Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMVONE6)

Drug Name

Epidermal growth factor Drug Info

Synonyms

62229-50-9; Urogastrone; Uroenterone; Uroanthelone; Urogastron; Kutrol; beta-Urogastrone; Anthelone U; Urogastrone [JAN]; Gastrone, gamma-uro-; Gastrone, beta-uro- (human); Epidermal growth factor (egf); CCRIS 7234; EINECS 263-468-7; EPIDERMAL GROWTH FACTOR-UROGASTRONE; Gastrone, uro- (9CI); 9010-53-1; Gentel (TN); EGF

Indication

Disease Entry	ICD 11	Status	REF
Vulnerary	ND56.Z	Approved	[1]
Wound healing	EL8Y	Phase 2	[2]

Cross-matching ID

PubChem CID: 56841751
CAS Number: CAS 62229-50-9
TTD Drug ID: DMVONE6
INTEDE Drug ID: DR1921

Molecule-Related Drug Atlas

Molecule Type:

DTT

DME

Drug Status:

Investigative Drug(s)

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Epidermal growth factor (EGF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hebervis	DMZ4A0R	Oral mucositis	DA01.11	Investigative	[6]
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Drug(s) Targeting Epidermal growth factor receptor (EGFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[7]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[8]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[9]
Erlotinib	DMCMBHA	Adrenal gland neoplasm		Approved	[10]
Vandetanib	DMRICNP	Solid tumour/cancer	2A00-2F9Z	Approved	[11]
Dacomitinib	DMOH8VY	Non-small-cell lung cancer	2C25.Y	Approved	[4]
BIBW 2992	DMTKD7Q	Non-small-cell lung cancer	2C25.Y	Approved	[12]
SKI-758	DMQ8E9R	Ischemia	8B10-8B11	Approved	[13]
Merimepodib	DM0HS92	Breast cancer	2C60-2C65	Approved	[14]
Nitroglycerin	DMQ2491	Angina pectoris	BA40	Approved	[15]
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Drug(s) Metabolized By Carboxypeptidase M (CPM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BRADYKININ	DM4R6UV	N. A.	N. A.	Phase 1	[16]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Epidermal growth factor (EGF)	TTED8JB	EGF_HUMAN	Modulator	[3]
Epidermal growth factor receptor (EGFR)	TTGKNB4	EGFR_HUMAN	Modulator	[4]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Carboxypeptidase M (CPM)^{Main DME}	DE1TNRG	CBPM_HUMAN	Substrate	[5]

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References

1	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4916).
3	Repurposing of the epidermal growth factor. Journal of Commercial Biotechnology (2011) 17, 45-52.
4	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1797).
5	Extracellular conversion of epidermal growth factor (EGF) to des-Arg53-EGF by carboxypeptidase M. J Biol Chem. 1995 Jul 21;270(29):17154-8.
6	Leadership in BioBusiness. Dr Gurinder S Shahi. Page(36).
7	Nasopharyngeal carcinoma: Current treatment options and future directions. J Nasopharyng Carcinoma, 2014, 1(16): e16.
8	Triple negative breast cancer--current status and prospective targeted treatment based on HER1 (EGFR), TOP2A and C-MYC gene assessment. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2009 Mar;153(1):13-7.
9	Gefitinib ('Iressa', ZD1839) and new epidermal growth factor receptor inhibitors. Br J Cancer. 2004 Feb 9;90(3):566-72.
10	Quantitative prediction of fold resistance for inhibitors of EGFR. Biochemistry. 2009 Sep 8;48(35):8435-48.
11	A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22.
12	Boehringer Ingelheim. Product Development Pipeline. June 2 2009.
13	Synthesis and Src kinase inhibitory activity of a series of 4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-furyl-3-quinolinecarbonitriles. J Med Chem. 2006 Dec 28;49(26):7868-76.
14	Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).
15	Emerging drugs for diabetic foot ulcers. Expert Opin Emerg Drugs. 2006 Nov;11(4):709-24.
16	Interactions between carboxypeptidase M and kinin B1 receptor in endothelial cells. Inflamm Res. 2019 Oct;68(10):845-855.