General Information of Drug Off-Target (DOT) (ID: OTC5U0N5)

DOT Name Nuclear receptor subfamily 1 group I member 2 (NR1I2)
Synonyms Orphan nuclear receptor PAR1; Orphan nuclear receptor PXR; Pregnane X receptor; Steroid and xenobiotic receptor; SXR
Gene Name NR1I2
UniProt ID
NR1I2_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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PDB ID
1ILG ; 1ILH ; 1M13 ; 1NRL ; 1SKX ; 2O9I ; 2QNV ; 3CTB ; 3HVL ; 3R8D ; 4J5W ; 4J5X ; 4NY9 ; 4S0S ; 4S0T ; 4X1F ; 4X1G ; 4XAO ; 4XHD ; 5A86 ; 5X0R ; 6BNS ; 6DUP ; 6HJ2 ; 6HTY ; 6NX1 ; 6P2B ; 6S41 ; 6TFI ; 6XP9 ; 7AX8 ; 7AX9 ; 7AXA ; 7AXB ; 7AXC ; 7AXD ; 7AXE ; 7AXF ; 7AXG ; 7AXH ; 7AXI ; 7AXJ ; 7AXK ; 7AXL ; 7N2A ; 7RIO ; 7RIU ; 7RIV ; 7YFK ; 8E3N ; 8EQZ ; 8FPE ; 8SZV
Pfam ID
PF00104 ; PF00105
Sequence
MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEG
CKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEE
RRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSS
GCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLL
PHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWE
CGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHR
VVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPF
ATPLMQELFGITGS
Function
Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes.
Tissue Specificity Expressed in liver, colon and small intestine.
Reactome Pathway
(Name not found )
Nuclear Receptor transcription pathway (R-HSA-383280 )

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
This DOT Affected the Drug Response of 1 Drug(s)
Drug Name Drug ID Highest Status Interaction REF
Bisphenol A DM2ZLD7 Investigative Nuclear receptor subfamily 1 group I member 2 (NR1I2) increases the response to substance of Bisphenol A. [47]
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1 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Valproate DMCFE9I Approved Valproate decreases the methylation of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [1]
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96 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Ciclosporin DMAZJFX Approved Ciclosporin decreases the expression of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [2]
Tretinoin DM49DUI Approved Tretinoin increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [3]
Acetaminophen DMUIE76 Approved Acetaminophen decreases the expression of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [4]
Cupric Sulfate DMP0NFQ Approved Cupric Sulfate increases the expression of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [5]
Cisplatin DMRHGI9 Approved Cisplatin increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [6]
Estradiol DMUNTE3 Approved Estradiol increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [6]
Quercetin DM3NC4M Approved Quercetin increases the expression of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [7]
Calcitriol DM8ZVJ7 Approved Calcitriol increases the expression of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [8]
Triclosan DMZUR4N Approved Triclosan decreases the expression of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [9]
Carbamazepine DMZOLBI Approved Carbamazepine increases the expression of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [10]
Decitabine DMQL8XJ Approved Decitabine increases the expression of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [11]
Phenobarbital DMXZOCG Approved Phenobarbital increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [12]
Progesterone DMUY35B Approved Progesterone increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [6]
Fulvestrant DM0YZC6 Approved Fulvestrant increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [13]
Dexamethasone DMMWZET Approved Dexamethasone increases the expression of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [14]
Isotretinoin DM4QTBN Approved Isotretinoin increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [3]
Ethanol DMDRQZU Approved Ethanol increases the expression of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [16]
Etoposide DMNH3PG Approved Etoposide increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [3]
Paclitaxel DMLB81S Approved Paclitaxel increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [12]
Diclofenac DMPIHLS Approved Diclofenac increases the expression of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [17]
Permethrin DMZ0Q1G Approved Permethrin increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [18]
Ethinyl estradiol DMODJ40 Approved Ethinyl estradiol increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [19]
Simvastatin DM30SGU Approved Simvastatin increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [20]
Rifampicin DM5DSFZ Approved Rifampicin increases the expression of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [21]
Cyclophosphamide DM4O2Z7 Approved Cyclophosphamide increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [22]
Mifepristone DMGZQEF Approved Mifepristone increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [23]
Ifosfamide DMCT3I8 Approved Ifosfamide increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [22]
Vinblastine DM5TVS3 Approved Vinblastine increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [22]
Clorgyline DMCEUJD Approved Clorgyline increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [3]
Thalidomide DM70BU5 Approved Thalidomide increases the expression of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [24]
Lindane DMB8CNL Approved Lindane increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [25]
Phenytoin DMNOKBV Approved Phenytoin increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [12]
Ursodeoxycholic acid DMCUT21 Approved Ursodeoxycholic acid increases the expression of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [26]
Beta-carotene DM0RXBT Approved Beta-carotene increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [27]
Nefazodone DM4ZS8M Approved Nefazodone decreases the expression of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [28]
Chenodiol DMQ8JIK Approved Chenodiol increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [29]
Docetaxel DMDI269 Approved Docetaxel increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [22]
Cholecalciferol DMGU74E Approved Cholecalciferol increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [13]
Deoxycholic acid DM3GYAL Approved Deoxycholic acid increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [29]
Warfarin DMJYCVW Approved Warfarin decreases the expression of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [30]
Orlistat DMRJSP8 Approved Orlistat increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [31]
Aminoglutethimide DMWFHMZ Approved Aminoglutethimide increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [32]
Atazanavir DMSYRBX Approved Atazanavir decreases the expression of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [28]
Omeprazole DM471KJ Approved Omeprazole increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [25]
Cimetidine DMH61ZB Approved Cimetidine decreases the expression of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [33]
Hesperetin DMKER83 Approved Hesperetin increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [3]
Mitotane DMU1GX0 Approved Mitotane increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [34]
Clotrimazole DMMFCIH Approved Clotrimazole increases the expression of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [35]
Propranolol DM79NTF Approved Propranolol increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [19]
Flutamide DMK0O7U Approved Flutamide increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [22]
Mefenamic acid DMK7HFI Approved Mefenamic acid increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [36]
Budesonide DMJIBAW Approved Budesonide increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [3]
Methoxsalen DME8FZ9 Approved Methoxsalen increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [37]
Lidocaine DML4ZOT Approved Lidocaine increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [3]
Lansoprazole DMXYLQ3 Approved Lansoprazole increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [3]
Cholic acid DM7OKQV Approved Cholic acid increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [29]
Felodipine DMOSW35 Approved Felodipine increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [38]
Miconazole DMPMYE8 Approved Miconazole decreases the expression of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [39]
Fluticasone propionate DMRWLB2 Approved Fluticasone propionate increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [32]
Riluzole DMECBWN Approved Riluzole increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [3]
Glimepiride DM5FSJA Approved Glimepiride increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [3]
Topiramate DM82Z30 Approved Topiramate increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [40]
Isradipine DMA5XGH Approved Isradipine increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [38]
Procaine DM4LSNE Approved Procaine increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [3]
Phenoxybenzamine DM8KSQH Approved Phenoxybenzamine increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [34]
Disopyramide DM5SYZP Approved Disopyramide increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [3]
Itraconazole DMCR1MV Approved Itraconazole increases the expression of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [35]
Metyrapone DMI7FVQ Approved Metyrapone increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [41]
Nimodipine DMQ0RKZ Approved Nimodipine increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [32]
Midazolam DMXOELT Approved Midazolam increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [42]
Thiabendazole DM7YCK3 Approved Thiabendazole increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [3]
Oxybuprocaine DMI0GDH Approved Oxybuprocaine increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [3]
Sulfinpyrazone DMEV954 Approved Sulfinpyrazone increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [12]
Trifluridine DMG2YBD Approved Trifluridine increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [3]
Megestrol DMDH9KX Approved Megestrol increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [32]
Finasteride DMWV3TZ Approved Finasteride increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [32]
Dicloxacillin DM8EU0Z Approved Dicloxacillin increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [3]
Nabumetone DMAT2XH Approved Nabumetone increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [3]
Secobarbital DM14RF5 Approved Secobarbital increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [32]
Tiaprofenic acid DM23D7J Approved Tiaprofenic acid increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [3]
Bromperidol DM24XYQ Approved Bromperidol increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [3]
Metolazone DMB39LO Approved Metolazone increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [3]
Dibucaine DMF9G7L Approved Dibucaine increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [3]
Nafcillin DMN9RPO Approved Nafcillin increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [3]
Sulfamethazine DMRGZ16 Approved Sulfamethazine increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [12]
Rifaximin DMW1TV2 Approved Rifaximin increases the expression of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [44]
Flunisolide DMZSWQC Approved Flunisolide increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [32]
Monobenzone DMVJS2K Approved Monobenzone increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [3]
Vidarabine DM0N85H Approved Vidarabine increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [3]
Etidronic acid DM1XHYJ Approved Etidronic acid increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [3]
Idoxuridine DMDRT0E Approved Idoxuridine increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [3]
Imipenem DMI9FBP Approved Imipenem increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [3]
Isoetharine DMITSEH Approved Isoetharine increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [3]
Nafronyl DMVMQ1L Approved Nafronyl increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [3]
Urethane DM7NSI0 Phase 4 Urethane decreases the expression of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [45]
Berberine DMC5Q8X Phase 4 Berberine increases the activity of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [46]
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⏷ Show the Full List of 96 Drug(s)
3 Drug(s) Affected the Protein Interaction/Cellular Processes of This DOT
Drug Name Drug ID Highest Status Interaction REF
Rosiglitazone DMILWZR Approved Rosiglitazone affects the localization of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [15]
Pioglitazone DMKJ485 Approved Pioglitazone affects the localization of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [15]
Pimecrolimus DMZLGRB Approved Pimecrolimus affects the binding of Nuclear receptor subfamily 1 group I member 2 (NR1I2). [43]
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