Details of the Drug

General Information of Drug (ID: DM14RF5)

Drug Name
Secobarbital
Synonyms
Barbosec; Evronal; Hypotrol; Hyptran; Meballymal; Meballymalum; Pramil; Quinalbarbital; Quinalbarbitone; Secobarbitale; Secobarbitalum; Secobarbitone; Seconal; Seotal; Somosal; Secobarbital solution; Secobarbital suppository dosage form; Secobarbitale [DCIT]; Secobarbital [USAN:INN]; Secobarbitalum [INN-Latin]; Seconal (TN);Secobarbital (USP/INN); (+-)-5-Allyl-5-(1-methylbutyl)-barbituric acid; (+-)-Secobarbital; 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-(1-methylbutyl)-5-(2-propenyl)-, (+-)-(9CI); 5-(1-methylbutyl)-5-(2-propenyl)-2,4,6(1H,3H,5H)-pyrimidinetrione; 5-(pentan-2-yl)-5-(prop-2-en-1-yl)-pyrimidine-2,4,6(1H,3H,5H)-trione; 5-ALLYL-5-(1-METHYLBUTYL)BARBITURIC ACID; 5-Allyl-5-(1-methylbutyl)-2,4,6(1H,3H,5H)-pyrimidinetrione; 5-Allyl-5-(1-methylbutyl)barbiturate; 5-Allyl-5-(1-methylbutyl)malonylurea; 5-allyl-5-(1-methylbutyl)pyrimidine-2,4,6(1H,3H,5H)-trione; 5-pentan-2-yl-5-prop-2-enyl-1,3-diazinane-2,4,6-trione
Indication
Disease Entry ICD 11 Status REF
Epilepsy 8A60-8A68 Approved [1]
Insomnia 7A00-7A0Z Approved [1]
Intractable insomnia 7A00 Approved [2]
Therapeutic Class
Hypnotics and Sedatives
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 238.28
Logarithm of the Partition Coefficient (xlogp) 2
Rotatable Bond Count (rotbonds) 5
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 3
ADMET Property
BDDCS Class
Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 1: high solubility and high permeability [3]
MRTD
The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 10.96673 micromolar/kg/day [4]
Water Solubility
The ability of drug to dissolve in water is measured as 1.1 mg/mL [3]
Chemical Identifiers
Formula
C12H18N2O3
IUPAC Name
5-pentan-2-yl-5-prop-2-enyl-1,3-diazinane-2,4,6-trione
Canonical SMILES
CCCC(C)C1(C(=O)NC(=O)NC1=O)CC=C
InChI
InChI=1S/C12H18N2O3/c1-4-6-8(3)12(7-5-2)9(15)13-11(17)14-10(12)16/h5,8H,2,4,6-7H2,1,3H3,(H2,13,14,15,16,17)
InChIKey
KQPKPCNLIDLUMF-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
5193
ChEBI ID
CHEBI:9073
CAS Number
76-73-3
DrugBank ID
DB00418
TTD ID
D00SJE
ACDINA ID
D00617
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
GABA(A) receptor alpha-1 (GABRA1) TT1MPAY GBRA1_HUMAN Antagonist [5]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Post-Translational Modifications [6]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Post-Translational Modifications [6]
Nuclear receptor subfamily 1 group I member 2 (NR1I2) OTC5U0N5 NR1I2_HUMAN Gene/Protein Processing [7]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Secobarbital (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Repaglinide DM5SXUV Moderate Increased metabolism of Secobarbital caused by Repaglinide mediated induction of CYP450 enzyme. Acute diabete complication [5A2Y] [8]
Midostaurin DMI6E0R Moderate Increased metabolism of Secobarbital caused by Midostaurin mediated induction of CYP450 enzyme. Acute myeloid leukaemia [2A60] [9]
Gilteritinib DMTI0ZO Moderate Increased metabolism of Secobarbital caused by Gilteritinib mediated induction of CYP450 enzyme. Acute myeloid leukaemia [2A60] [10]
Oliceridine DM6MDCF Major Additive CNS depression effects by the combination of Secobarbital and Oliceridine. Acute pain [MG31] [11]
Mitotane DMU1GX0 Minor Increased metabolism of Secobarbital caused by Mitotane mediated induction of CYP450 enzyme. Adrenal cancer [2D11] [12]
Donepezil DMIYG7Z Moderate Increased metabolism of Secobarbital caused by Donepezil mediated induction of CYP450 enzyme. Alzheimer disease [8A20] [13]
Ivabradine DM0L594 Moderate Increased metabolism of Secobarbital caused by Ivabradine mediated induction of CYP450 enzyme. Angina pectoris [BA40] [14]
Dronedarone DMA8FS5 Moderate Increased metabolism of Secobarbital caused by Dronedarone mediated induction of CYP450 enzyme. Angina pectoris [BA40] [15]
Nifedipine DMSVOZT Moderate Increased metabolism of Secobarbital caused by Nifedipine mediated induction of CYP450 enzyme. Angina pectoris [BA40] [16]
Bedaquiline DM3906J Moderate Increased metabolism of Secobarbital caused by Bedaquiline mediated induction of CYP450 enzyme. Antimicrobial drug resistance [MG50-MG52] [17]
Buspirone DMBS632 Moderate Increased metabolism of Secobarbital caused by Buspirone mediated induction of CYP450 enzyme. Anxiety disorder [6B00-6B0Z] [18]
Voriconazole DMAOL2S Moderate Increased metabolism of Secobarbital caused by Voriconazole mediated induction of CYP450 enzyme. Aspergillosis [1F20] [19]
Aminophylline DML2NIB Moderate Increased metabolism of Secobarbital caused by Aminophylline mediated induction of CYP450 enzyme. Asthma [CA23] [20]
Tindamax DM3OWT4 Moderate Increased metabolism of Secobarbital caused by Tindamax mediated induction of CYP450 enzyme. Bacterial infection [1A00-1C4Z] [21]
Chloramphenicol DMFXEWT Moderate Decreased metabolism of Secobarbital caused by Chloramphenicol mediated inhibition of CYP450 enzyme. Bacterial infection [1A00-1C4Z] [22]
Telithromycin DMZ4P3A Moderate Increased metabolism of Secobarbital caused by Telithromycin mediated induction of CYP450 enzyme. Bacterial infection [1A00-1C4Z] [23]
Ixabepilone DM2OZ3G Moderate Increased metabolism of Secobarbital caused by Ixabepilone mediated induction of CYP450 enzyme. Breast cancer [2C60-2C6Y] [24]
Lapatinib DM3BH1Y Moderate Increased metabolism of Secobarbital caused by Lapatinib mediated induction of CYP450 enzyme. Breast cancer [2C60-2C6Y] [25]
LY2835219 DM93VBZ Moderate Increased metabolism of Secobarbital caused by LY2835219 mediated induction of CYP450 enzyme. Breast cancer [2C60-2C6Y] [26]
Exemestane DM9HPW3 Moderate Increased metabolism of Secobarbital caused by Exemestane mediated induction of CYP450 enzyme. Breast cancer [2C60-2C6Y] [27]
Esterified estrogens DM9KZDO Moderate Increased metabolism of Secobarbital caused by Esterified estrogens mediated induction of CYP450 enzyme. Breast cancer [2C60-2C6Y] [28]
Tucatinib DMBESUA Moderate Increased metabolism of Secobarbital caused by Tucatinib mediated induction of CYP450 enzyme. Breast cancer [2C60-2C6Y] [23]
Palbociclib DMD7L94 Moderate Increased metabolism of Secobarbital caused by Palbociclib mediated induction of CYP450 enzyme. Breast cancer [2C60-2C6Y] [25]
Alpelisib DMEXMYK Moderate Increased metabolism of Secobarbital caused by Alpelisib mediated induction of CYP450 enzyme. Breast cancer [2C60-2C6Y] [29]
Quinestrol DMJ6H1Z Moderate Increased metabolism of Secobarbital caused by Quinestrol mediated induction of CYP450 enzyme. Breast cancer [2C60-2C6Y] [30]
Tamoxifen DMLB0EZ Moderate Increased metabolism of Secobarbital caused by Tamoxifen mediated induction of CYP450 enzyme. Breast cancer [2C60-2C6Y] [31]
Cabazitaxel DMPAZHC Moderate Increased metabolism of Secobarbital caused by Cabazitaxel mediated induction of CYP450 enzyme. Breast cancer [2C60-2C6Y] [32]
Toremifene DMQYUWG Moderate Increased metabolism of Secobarbital caused by Toremifene mediated induction of CYP450 enzyme. Breast cancer [2C60-2C6Y] [33]
Bosutinib DMTI8YE Moderate Increased metabolism of Secobarbital caused by Bosutinib mediated induction of CYP450 enzyme. Breast cancer [2C60-2C6Y] [34]
Estradiol DMUNTE3 Moderate Increased metabolism of Secobarbital caused by Estradiol mediated induction of CYP450 enzyme. Breast cancer [2C60-2C6Y] [30]
Atorvastatin DMF28YC Moderate Increased metabolism of Secobarbital caused by Atorvastatin mediated induction of CYP450 enzyme. Cardiovascular disease [BA00-BE2Z] [35]
Macitentan DMP79A1 Moderate Increased metabolism of Secobarbital caused by Macitentan mediated induction of CYP450 enzyme. Cardiovascular disease [BA00-BE2Z] [36]
Corticotropin DMP9TWZ Moderate Increased metabolism of Secobarbital caused by Corticotropin mediated induction of CYP450 enzyme. Chronic kidney disease [GB61] [37]
PF-04449913 DMSB068 Moderate Increased metabolism of Secobarbital caused by PF-04449913 mediated induction of CYP450 enzyme. Chronic myelomonocytic leukaemia [2A40] [38]
Dihydrocodeine DMB0FWL Major Additive CNS depression effects by the combination of Secobarbital and Dihydrocodeine. Chronic pain [MG30] [39]
Anisindione DM2C48U Major Increased metabolism of Secobarbital caused by Anisindione mediated induction of CYP450 enzyme. Coagulation defect [3B10] [40]
Irinotecan DMP6SC2 Moderate Increased metabolism of Secobarbital caused by Irinotecan mediated induction of CYP450 enzyme. Colorectal cancer [2B91] [41]
Olopatadine DMKMWQG Moderate Additive CNS depression effects by the combination of Secobarbital and Olopatadine. Conjunctiva disorder [9A60] [42]
Drospirenone DM1A9W3 Moderate Increased metabolism of Secobarbital caused by Drospirenone mediated induction of CYP450 enzyme. Contraceptive management [QA21] [28]
Levonorgestrel DM1DP7T Moderate Increased metabolism of Secobarbital caused by Levonorgestrel mediated induction of CYP450 enzyme. Contraceptive management [QA21] [30]
Ulipristal DMBNI20 Moderate Increased metabolism of Secobarbital caused by Ulipristal mediated induction of CYP450 enzyme. Contraceptive management [QA21] [14]
Levobupivacaine DM783CH Minor Increased metabolism of Secobarbital caused by Levobupivacaine mediated induction of CYP450 enzyme. Corneal disease [9A76-9A78] [43]
Propofol DMB4OLE Moderate Additive CNS depression effects by the combination of Secobarbital and Propofol. Corneal disease [9A76-9A78] [44]
Methoxyflurane DML0RAE Moderate Increased metabolism of Secobarbital caused by Methoxyflurane mediated induction of CYP450 enzyme. Corneal disease [9A76-9A78] [45]
Alfentanil DMVO0UB Major Additive CNS depression effects by the combination of Secobarbital and Alfentanil. Corneal disease [9A76-9A78] [46]
Remifentanil DMZTXCH Major Additive CNS depression effects by the combination of Secobarbital and Remifentanil. Corneal disease [9A76-9A78] [46]
Oxtriphylline DMLHSE3 Moderate Increased metabolism of Secobarbital caused by Oxtriphylline mediated induction of CYP450 enzyme. Cough [MD12] [20]
Mifepristone DMGZQEF Moderate Increased metabolism of Secobarbital caused by Mifepristone mediated induction of CYP450 enzyme. Cushing syndrome [5A70] [47]
Osilodrostat DMIJC9X Moderate Increased metabolism of Secobarbital caused by Osilodrostat mediated induction of CYP450 enzyme. Cushing syndrome [5A70] [23]
Ivacaftor DMZC1HS Moderate Increased metabolism of Secobarbital caused by Ivacaftor mediated induction of CYP450 enzyme. Cystic fibrosis [CA25] [48]
Ethanol DMDRQZU Major Additive CNS depression effects by the combination of Secobarbital and Ethanol. Cystitis [GC00] [49]
Rivaroxaban DMQMBZ1 Moderate Increased metabolism of Secobarbital caused by Rivaroxaban mediated induction of CYP450 enzyme. Deep vein thrombosis [BD71] [50]
Aprepitant DM053KT Moderate Increased metabolism of Secobarbital caused by Aprepitant mediated induction of CYP450 enzyme. Depression [6A70-6A7Z] [51]
Fluoxetine DM3PD2C Minor Decreased metabolism of Secobarbital caused by Fluoxetine mediated inhibition of CYP450 enzyme. Depression [6A70-6A7Z] [52]
Vilazodone DM4LECQ Moderate Increased metabolism of Secobarbital caused by Vilazodone mediated induction of CYP450 enzyme. Depression [6A70-6A7Z] [53]
Paroxetine DM5PVQE Minor Increased metabolism of Secobarbital caused by Paroxetine mediated induction of CYP450 enzyme. Depression [6A70-6A7Z] [54]
Vortioxetine DM6F1PU Moderate Increased metabolism of Secobarbital caused by Vortioxetine mediated induction of CYP450 enzyme. Depression [6A70-6A7Z] [55]
Esketamine DMVU687 Moderate Additive CNS depression effects by the combination of Secobarbital and Esketamine. Depression [6A70-6A7Z] [25]
[3H]estrone-3-sulphate DMGPF0N Moderate Increased metabolism of Secobarbital caused by [3H]estrone-3-sulphate mediated induction of CYP450 enzyme. Discovery agent [N.A.] [30]
Zonisamide DM0DTF7 Moderate Increased metabolism of Secobarbital caused by Zonisamide mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [56]
Stiripentol DMMSDOY Moderate Increased metabolism of Secobarbital caused by Stiripentol mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [14]
Fosphenytoin DMOX3LB Moderate Increased metabolism of Secobarbital caused by Fosphenytoin mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [57]
Carbamazepine DMZOLBI Minor Increased metabolism of Secobarbital caused by Carbamazepine mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [58]
Nicardipine DMCDYW7 Moderate Increased metabolism of Secobarbital caused by Nicardipine mediated induction of CYP450 enzyme. Essential hypertension [BA00] [16]
Praziquantel DMOU1PK Moderate Increased metabolism of Secobarbital caused by Praziquantel mediated induction of CYP450 enzyme. Flatworm infection [1F70-1F86] [59]
Bay 80-6946 DMLOS5R Moderate Increased metabolism of Secobarbital caused by Bay 80-6946 mediated induction of CYP450 enzyme. Follicular lymphoma [2A80] [60]
Tazemetostat DMWP1BH Moderate Increased metabolism of Secobarbital caused by Tazemetostat mediated induction of CYP450 enzyme. Follicular lymphoma [2A80] [61]
Solifenacin DMG592Q Moderate Increased metabolism of Secobarbital caused by Solifenacin mediated induction of CYP450 enzyme. Functional bladder disorder [GC50] [62]
Mirabegron DMS1GYT Minor Increased metabolism of Secobarbital caused by Mirabegron mediated induction of CYP450 enzyme. Functional bladder disorder [GC50] [63]
Darifenacin DMWXLYZ Moderate Increased metabolism of Secobarbital caused by Darifenacin mediated induction of CYP450 enzyme. Functional bladder disorder [GC50] [64]
Caspofungin DMGQIPT Moderate Increased metabolism of Secobarbital caused by Caspofungin mediated induction of CYP450 enzyme. Fungal infection [1F29-1F2F] [65]
Cimetidine DMH61ZB Minor Altered absorption of Secobarbital caused by Cimetidine. Gastro-oesophageal reflux disease [DA22] [66]
Ripretinib DM958QB Moderate Increased metabolism of Secobarbital caused by Ripretinib mediated induction of CYP450 enzyme. Gastrointestinal stromal tumour [2B5B] [25]
Sunitinib DMCBJSR Moderate Increased metabolism of Secobarbital caused by Sunitinib mediated induction of CYP450 enzyme. Gastrointestinal stromal tumour [2B5B] [25]
Avapritinib DMK2GZX Moderate Increased metabolism of Secobarbital caused by Avapritinib mediated induction of CYP450 enzyme. Gastrointestinal stromal tumour [2B5B] [14]
Brimonidine DMQLT4N Moderate Additive CNS depression effects by the combination of Secobarbital and Brimonidine. Glaucoma [9C61] [67]
Ergotamine DMKR3C5 Moderate Increased metabolism of Secobarbital caused by Ergotamine mediated induction of CYP450 enzyme. Headache [8A80-8A84] [25]
Carvedilol DMHTEAO Moderate Increased metabolism of Secobarbital caused by Carvedilol mediated induction of CYP450 enzyme. Heart failure [BD10-BD1Z] [68]
Digitoxin DMWVIGP Moderate Increased metabolism of Secobarbital caused by Digitoxin mediated induction of CYP450 enzyme. Heart failure [BD10-BD1Z] [69]
Boceprevir DMBSHMF Moderate Increased metabolism of Secobarbital caused by Boceprevir mediated induction of CYP450 enzyme. Hepatitis virus infection [1E50-1E51] [70]
Telaprevir DMMRV29 Moderate Increased metabolism of Secobarbital caused by Telaprevir mediated induction of CYP450 enzyme. Hepatitis virus infection [1E50-1E51] [70]
MK-1439 DM215WE Moderate Increased metabolism of Secobarbital caused by MK-1439 mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [71]
Delavirdine DM3NF5G Moderate Increased metabolism of Secobarbital caused by Delavirdine mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [72]
Fosamprenavir DM4W9B3 Moderate Increased metabolism of Secobarbital caused by Fosamprenavir mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [73]
Fostemsavir DM50ILT Minor Increased metabolism of Secobarbital caused by Fostemsavir mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [23]
Tipranavir DM8HJX6 Moderate Increased metabolism of Secobarbital caused by Tipranavir mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [73]
Efavirenz DMC0GSJ Moderate Increased metabolism of Secobarbital caused by Efavirenz mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [74]
Dolutegravir DMCZGRE Minor Increased metabolism of Secobarbital caused by Dolutegravir mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [75]
Saquinavir DMG814N Moderate Increased metabolism of Secobarbital caused by Saquinavir mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [73]
Etravirine DMGV8QU Moderate Increased metabolism of Secobarbital caused by Etravirine mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [76]
Rilpivirine DMJ0QOW Moderate Increased metabolism of Secobarbital caused by Rilpivirine mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [25]
Amprenavir DMLMXE0 Moderate Increased metabolism of Secobarbital caused by Amprenavir mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [77]
Darunavir DMN3GCH Moderate Increased metabolism of Secobarbital caused by Darunavir mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [73]
Atazanavir DMSYRBX Moderate Increased metabolism of Secobarbital caused by Atazanavir mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [73]
Maraviroc DMTL94F Moderate Increased metabolism of Secobarbital caused by Maraviroc mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [25]
Ritonavir DMU764S Moderate Increased metabolism of Secobarbital caused by Ritonavir mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [73]
Acebutolol DM0TI4U Moderate Increased metabolism of Secobarbital caused by Acebutolol mediated induction of CYP450 enzyme. Hypertension [BA00-BA04] [68]
Penbutolol DM4ES8F Moderate Increased metabolism of Secobarbital caused by Penbutolol mediated induction of CYP450 enzyme. Hypertension [BA00-BA04] [78]
Losartan DM72JXH Minor Increased metabolism of Secobarbital caused by Losartan mediated induction of CYP450 enzyme. Hypertension [BA00-BA04] [79]
Nebivolol DM7F1PA Moderate Increased metabolism of Secobarbital caused by Nebivolol mediated induction of CYP450 enzyme. Hypertension [BA00-BA04] [68]
Levamlodipine DM92S6N Moderate Increased metabolism of Secobarbital caused by Levamlodipine mediated induction of CYP450 enzyme. Hypertension [BA00-BA04] [16]
Verapamil DMA7PEW Moderate Increased metabolism of Secobarbital caused by Verapamil mediated induction of CYP450 enzyme. Hypertension [BA00-BA04] [80]
Labetalol DMK8U72 Moderate Increased metabolism of Secobarbital caused by Labetalol mediated induction of CYP450 enzyme. Hypertension [BA00-BA04] [68]
Felodipine DMOSW35 Moderate Increased metabolism of Secobarbital caused by Felodipine mediated induction of CYP450 enzyme. Hypertension [BA00-BA04] [81]
Tolvaptan DMIWFRL Moderate Increased metabolism of Secobarbital caused by Tolvaptan mediated induction of CYP450 enzyme. Hypo-osmolality/hyponatraemia [5C72] [14]
Fludrocortisone DMUDIR8 Moderate Increased metabolism of Secobarbital caused by Fludrocortisone mediated induction of CYP450 enzyme. Hypo-osmolality/hyponatraemia [5C72] [37]
Levothyroxine DMHN027 Moderate Increased metabolism of Secobarbital caused by Levothyroxine mediated induction of CYP450 enzyme. Hypo-thyroidism [5A00] [14]
Lesinurad DMUR64T Moderate Increased metabolism of Secobarbital caused by Lesinurad mediated induction of CYP450 enzyme. Inborn purine/pyrimidine/nucleotide metabolism error [5C55] [43]
Suvorexant DM0E6S3 Moderate Increased metabolism of Secobarbital caused by Suvorexant mediated induction of CYP450 enzyme. Insomnia [7A00-7A0Z] [82]
Tasimelteon DMLOQ1V Moderate Increased metabolism of Secobarbital caused by Tasimelteon mediated induction of CYP450 enzyme. Insomnia [7A00-7A0Z] [83]
ITI-007 DMUQ1DO Major Increased metabolism of Secobarbital caused by ITI-007 mediated induction of CYP450 enzyme. Insomnia [7A00-7A0Z] [84]
Naloxegol DML0B41 Moderate Increased metabolism of Secobarbital caused by Naloxegol mediated induction of CYP450 enzyme. Large intestine motility disorder [DB32] [85]
Pemigatinib DM819JF Moderate Increased metabolism of Secobarbital caused by Pemigatinib mediated induction of CYP450 enzyme. Liver cancer [2C12] [86]
Crizotinib DM4F29C Moderate Increased metabolism of Secobarbital caused by Crizotinib mediated induction of CYP450 enzyme. Lung cancer [2C25] [87]
Brigatinib DM7W94S Moderate Increased metabolism of Secobarbital caused by Brigatinib mediated induction of CYP450 enzyme. Lung cancer [2C25] [25]
Ceritinib DMB920Z Moderate Increased metabolism of Secobarbital caused by Ceritinib mediated induction of CYP450 enzyme. Lung cancer [2C25] [88]
Erlotinib DMCMBHA Moderate Increased metabolism of Secobarbital caused by Erlotinib mediated induction of CYP450 enzyme. Lung cancer [2C25] [89]
Lurbinectedin DMEFRTZ Moderate Increased metabolism of Secobarbital caused by Lurbinectedin mediated induction of CYP450 enzyme. Lung cancer [2C25] [90]
Osimertinib DMRJLAT Moderate Increased metabolism of Secobarbital caused by Osimertinib mediated induction of CYP450 enzyme. Lung cancer [2C25] [91]
Capmatinib DMYCXKL Moderate Increased metabolism of Secobarbital caused by Capmatinib mediated induction of CYP450 enzyme. Lung cancer [2C25] [92]
Selpercatinib DMZR15V Moderate Increased metabolism of Secobarbital caused by Selpercatinib mediated induction of CYP450 enzyme. Lung cancer [2C25] [23]
Artemether DM48QOT Moderate Increased metabolism of Secobarbital caused by Artemether mediated induction of CYP450 enzyme. Malaria [1F40-1F45] [25]
Quinine DMSWYF5 Moderate Increased metabolism of Secobarbital caused by Quinine mediated induction of CYP450 enzyme. Malaria [1F40-1F45] [93]
Idelalisib DM602WT Moderate Increased metabolism of Secobarbital caused by Idelalisib mediated induction of CYP450 enzyme. Mature B-cell leukaemia [2A82] [94]
GDC-0199 DMH0QKA Moderate Increased metabolism of Secobarbital caused by GDC-0199 mediated induction of CYP450 enzyme. Mature B-cell leukaemia [2A82] [95]
IPI-145 DMWA24P Moderate Increased metabolism of Secobarbital caused by IPI-145 mediated induction of CYP450 enzyme. Mature B-cell leukaemia [2A82] [96]
Acalabrutinib DM7GCVW Moderate Increased metabolism of Secobarbital caused by Acalabrutinib mediated induction of CYP450 enzyme. Mature B-cell lymphoma [2A85] [97]
Ibrutinib DMHZCPO Moderate Increased metabolism of Secobarbital caused by Ibrutinib mediated induction of CYP450 enzyme. Mature B-cell lymphoma [2A85] [98]
Vincristine DMINOX3 Moderate Increased metabolism of Secobarbital caused by Vincristine mediated induction of CYP450 enzyme. Mature B-cell lymphoma [2A85] [99]
Ponatinib DMYGJQO Moderate Increased metabolism of Secobarbital caused by Ponatinib mediated induction of CYP450 enzyme. Mature B-cell lymphoma [2A85] [25]
Vemurafenib DM62UG5 Moderate Increased metabolism of Secobarbital caused by Vemurafenib mediated induction of CYP450 enzyme. Melanoma [2C30] [100]
Selumetinib DMC7W6R Moderate Increased metabolism of Secobarbital caused by Selumetinib mediated induction of CYP450 enzyme. Melanoma [2C30] [101]
LGX818 DMNQXV8 Moderate Increased metabolism of Secobarbital caused by LGX818 mediated induction of CYP450 enzyme. Melanoma [2C30] [102]
Estrone DM5T6US Moderate Increased metabolism of Secobarbital caused by Estrone mediated induction of CYP450 enzyme. Menopausal disorder [GA30] [30]
Ethinyl estradiol DMODJ40 Moderate Increased metabolism of Secobarbital caused by Ethinyl estradiol mediated induction of CYP450 enzyme. Menopausal disorder [GA30] [30]
Allopregnanolone DMNLHAC Moderate Additive CNS depression effects by the combination of Secobarbital and Allopregnanolone. Mental/behavioural/neurodevelopmental disorder [6E20-6E8Z] [103]
Ubrogepant DM749I3 Moderate Increased metabolism of Secobarbital caused by Ubrogepant mediated induction of CYP450 enzyme. Migraine [8A80] [104]
Propranolol DM79NTF Moderate Increased metabolism of Secobarbital caused by Propranolol mediated induction of CYP450 enzyme. Migraine [8A80] [68]
Lasmiditan DMXLVDT Moderate Additive CNS depression effects by the combination of Secobarbital and Lasmiditan. Migraine [8A80] [105]
Dihydrotachysterol DMFB97P Moderate Increased metabolism of Secobarbital caused by Dihydrotachysterol mediated induction of CYP450 enzyme. Mineral deficiency [5B5K] [106]
Flibanserin DM70DTN Moderate Additive CNS depression effects by the combination of Secobarbital and Flibanserin. Mood disorder [6A60-6E23] [107]
Panobinostat DM58WKG Moderate Increased metabolism of Secobarbital caused by Panobinostat mediated induction of CYP450 enzyme. Multiple myeloma [2A83] [108]
Thalidomide DM70BU5 Moderate Additive CNS depression effects by the combination of Secobarbital and Thalidomide. Multiple myeloma [2A83] [42]
Nilotinib DM7HXWT Moderate Increased metabolism of Secobarbital caused by Nilotinib mediated induction of CYP450 enzyme. Myeloproliferative neoplasm [2A20] [109]
Ruxolitinib DM7Q98D Moderate Increased metabolism of Secobarbital caused by Ruxolitinib mediated induction of CYP450 enzyme. Myeloproliferative neoplasm [2A20] [110]
Imatinib DM7RJXL Moderate Increased metabolism of Secobarbital caused by Imatinib mediated induction of CYP450 enzyme. Myeloproliferative neoplasm [2A20] [111]
Dasatinib DMJV2EK Moderate Increased metabolism of Secobarbital caused by Dasatinib mediated induction of CYP450 enzyme. Myeloproliferative neoplasm [2A20] [25]
Modafinil DMYILBE Moderate Increased metabolism of Secobarbital caused by Modafinil mediated induction of CYP450 enzyme. Narcolepsy [7A20] [112]
Rolapitant DM8XP26 Moderate Increased metabolism of Secobarbital caused by Rolapitant mediated induction of CYP450 enzyme. Nausea/vomiting [MD90] [113]
E-2007 DMJDYNQ Moderate Increased metabolism of Secobarbital caused by E-2007 mediated induction of CYP450 enzyme. Neuropathy [8C0Z] [14]
Bupropion DM5PCS7 Moderate Increased metabolism of Secobarbital caused by Bupropion mediated induction of CYP450 enzyme. Nicotine use disorder [6C4A] [114]
Entrectinib DMMPTLH Moderate Increased metabolism of Secobarbital caused by Entrectinib mediated induction of CYP450 enzyme. Non-small cell lung cancer [2C25] [14]
Levomethadyl Acetate DM06HG5 Major Additive CNS depression effects by the combination of Secobarbital and Levomethadyl Acetate. Opioid use disorder [6C43] [39]
Apraclonidine DMO4PVE Moderate Additive CNS depression effects by the combination of Secobarbital and Apraclonidine. Optic nerve disorder [9C40] [67]
Olaparib DM8QB1D Moderate Increased metabolism of Secobarbital caused by Olaparib mediated induction of CYP450 enzyme. Ovarian cancer [2C73] [25]
Altretamine DMKLAYG Moderate Increased metabolism of Secobarbital caused by Altretamine mediated induction of CYP450 enzyme. Ovarian cancer [2C73] [115]
Pentazocine DM1XBHS Major Additive CNS depression effects by the combination of Secobarbital and Pentazocine. Pain [MG30-MG3Z] [46]
Dextropropoxyphene DM23HCX Major Additive CNS depression effects by the combination of Secobarbital and Dextropropoxyphene. Pain [MG30-MG3Z] [116]
Butorphanol DM5KYPJ Major Additive CNS depression effects by the combination of Secobarbital and Butorphanol. Pain [MG30-MG3Z] [117]
Oxymorphone DM65AGJ Major Additive CNS depression effects by the combination of Secobarbital and Oxymorphone. Pain [MG30-MG3Z] [46]
Levorphanol DMGS80V Major Additive CNS depression effects by the combination of Secobarbital and Levorphanol. Pain [MG30-MG3Z] [46]
Dezocine DMJDB0Y Major Additive CNS depression effects by the combination of Secobarbital and Dezocine. Pain [MG30-MG3Z] [39]
Nalbuphine DMOSQGU Major Additive CNS depression effects by the combination of Secobarbital and Nalbuphine. Pain [MG30-MG3Z] [46]
Buprenorphine DMPRI8G Major Additive CNS depression effects by the combination of Secobarbital and Buprenorphine. Pain [MG30-MG3Z] [118]
Hydrocodone DMQ2JO5 Major Additive CNS depression effects by the combination of Secobarbital and Hydrocodone. Pain [MG30-MG3Z] [119]
Meperidine DMX4GND Major Increased metabolism of Secobarbital caused by Meperidine mediated induction of CYP450 enzyme. Pain [MG30-MG3Z] [14]
Oxycodone DMXLKHV Major Additive CNS depression effects by the combination of Secobarbital and Oxycodone. Pain [MG30-MG3Z] [117]
Biperiden DME78OA Moderate Additive CNS depression effects by the combination of Secobarbital and Biperiden. Parkinsonism [8A00] [120]
Pimavanserin DMR7IVC Moderate Increased metabolism of Secobarbital caused by Pimavanserin mediated induction of CYP450 enzyme. Parkinsonism [8A00] [121]
Macimorelin DMQYJIR Moderate Increased metabolism of Secobarbital caused by Macimorelin mediated induction of CYP450 enzyme. Pituitary gland disorder [5A60-5A61] [122]
Lefamulin DME6G97 Moderate Increased metabolism of Secobarbital caused by Lefamulin mediated induction of CYP450 enzyme. Pneumonia [CA40] [123]
Betamethasone DMAHJEF Moderate Increased metabolism of Secobarbital caused by Betamethasone mediated induction of CYP450 enzyme. Postoperative inflammation [1A00-CA43] [37]
Hydrocortisone DMGEMB7 Moderate Increased metabolism of Secobarbital caused by Hydrocortisone mediated induction of CYP450 enzyme. Postoperative inflammation [1A00-CA43] [37]
Ergonovine DM0VEC1 Moderate Increased metabolism of Secobarbital caused by Ergonovine mediated induction of CYP450 enzyme. Postpartum haemorrhage [JA43] [25]
Lonafarnib DMGM2Z6 Moderate Increased metabolism of Secobarbital caused by Lonafarnib mediated induction of CYP450 enzyme. Premature ageing appearance [LD2B] [124]
Enzalutamide DMGL19D Moderate Increased metabolism of Secobarbital caused by Enzalutamide mediated induction of CYP450 enzyme. Prostate cancer [2C82] [125]
Darolutamide DMV7YFT Moderate Increased metabolism of Secobarbital caused by Darolutamide mediated induction of CYP450 enzyme. Prostate cancer [2C82] [126]
Apremilast DMTWS9E Moderate Increased metabolism of Secobarbital caused by Apremilast mediated induction of CYP450 enzyme. Psoriasis [EA90] [127]
Riociguat DMXBLMP Moderate Increased metabolism of Secobarbital caused by Riociguat mediated induction of CYP450 enzyme. Pulmonary hypertension [BB01] [128]
Everolimus DM8X2EH Moderate Increased metabolism of Secobarbital caused by Everolimus mediated induction of CYP450 enzyme. Renal cell carcinoma [2C90] [25]
Axitinib DMGVH6N Moderate Increased metabolism of Secobarbital caused by Axitinib mediated induction of CYP450 enzyme. Renal cell carcinoma [2C90] [129]
Temsirolimus DMS104F Moderate Increased metabolism of Secobarbital caused by Temsirolimus mediated induction of CYP450 enzyme. Renal cell carcinoma [2C90] [25]
Tofacitinib DMBS370 Moderate Increased metabolism of Secobarbital caused by Tofacitinib mediated induction of CYP450 enzyme. Rheumatoid arthritis [FA20] [25]
Fenoprofen DML5VQ0 Minor Increased metabolism of Secobarbital caused by Fenoprofen mediated induction of CYP450 enzyme. Rheumatoid arthritis [FA20] [130]
Quetiapine DM1N62C Moderate Increased metabolism of Secobarbital caused by Quetiapine mediated induction of CYP450 enzyme. Schizophrenia [6A20] [25]
Aripiprazole DM3NUMH Moderate Increased metabolism of Secobarbital caused by Aripiprazole mediated induction of CYP450 enzyme. Schizophrenia [6A20] [131]
Fentanyl DM8WAHT Major Additive CNS depression effects by the combination of Secobarbital and Fentanyl. Sensation disturbance [MB40] [117]
Sufentanil DMU7YEL Major Additive CNS depression effects by the combination of Secobarbital and Sufentanil. Sensation disturbance [MB40] [46]
Avanafil DM75CXN Moderate Increased metabolism of Secobarbital caused by Avanafil mediated induction of CYP450 enzyme. Sexual dysfunction [HA00-HA01] [132]
Tadalafil DMJZHT1 Moderate Increased metabolism of Secobarbital caused by Tadalafil mediated induction of CYP450 enzyme. Sexual dysfunction [HA00-HA01] [14]
LDE225 DMM9F25 Moderate Increased metabolism of Secobarbital caused by LDE225 mediated induction of CYP450 enzyme. Skin cancer [2C30-2C37] [133]
Larotrectinib DM26CQR Moderate Increased metabolism of Secobarbital caused by Larotrectinib mediated induction of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [25]
Methylprednisolone DM4BDON Moderate Increased metabolism of Secobarbital caused by Methylprednisolone mediated induction of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [37]
Vinblastine DM5TVS3 Moderate Increased metabolism of Secobarbital caused by Vinblastine mediated induction of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [99]
Docetaxel DMDI269 Moderate Increased metabolism of Secobarbital caused by Docetaxel mediated induction of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [134]
Trabectedin DMG3Y89 Moderate Increased metabolism of Secobarbital caused by Trabectedin mediated induction of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [14]
Armodafinil DMGB035 Moderate Increased metabolism of Secobarbital caused by Armodafinil mediated induction of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [112]
LEE011 DMMX75K Moderate Increased metabolism of Secobarbital caused by LEE011 mediated induction of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [25]
Prednisolone DMQ8FR2 Moderate Increased metabolism of Secobarbital caused by Prednisolone mediated induction of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [37]
Norethindrone DMTY169 Moderate Increased metabolism of Secobarbital caused by Norethindrone mediated induction of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [30]
Taxol DMUOT9V Moderate Increased metabolism of Secobarbital caused by Taxol mediated induction of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [135]
Doxorubicin DMVP5YE Moderate Increased metabolism of Secobarbital caused by Doxorubicin mediated induction of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [14]
Warfarin DMJYCVW Major Increased metabolism of Secobarbital caused by Warfarin mediated induction of CYP450 enzyme. Supraventricular tachyarrhythmia [BC81] [136]
Fostamatinib DM6AUHV Moderate Increased metabolism of Secobarbital caused by Fostamatinib mediated induction of CYP450 enzyme. Thrombocytopenia [3B64] [23]
Apixaban DM89JLN Moderate Increased metabolism of Secobarbital caused by Apixaban mediated induction of CYP450 enzyme. Thrombosis [DB61-GB90] [137]
Brilinta DMBR01X Moderate Increased metabolism of Secobarbital caused by Brilinta mediated induction of CYP450 enzyme. Thrombosis [DB61-GB90] [138]
Cabozantinib DMIYDT4 Moderate Increased metabolism of Secobarbital caused by Cabozantinib mediated induction of CYP450 enzyme. Thyroid cancer [2D10] [139]
Tizanidine DMR2IQ4 Moderate Additive CNS depression effects by the combination of Secobarbital and Tizanidine. Tonus and reflex abnormality [MB47] [140]
Sirolimus DMGW1ID Moderate Increased metabolism of Secobarbital caused by Sirolimus mediated induction of CYP450 enzyme. Transplant rejection [NE84] [25]
Canagliflozin DMFRM1I Moderate Increased metabolism of Secobarbital caused by Canagliflozin mediated induction of UGT. Type 2 diabetes mellitus [5A11] [25]
Saxagliptin DMGXENV Moderate Increased metabolism of Secobarbital caused by Saxagliptin mediated induction of CYP450 enzyme. Type 2 diabetes mellitus [5A11] [141]
Linagliptin DMWFJTR Moderate Increased metabolism of Secobarbital caused by Linagliptin mediated induction of CYP450 enzyme. Type 2 diabetes mellitus [5A11] [142]
Elagolix DMB2C0E Moderate Increased metabolism of Secobarbital caused by Elagolix mediated induction of CYP450 enzyme. Uterine fibroid [2E86] [143]
Triamcinolone DM98IXF Moderate Increased metabolism of Secobarbital caused by Triamcinolone mediated induction of CYP450 enzyme. Vasomotor/allergic rhinitis [CA08] [37]
Propafenone DMPIBJK Minor Increased metabolism of Secobarbital caused by Propafenone. Ventricular tachyarrhythmia [BC71] [144]
⏷ Show the Full List of 215 DDI Information of This Drug

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG
DIG Name DIG ID PubChem CID Functional Classification
Quinoline yellow WS E00309 24671 Colorant
FD&C red no. 3 E00629 Not Available Colorant
Magnesium stearate E00208 11177 lubricant
Titanium dioxide E00322 26042 Coating agent; Colorant; Opacifying agent
Pharmaceutical Formulation
Formulation Name Drug Dosage Dosage Form Route
Secobarbital 100 mg capsule 100 mg Oral Capsule Oral
Jump to Detail Pharmaceutical Formulation Page of This Drug

References

1 Secobarbital FDA Label
2 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
3 BDDCS applied to over 900 drugs
4 Estimating the safe starting dose in phase I clinical trials and no observed effect level based on QSAR modeling of the human maximum recommended daily dose
5 DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6.
6 Inhibition of activator protein 1 by barbiturates is mediated by differential effects on mitogen-activated protein kinases and the small G proteins ras and rac-1. J Pharmacol Exp Ther. 2004 Dec;311(3):1232-40. doi: 10.1124/jpet.104.071332. Epub 2004 Jul 19.
7 Identification and validation of novel human pregnane X receptor activators among prescribed drugs via ligand-based virtual screening. Drug Metab Dispos. 2011 Feb;39(2):337-44. doi: 10.1124/dmd.110.035808. Epub 2010 Nov 10.
8 Bidstrup TB, Bjornsdottir I, Sidelmann UG, Thomsen MS, Hansen KT "CYP2C8 and CYP3A4 are the principal enzymes involved in the human in vitro biotransformation of the insulin secretagogue repaglinide." Br J Clin Pharmacol 56 (2003): 305-14. [PMID: 12919179]
9 Dutreix C, Munarini F, Lorenzo S, Roesel J, Wang Y "Investigation into CYP3A4-mediated drug-drug interactions on midostaurin in healthy volunteers." Cancer Chemother Pharmacol 72 (2013): 1223-34. [PMID: 24085261]
10 Product Information. Xospata (gilteritinib). Astellas Pharma US, Inc, Deerfield, IL.
11 Liu S-J, Wang RI "Case report of barbiturate-induced enhancement of methadone metabolism and withdrawal syndrome." Am J Psychiatry 141 (1984): 1287-8. [PMID: 6486271]
12 Product Information. Lysodren (mitotane). Bristol-Myers Squibb, Princeton, NJ.
13 Product Information. Aricept (donepezil). Pfizer US Pharmaceuticals, New York, NY.
14 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
15 Product Information. Multaq (dronedarone). sanofi-aventis , Bridgewater, NJ.
16 Hamann SR, Blouin RA, Chang SL, et al "Effects of hemodynamic changes on the elimination kinetics of verapamil and nifedipine." J Pharmacol Exp Ther 231 (1984): 301-5. [PMID: 6491984]
17 Product Information. Sirturo (bedaquiline). Janssen Pharmaceuticals, Titusville, NJ.
18 Kivisto KT, Lamberg TS, Neuvonen PJ "Interactions of buspirone with itraconazole and rifampicin: Effects on the pharmacokinetics of the active 1-(2-pyrimidinyl)-piperazine metabolite of buspirone." Pharmacol Toxicol 84 (1999): 94-7. [PMID: 10068153]
19 Product Information. VFEND (voriconazole). Pfizer U.S. Pharmaceuticals, New York, NY.
20 Bukowskyj M, Nakatsu K, Munt PW "Theophylline reassessed." Ann Intern Med 101 (1984): 63-73. [PMID: 6145380]
21 Gupte S "Phenobarbital and metabolism of metronidazole." N Engl J Med 308 (1983): 529. [PMID: 6823276]
22 Ambrose PJ "Clinical pharmacokinetics of chloramphenicol and chloramphenicol succinate." Clin Pharmacokinet 9 (1984): 222-38. [PMID: 6375931]
23 Product Information. Diabinese (chlorpropamide). Pfizer US Pharmaceuticals, New York, NY.
24 Product Information. Ixempra (ixabepilone). Bristol-Myers Squibb, Princeton, NJ.
25 Cerner Multum, Inc. "Australian Product Information.".
26 Product Information. Verzenio (abemaciclib). Lilly, Eli and Company, Indianapolis, IN.
27 Product Information. Aromasin (exemestane) Pharmacia & Upjohn, Kalamazoo, MI.
28 Baciewicz AM "Oral contraceptive drug interactions." Ther Drug Monit 7 (1985): 26-35. [PMID: 2859674]
29 Product Information. Piqray (alpelisib). Novartis Pharmaceuticals, East Hanover, NJ.
30 Back DJ, Breckenridge AM, Crawford FE, MacIver M, Orne ML, Rowe PH "Interindividual variation and drug interactions with hormonal steroid contraceptives." Drugs 21 (1981): 46-61. [PMID: 7009137]
31 Biochem Pharmacol "Variable contribution of cytochromes P450 2D6, 2C9, and 3A4 to the 4-hydroxylation of tamoxifen by human liver microsomes." Biochem Pharmacol 53 (1997): 171-8. [PMID: 9037249]
32 Product Information. Jevtana (cabazitaxel). sanofi-aventis , Bridgewater, NJ.
33 Berthou F, Dreano Y, Belloc C, Kangas L, Gautier JC, Beaune P "Involvement of cytochrome P450 3A enzyme family in the major metabolic pathways of toremifene in human liver microsomes." Biochem Pharmacol 47 (1994): 1883-95. [PMID: 8204106]
34 Product Information. Bosulif (bosutinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
35 Bullman J, Nicholls A, Van Landingham K, et al. "Effects of lamotrigine and phenytoin on the pharmacokinetics of atorvastatin in healthy volunteers." Epilepsia 52 (2011): 1351-8. [PMID: 21635243]
36 Bruderer S, Aanismaa P, Homery MC, et al. "Effect of cyclosporine and rifampin on the pharmacokinetics of macitentan, a tissue-targeting dual endothelin receptor antagonist." AAPS J 14 (2012): 68-78. [PMID: 22189899]
37 Bartoszek M, Brenner AM, Szefler SJ "Prednisolone and methylprednisolone kinetics in children receiving anticonvulsant therapy." Clin Pharmacol Ther 42 (1987): 424-32. [PMID: 3665340]
38 Product Information. Daurismo (glasdegib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
39 US Food and Drug Administration "FDA warns about serious risks and death when combining opioid pain or cough medicines with benzodiazepines requires its strongest warning.".
40 Antlitz AM, Tolentino M, Kosai MF "Effect of butabarbital on orally administered anticoagulants." Curr Ther Res Clin Exp 10 (1968): 70-3. [PMID: 4967727]
41 Crews KR, Stewart CF, Jones-Wallace D, et al "Altered irinotecan pharmacokinetics in pediatric high-grade glioma patients receiving enzyme-inducing anticonvulsant therapy." Clin Cancer Res 8 (2002): 2202-9. [PMID: 12114421]
42 Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
43 Patel S, Robinson R, Burk M "Hypertensive crisis associated with St. John's Wort." Am J Med 112 (2002): 507-8. [PMID: 11959071]
44 Gill SS, Wright EM, Reilly CS "Pharmacokinetic interaction of propofol and fentanyl: single bolus injection study." Br J Anaesth 65 (1990): 760-5. [PMID: 2265045]
45 Brodeur J, Paquin P, Authier L, Geadah D, Yamauchi M, Cote MG "Influence of phenobarbital pretreatment on methoxyflurane and sodium fluoride nephropathy in Fischer 344 Rats." Toxicol Appl Pharmacol 37 (1976): 349-61. [PMID: 982456]
46 US Food and Drug Administration "FDA warns about serious risks and death when combining opioid pain or cough medicines with benzodiazepines requires its strongest warning.".
47 Product Information. Korlym (mifepristone). Corcept Therapeutics Incorporated, Menlo Park, CA.
48 Product Information. Kalydeco (ivacaftor). Vertex Pharmaceuticals, Cambridge, MA.
49 Gupta RC, Kofoed J "Toxological statistics for barbiturates, other sedatives, and tranquilizers in Ontario: a 10-year survey." Can Med Assoc J 94 (1966): 863-5. [PMID: 5929537]
50 Product Information. Xarelto (rivaroxaban). Bayer Inc, Toronto, IA.
51 Product Information. Emend (aprepitant). Merck & Company Inc, West Point, PA.
52 Ciraulo DA, Shader RI "Fluoxetine drug-drug interactions. II." J Clin Psychopharmacol 10 (1990): 213-7. [PMID: 2198298]
53 Product Information. Viibryd (vilazodone). Trovis Pharmaceuticals LLC, New Haven, CT.
54 Product Information. Paxil (paroxetine). GlaxoSmithKline, Research Triangle Park, NC.
55 Product Information. Brintellix (vortioxetine). Takeda Pharmaceuticals America, Lincolnshire, IL.
56 Nakasa H, Nakamura H, Ono S, Tsutsui M, Kiuchi M, Ohmori S, Kitada M "Prediction of drug-drug interactions of zonisamide metabolism in humans from in vitro data." Eur J Clin Pharmacol 54 (1998): 177-83. [PMID: 9626925]
57 Kuranari M, Tatsukawa H, Seike M, et al. "Effect of phenytoin on phenobarbital pharmacokinetics in a patient with epilepsy." Ann Pharmacother 29 (1995): 83-4. [PMID: 7711354]
58 Benetello P, Furlanut M "Primidone-carbamazepine interaction: clinical consequences." Int J Clin Pharmacol Res 7 (1987): 165-8. [PMID: 3583497]
59 Bittencourt PR, Gracia CM, Martins R, et al "Phenytoin and carbamazepine decrease oral bioavailability of praziquantel." Neurology 42 (1992): 492-6. [PMID: 1549207]
60 Product Information. Aliqopa (copanlisib). Bayer Pharmaceutical Inc, West Haven, CT.
61 Product Information. Tazverik (tazemetostat). Epizyme, Inc, Cambridge, MA.
62 Product Information. VESIcare (solifenacin). GlaxoSmithKline, Research Triangle Park, NC.
63 Product Information. Myrbetriq (mirabegron). Astellas Pharma US, Inc, Deerfield, IL.
64 Product Information. Enablex (darifenacin). Novartis Pharmaceuticals, East Hanover, NJ.
65 Product Information. Cancidas (caspofungin) Merck & Co, Inc, West Point, PA.
66 Somogyi A, Thielscher S, Gugler R "Influence of phenobarbital treatment on cimetidine kinetics." Eur J Clin Pharmacol 19 (1981): 343-7. [PMID: 7238562]
67 Product Information. Alphagan (brimonidine ophthalmic). Allergan Inc, Irvine, CA.
68 Branch RA, Herman RJ "Enzyme induction and beta-adrenergic receptor blocking drugs." Br J Clin Pharmacol 17 (1984): s77-84. [PMID: 6146342]
69 Cardoso MT, Carvalhas ML. Effects of phenobarbital on digitoxin metabolism in guinea-pig liver slices. Xenobiotica. 1980;10(10):779-784. [PMID: 7456493]
70 Product Information. Incivek (telaprevir). Vertex Pharmaceuticals, Cambridge, MA.
71 Product Information. Pifeltro (doravirine). Merck & Company Inc, Whitehouse Station, NJ.
72 Borin MT, Chambers JH, Carel BJ, Gagnon S, Freimuth WW "Pharmacokinetic study of the interaction between rifampin and delavirdine mesylate." Clin Pharmacol Ther 61 (1997): 544-53. [PMID: 9164416]
73 Acosta EP, Henry K, Baken L, Page LM, Fletcher CV "Indinavir concentrations and antiviral effect." Pharmacotherapy 19 (1999): 708-12. [PMID: 10391416]
74 Marzolini C, Telenti A, Decosterd LA, Greub G, Biollaz J, Buclin T "Efavirenz plasma levels can predict treatment failure and central nervous system side effects in HIV-1-infected patients." Aids 15 (2001): 71-5. [PMID: 11192870]
75 Product Information. Tivicay (dolutegravir). ViiV Healthcare, Research Triangle Park, NC.
76 Product Information. Intelence (etravirine). Ortho Biotech Inc, Bridgewater, NJ.
77 Product Information. Reyataz (atazanavir). Bristol-Myers Squibb, Princeton, NJ.
78 Haglund K, Seideman P, Colliste P, Borg KO, von Bahr C "Influence of pentobarbital on metoprolol plasma levels." Clin Pharmacol Ther 26 (1979): 326-9. [PMID: 466926]
79 Goldberg MR, Lo MW, Deutsch PJ, Wilson SE, Mcwilliams EJ, Mccrea JB "Phenobarbital minimally alters plasma concentrations of losartan and its active metabolite e-3174." Clin Pharmacol Ther 59 (1996): 268-74. [PMID: 8653989]
80 Rutledge DR, Pieper JA, Mirvis DM "Effects of chronic phenobarbital on verapamil dispostion in humans." J Pharmacol Exp Ther 246 (1988): 7-13. [PMID: 3392664]
81 Bahls FH, Ozuna J, Ritchie DE "Interactions between calcium channel blockers and the anticonvulsants carbamazepine and phenytoin." Neurology 41 (1991): 740-2. [PMID: 2027492]
82 Product Information. Belsomra (suvorexant). Merck & Company Inc, Whitehouse Station, NJ.
83 Product Information. Hetlioz (tasimelteon). Vanda Pharmaceuticals Inc, Rockville, MD.
84 Product Information. Caplyta (lumateperone). Intra-Cellular Therapies, Inc., New York, NY.
85 Product Information. Movantik (naloxegol). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
86 Product Information. Pemazyre (pemigatinib). Incyte Corporation, Wilmington, DE.
87 Cerner Multum, Inc. "Canadian Product Information.".
88 Product Information. Zykadia (ceritinib). Novartis Pharmaceuticals, East Hanover, NJ.
89 Li J, Zhao M, He P, Hidalgo M, Baker SD "Differential metabolism of gefitinib and erlotinib by human cytochrome p450 enzymes." Clin Cancer Res 13 (2007): 3731-7. [PMID: 17575239]
90 Product Information. Zepzelca (lurbinectedin). Jazz Pharmaceuticals, Palo Alto, CA.
91 Product Information. Tagrisso (osimertinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
92 Product Information. Tabrecta (capmatinib). Novartis Pharmaceuticals, East Hanover, NJ.
93 Fabre C, Criddle J, Nolder D, Klein JL "Recrudescence of imported falciparum malaria after quinine therapy: potential drug interaction with phenytoin." Trans R Soc Trop Med Hyg 99 (2005): 871-3. [PMID: 16099004]
94 Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
95 Product Information. Venclexta (venetoclax). AbbVie US LLC, North Chicago, IL.
96 Product Information. Copiktra (duvelisib). Verastem, Inc., Needham, MA.
97 Product Information. Calquence (acalabrutinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
98 Product Information. Imbruvica (ibrutinib). Pharmacyclics Inc, Sunnyvale, CA.
99 Product Information. Marqibo (vinCRIStine liposome). Talon Therapeutics Inc, South San Francisco,, CA.
100 Product Information. Zelboraf (vemurafenib). Genentech, South San Francisco, CA.
101 Product Information. Koselugo (selumetinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
102 Product Information. Braftovi (encorafenib). Array BioPharma Inc., Boulder, CO.
103 Product Information. Zulresso (brexanolone). Sage Therapeutics, Inc., Cambridge, MA.
104 Product Information. Ubrelvy (ubrogepant). Allergan Inc, Irvine, CA.
105 Product Information. Reyvow (lasmiditan). Lilly, Eli and Company, Indianapolis, IN.
106 Product Information. Hectorol (doxercalciferol). Genzyme Corporation, Cambridge, MA.
107 Product Information. Addyi (flibanserin). Sprout Pharmaceuticals, Raleigh, NC.
108 Product Information. Farydak (panobinostat). Novartis Pharmaceuticals, East Hanover, NJ.
109 Product Information. Tasigna (nilotinib). Novartis Pharmaceuticals, East Hanover, NJ.
110 Product Information. Jakafi (ruxolitinib). Incyte Corporation, Wilmington, DE.
111 Bolton AE, Peng B, Hubert M, et al. "Effect of rifampicin on the pharmacokinetics of imatinib mesylate (Gleevec, STI571) in healthy subjects." Cancer Chemother Pharmacol 53 (2004): 102-6. [PMID: 14605865]
112 Product Information. Nuvigil (armodafinil). Cephalon Inc, West Chester, PA.
113 Product Information. Varubi (rolapitant). Tesaro Inc., Waltham, MA.
114 James WA, Lippmann S "Bupropion: overview and prescribing guidelines in depression." South Med J 84 (1991): 222-4. [PMID: 1899294]
115 Paolini A, D'Incalci M "Effect of phenobarbital pretreatment on the metabolism and antitumor activity of hexamethylmelamine." Cancer Treat Rep 70 (1986): 513-6. [PMID: 3084083]
116 Hansen BS, Dam M, Brandt J, et al "Influence of dextropropoxyphene on steady state serum levels and protein binding of three anti-epileptic drugs in man." Acta Neurol Scand 61 (1980): 357-67. [PMID: 6998251]
117 Product Information. Apadaz (acetaminophen-benzhydrocodone). KemPharm, Inc, Coralville, IA.
118 Sekar M, Mimpriss TJ "Buprenorphine, benzodiazepines and prolonged respiratory depression." Anaesthesia 42 (1987): 567-8. [PMID: 3592200]
119 Bell J, Seres V, Bowron P, Lewis J, Batey R "The use of serum methadone levels in patients receiving methadone maintenance." Clin Pharmacol Ther 43 (1988): 623-9. [PMID: 3378383]
120 Product Information. Artane (trihexyphenidyl). Lederle Laboratories, Wayne, NJ.
121 Product Information. Nuplazid (pimavanserin). Accelis Pharma, East Windsor, NJ.
122 Product Information. Macrilen (macimorelin). Aeterna Zentaris, Charleston, SC.
123 Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
124 Product Information. Zokinvy (lonafarnib). Eiger BioPharmaceuticals, Palo Alto, CA.
125 Product Information. Xtandi (enzalutamide). Astellas Pharma US, Inc, Deerfield, IL.
126 Product Information. Nubeqa (darolutamide). Bayer HealthCare Pharmaceuticals Inc., Whippany, NJ.
127 Product Information. Otezla (apremilast). Celgene Corporation, Summit, NJ.
128 Product Information. Adempas (riociguat). Bayer Pharmaceutical Inc, West Haven, CT.
129 Pithavala YK, Tortorici M, Toh M, et al "Effect of rifampin on the pharmacokinetics of axitinib (AG-013736) in Japanese and Caucasian healthy volunteers." Cancer Chemother Pharmacol 65 (2010): 563-70. [PMID: 19603168]
130 Helleberg L, Rubin A, Wolen RL, et al "A pharmacokinetic interaction in man between phenobarbitone and fenoprofen, a new anti-inflammatory agent." Br J Clin Pharmacol 1 (1974): 371-4. [PMID: 22454912]
131 Product Information. Abilify (aripiprazole). Bristol-Myers Squibb, Princeton, NJ.
132 Product Information. Stendra (avanafil). Vivus Inc, Mountain View, CA.
133 Product Information. Odomzo (sonidegib). Novartis Pharmaceuticals, East Hanover, NJ.
134 Aronson JK, Grahame-Smith DG "Clinical pharmacology: adverse drug interactions." Br Med J 282 (1981): 288-91. [PMID: 6779990]
135 Jamis-Dow CA, Klecker RW, Katki AG, Collins JM "Metabolism of Taxol by human liver microsomes and effect of inhibitors (Meeting abstract)." Proc Annu Meet Am Assoc Cancer Res 34 (1993): a21981993.
136 Aggeler PM, O'Reilly RA "Effect of heptabarbital on the response to bishydroxycoumarin in man." J Lab Clin Med 74 (1969): 229-38. [PMID: 4184022]
137 Product Information. Eliquis (apixaban). Bristol-Myers Squibb Canada Inc, Montreal, IN.
138 Canadian Pharmacists Association.
139 Product Information. Cabometyx (cabozantinib). Exelixis Inc, S San Francisco, CA.
140 Product Information. Zanaflex (tizanidine). Acorda Therapeutics, Hawthorne, NY.
141 Product Information. Onglyza (saxagliptin). Bristol-Myers Squibb, Princeton, NJ.
142 Product Information. Tradjenta (linagliptin). Boehringer Ingelheim, Ridgefield, CT.
143 Product Information. Orilissa (elagolix). AbbVie US LLC, North Chicago, IL.
144 Sams RA, Muir WW. Effects of phenobarbital on thiopental pharmacokinetics in greyhounds. Am J Vet Res. 1988;49(2):245-249. [PMID: 3348533]