	Influenza virus infection	1E30-1E32	Phase 2	[7]
BCX-140	DMBJERO	Influenza virus infection	1E30-1E32	Terminated	[8]
Alpha-D-Mannose	DMF5DLW	Discovery agent	N.A.	Investigative	[6]
Fucose	DMAHMSV	N. A.	N. A.	Investigative	[6]
Apigenin	DMI3491	Discovery agent	N.A.	Investigative	[9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Influenza Neuraminidase (Influ NA)	TT50QJ3	NRAM_I33A0	Modulator	[2] , [3]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005196)
2	US patent application no. 2010,0081,713, Compositions and methods for treating viral infections.
3	Neuraminidase inhibitors: zanamivir and oseltamivir. Ann Pharmacother. 2001 Jan;35(1):57-70.
4	Current and future antiviral therapy of severe seasonal and avian influenza. Antiviral Res. 2008 Apr;78(1):91-102.
5	Developing new antiviral agents for influenza treatment: what does the future hold Clin Infect Dis. 2009 Jan 1;48 Suppl 1:S3-13.
6	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
7	Inhibition of neuraminidase inhibitor-resistant influenza virus by DAS181, a novel sialidase fusion protein. PLoS One. 2009 Nov 6;4(11):e7838.
8	CN patent application no. 104447481, Benzoic acid thiourea anti-influenza virus compounds as well as preparation method and use thereof.
9	Neuraminidase inhibitory activities of flavonols isolated from Rhodiola rosea roots and their in vitro anti-influenza viral activities. Bioorg Med Chem. 2009 Oct 1;17(19):6816-23.