Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMVMQ1L)

Drug Name

Nafronyl Drug Info

Synonyms

Nafronyl oxalate; 3200-06-4; Naftidrofuryl oxalate; Nafronyl oxalate salt; 2-(Diethylamino)ethyl 3-(naphthalen-1-yl)-2-((tetrahydrofuran-2-yl)methyl)propanoate oxalate; Naftidrofuryl (oxalate); Dusodril; Dubimax; Praxilene; Iridus; LS-121; EU-1806; DSSTox_RID_80935; DSSTox_CID_25533; DSSTox_GSID_45533; naftidrofuryl hydrogen oxalate; CHEMBL1439099; alpha-[1-Naphthylmethyl]-2-tetrahydrofuranpropionic acid diethylaminoethyl ester; SMR000539007; Nafronyl oxalate salt, analytical standard; CAS-3200-06-4; NSC225233; LS 121

Indication

Disease Entry	ICD 11	Status	REF
Cerebrovascular ischaemia	8B1Z	Approved	[1]

Cross-matching ID

PubChem CID: 4417
ChEBI ID: CHEBI:91817
CAS Number: CAS 31329-57-4
TTD Drug ID: DMVMQ1L
INTEDE Drug ID: DR2473

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting 5-HT receptor (5HTR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metergolin	DMJFP6G	Hyperprolactinaemia	5A60.1	Approved	[3]
Paliperidone	DM7NPJS	Psychotic disorder	6A20-6A25	Approved	[1]
Ramosetron	DMH7GN8	Diarrhea-predominant irritable bowel syndrome	DD91.01	Approved	[3]
Pizotyline	DMV74ZH	Headache	8A80-8A84	Approved	[1]
Tandospirone	DMPHWU6	Anxiety disorder	6B00-6B0Z	Approved	[3]
ITI-007	DMUQ1DO	Depression	6A70-6A7Z	Phase 3	[4]
Fenfluramine	DM0762O	Dravet syndrome	8A61.11	Phase 3	[5]
MIN-117	DMSLIW6	Major depressive disorder	6A70.3	Phase 2	[4]
Lu-AA34893	DM2ZUXK	Anxiety disorder	6B00-6B0Z	Phase 2	[6]
SEP--4199	DMA12HB	Bipolar disorder	6A60	Phase 2	[7]
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Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[2]
Vidarabine	DM0N85H	Hepatosplenic T-cell lymphoma		Approved	[2]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[8]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[9]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[10]
Etidronic acid	DM1XHYJ	Bone Paget disease		Approved	[2]
Tiaprofenic acid	DM23D7J	Osteoarthritis	FA00-FA05	Approved	[2]
Bromperidol	DM24XYQ	Schizophrenia	6A20	Approved	[2]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[11]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[12]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT receptor (5HTR)	TT85JO3	NOUNIPROTAC	Modulator	[1]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Nuclear receptor subfamily 1 group I member 2 (NR1I2)	OTC5U0N5	NR1I2_HUMAN	Gene/Protein Processing	[2]

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References

1	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2	Screening of a chemical library reveals novel PXR-activating pharmacologic compounds. Toxicol Lett. 2015 Jan 5;232(1):193-202. doi: 10.1016/j.toxlet.2014.10.009. Epub 2014 Oct 16.
3	Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77.
4	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5	Pharmacotherapy for obesity. Drugs. 2005;65(10):1391-418.
6	Encyclopedia of Psychopharmacology. Ian Stolerman. 2010. Page(105).
7	ClinicalTrials.gov (NCT03543410) A Clinical Study to Test the Effectiveness of an Investigational Drug to Treat People That Have Major Depressive Episodes When They Have Bipolar 1 Depression. U.S. National Institutes of Health.
8	Induction of PXR-mediated metabolism by beta-carotene. Biochim Biophys Acta. 2005 May 30;1740(2):162-9. doi: 10.1016/j.bbadis.2004.11.013. Epub 2004 Dec 8.
9	Lignans, bacteriocides and organochlorine compounds activate the human pregnane X receptor (PXR). Toxicol Appl Pharmacol. 2005 Dec 1;209(2):123-33. doi: 10.1016/j.taap.2005.03.015.
10	Identification and validation of novel human pregnane X receptor activators among prescribed drugs via ligand-based virtual screening. Drug Metab Dispos. 2011 Feb;39(2):337-44. doi: 10.1124/dmd.110.035808. Epub 2010 Nov 10.
11	Identification of HMG-CoA reductase inhibitors as activators for human, mouse and rat constitutive androstane receptor. Drug Metab Dispos. 2005 Jul;33(7):924-9.
12	Acetylated deoxycholic (DCA) and cholic (CA) acids are potent ligands of pregnane X (PXR) receptor. Toxicol Lett. 2017 Jan 4;265:86-96.