Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMVDIWO)

• Drug Name: CDX-527 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 1	[1]

• Cross-matching ID: TTD Drug ID: DMVDIWO

Molecule-Related Drug Atlas

Drug(s) Targeting Programmed cell death protein 1 (PD-1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nivolumab	DMAB9QE	Melanoma	2C30	Approved	[3]
Tislelizumab	DMGVUO5	Hodgkin lymphoma	2B30	Approved	[4]
MK-3475	DMBYNW0	Melanoma	2C30	Approved	[3]
Pembrolizumab	DMFQEA6	Melanoma	2C30	Approved	[5]
Cemiplimab	DMKMJHE	Cutaneous squamous cell carcinoma	2C30	Approved	[6]
Retifanlimab	DMRKTCP	Neuroendocrine cancer	2B72.1	Approved	[7]
Sintilimab	DMGWR0C	Hodgkin lymphoma	2B30	Approved	[8]
Dostarlimab	DM78NWP	Endometrial cancer	2C76	Approved	[9]
Toripalimab	DMSGA6Z	Demodex blepharitis	1G07	Approved in China	[10]
PDR001	DM53J6B	Melanoma	2C30	Phase 3	[11]

Drug(s) Targeting T-cell activation antigen CD27 (CD27)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Varlilumab	DMQSC5O	Colorectal cancer	2B91.Z	Phase 2	[7]
CDX-1127	DMPVUGE	leukaemia	2A60-2B33	Phase 1	[12]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Programmed cell death protein 1 (PD-1)	TTNBFWK	PDCD1_HUMAN	Inhibitor	[2]
T-cell activation antigen CD27 (CD27)	TTDO1MV	CD27_HUMAN	Activator	[2]

References

• [1] ClinicalTrials.gov (NCT04440943) A Study of the PD-L1xCD27 Bispecific Antibody CDX-527 in Patients With Advanced Malignancies. U.S. National Institutes of Health.
• [2] Development of CDX-527: a bispecific antibody combining PD-1 blockade and CD27 costimulation for cancer immunotherapy. Cancer Immunol Immunother. 2020 Oct;69(10):2125-2137.
• [3] 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81.
• [4] Tislelizumab: an investigational anti-PD-1 antibody for the treatment of advanced non-small cell lung cancer (NSCLC). Expert Opin Investig Drugs. 2020 Dec;29(12):1355-1364.
• [5] Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730.
• [6] 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
• [7] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [8] Sintilimab: First Global Approval. Drugs. 2019 Feb;79(3):341-346.
• [9] Dostarlimab in the treatment of recurrent or primary advanced endometrial cancer. Future Oncol. 2021 Mar;17(8):877-892.
• [10] Toripalimab: the First Domestic Anti-Tumor PD-1 Antibody in China. Front Immunol. 2022 Jan 12;12:730666.
• [11] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [12] Clinical pipeline report, company report or official report of Celldex Therapeutics.