General Information of Drug (ID: DMQ2491)

Drug Name
Nitroglycerin
Synonyms
nitroglycerin; Glyceryl trinitrate; Trinitroglycerin; Nitroglycerol; Nitrostat; Nitroglycerine; Nitro-dur; Minitran; Trinitroglycerol; 55-63-0; Nitroderm; Nitroglyn; Nitrospan; Nitronet; Tridil; Glycerol trinitrate; Transderm-nitro; Transderm Nitro; Epinitril; Susadrin; Perlinganit; Nitrolingual; Nitrolan; Sustonit; Nitrocine; Trinitrin; Natispray; Lenitral; Nitrong; Niong; Nitro-Bid; Nitroderm TTS; Trinitrosan; Rectogesic; Nitroglicerina; Cordipatch; Perglottal; Nitrorectal; Gilustenon; Nitroretard; Nitroplast; Corditrine; Trinitrolong; Adesitrin; Aldonitrin; Angibid; Angiolingual; Angiplex; Anglix; Angonist; Angorin; Anogesic; Buccal; Buccard; Cardabid; Cardamist; Cardinit; Cardiodisco; Cellegesic; Chitamite; Colenitral; Dauxona; Deponit; Diafusor; Discotrine; Dynamite; GTN; Glonoin; Glycerintrinitrate; Glyceroltrinitraat; Glyceryl; Glycerylnitrat; Glytrin; Herwicard; Herzer; Klavikordal; Lentonitrina; Millisrol; Minitram; Minitro; Mionitrat; Myocon; Myoglycerin; Myovin; NTG; Niglin; Niglycon; Nirmin; Nitora; Nitradisc; Nitrangin; Nitrek; Nitriderm; NitroBid; NitroCor; NitroDur; NitroMist; NitroQuick; NitroQuik; Nitroard; Nitrobaat; Nitrobukal; Nitrocap; Nitrocard; Nitrocerin; Nitroclyn; Nitrocontin; Nitrocot; Nitrodisc; Nitrodyl; Nitrogard; Nitrogliceryna; Nitroglin; Nitroject; Nitroletten; Nitrolin; Nitrolowe; Nitromel; Nitromex; Nitromint; Nitropatch; Nitropen; Nitropercuten; Nitroperlinit; Nitroprol; Nitropront; Nitroprontan; Nitrorex; Nitrostabilin; Nitrovis; Nysconitrine; Percutol; Perganit; Plastranit; Polnitrin; Ratiopharm; Soup; Suscard; Sustac; Sustak; TNG; Temponitrin; Trinalgon; Trinipatch; Triniplas; Trinitrol; Trinitron; Turicard; Vascana; Vasoglyn; Vasolator; Vernies; Willong; Blasting gelatin; Blasting oil; Gepan Nitroglicerin; Gilucor nitro; Glycerin trinitrate; Glycerine trinitrate; Glyceryl nitrate; NITRO IV; Neos nitro OPT; Niong Retard; Nitradisc Pad; Nitradisc TTS; Nitriderm TTS; Nitro Bid; Nitro Dur; Nitro Dur TTS; Nitro Mack Retard; Nitro Retard; Nitro Rorer; Nitrobid Oint; Nitrocontin Continus; Nitroderm TTS Ext; Nitrodyl TTS; Nitrol Ointment; Nitrolingual Spray; Nitromack Retard; Nitromint Aerosol; Nitromint Retard; Nitronal Aqueous; Nitrong Retard; Nitrong parenteral; Nitrozell retard; Percutol Oint; Spirit of glonoin; Tridil sublin; Trinitrin Tablets; Trinitrina Erba; Deponit 5; Deponit TTS 10; Deponit TTS 5; Nitrocine 5; Aquo-Trimitrosan; Coro-Nitro; Deponit-5; GTN-Pohl; IMX-150; MED-2002; MQX-503; Mi-Trates; Minitran (TN); NK-843; Natispray (TN); Nit-Ret; Nitrine-TDC; Nitro-Dur 10; Nitro-Dur 5; Nitro-Gesanit Retard; Nitro-Mack Retard; Nitro-Par; Nitro-Pflaster; Nitro-Span; Nitro-Time; Nitro-lent; NitrocapTD; Nitroderm TTS-5; Nitrogard-SR; Nitroglycerin (NG); Nitroglycerin-ACC; Nitrolingual Pump Spray (TN); Nitromist (TN); Nitrong-SR; Nitrospan (TN); Nitrostat (TN); SDM No 17; SK-106N; SK-866; SK-878; Top-Nitro; Transderm Nitro (TN); Transderm-N TTS; Transderm-Nitro TTS; Transiderm-nitro; Tridil (TN); Trinipatch (TN); Trinitrate, Glyceryl; Nitro-Dur (TN); Nitro-M-Bid; Nitro-bid (TN); Nitro-dur (TN); Transderm-nitro (TN); DWP-401
Indication
Disease Entry ICD 11 Status REF
Angina pectoris BA40 Approved [1]
Diabetic foot ulcer BD54 Approved [2]
Therapeutic Class
Vasodilator Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 227.09
Logarithm of the Partition Coefficient (xlogp) 1.6
Rotatable Bond Count (rotbonds) 5
Hydrogen Bond Donor Count (hbonddonor) 0
Hydrogen Bond Acceptor Count (hbondacc) 9
ADMET Property
BDDCS Class
Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 1: high solubility and high permeability [3]
Clearance
The drug present in the plasma can be removed from the body at the rate of 194.3 mL/min/kg [4]
Elimination
0.5% of drug is excreted from urine in the unchanged form [3]
Half-life
The concentration or amount of drug in body reduced by one-half in 4.5 hours [4]
MRTD
The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 1.6356 micromolar/kg/day [5]
Unbound Fraction
The unbound fraction of drug in plasma is 0.4% [4]
Water Solubility
The ability of drug to dissolve in water is measured as 0.8 mg/mL [3]
Chemical Identifiers
Formula
C3H5N3O9
IUPAC Name
1,3-dinitrooxypropan-2-yl nitrate
Canonical SMILES
C(C(CO[N+](=O)[O-])O[N+](=O)[O-])O[N+](=O)[O-]
InChI
InChI=1S/C3H5N3O9/c7-4(8)13-1-3(15-6(11)12)2-14-5(9)10/h3H,1-2H2
InChIKey
SNIOPGDIGTZGOP-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
4510
ChEBI ID
CHEBI:28787
CAS Number
55-63-0
DrugBank ID
DB00727
TTD ID
D07YDE
ACDINA ID
D00476
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Epidermal growth factor receptor (EGFR) TTGKNB4 EGFR_HUMAN Activator [2]
Soluble guanylate cyclase (GCS) TT23PYC GCYA1_HUMAN ; GCYB1_HUMAN Modulator [6]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Angina pectoris
ICD Disease Classification BA40
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Epidermal growth factor receptor (EGFR) DTT EGFR 5.84E-05 0.32 0.55
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Nitroglycerin (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Scopolamine DMOM8AL Minor Decreased dissolution of Nitroglycerin taken sublingually caused by Scopolamine. Addictive disorder [6C50-6C5Z] [7]
Cariprazine DMJYDVK Moderate Additive hypotensive effects by the combination of Nitroglycerin and Cariprazine. Bipolar disorder [6A60] [8]
Selegiline DM6034S Moderate Additive hypotensive effects by the combination of Nitroglycerin and Selegiline. Depression [6A70-6A7Z] [9]
Isocarboxazid DMAF1NB Moderate Additive hypotensive effects by the combination of Nitroglycerin and Isocarboxazid. Depression [6A70-6A7Z] [9]
Tranylcypromine DMGB5RE Moderate Additive hypotensive effects by the combination of Nitroglycerin and Tranylcypromine. Depression [6A70-6A7Z] [9]
OPC-34712 DMHG57U Moderate Additive hypotensive effects by the combination of Nitroglycerin and OPC-34712. Depression [6A70-6A7Z] [8]
Phenelzine DMHIDUE Moderate Additive hypotensive effects by the combination of Nitroglycerin and Phenelzine. Depression [6A70-6A7Z] [9]
Mepenzolate DM8YU2F Minor Decreased dissolution of Nitroglycerin taken sublingually caused by Mepenzolate. Digestive system disease [DE2Z] [7]
Oxybutynine DMJPBAX Minor Decreased dissolution of Nitroglycerin taken sublingually caused by Oxybutynine. Discovery agent [N.A.] [7]
Meclizine DMS7T13 Minor Decreased dissolution of Nitroglycerin taken sublingually caused by Meclizine. Dizziness and giddiness [MB48] [7]
Solifenacin DMG592Q Minor Decreased dissolution of Nitroglycerin taken sublingually caused by Solifenacin. Functional bladder disorder [GC50] [7]
Tolterodine DMSHPW8 Minor Decreased dissolution of Nitroglycerin taken sublingually caused by Tolterodine. Functional bladder disorder [GC50] [7]
Propantheline DM2EN6G Minor Decreased dissolution of Nitroglycerin taken sublingually caused by Propantheline. Gastric ulcer [DA60] [7]
Procarbazine DMIK367 Moderate Additive hypotensive effects by the combination of Nitroglycerin and Procarbazine. Hodgkin lymphoma [2B30] [9]
Captopril DM458UM Moderate Additive hypotensive effects by the combination of Nitroglycerin and Captopril. Hypertension [BA00-BA04] [10]
Perindopril DMOPZDT Moderate Additive hypotensive effects by the combination of Nitroglycerin and Perindopril. Hypertension [BA00-BA04] [10]
Quinapril DMR8H31 Moderate Additive hypotensive effects by the combination of Nitroglycerin and Quinapril. Hypertension [BA00-BA04] [10]
Belladonna DM2RBWK Minor Decreased dissolution of Nitroglycerin taken sublingually caused by Belladonna. Infectious gastroenteritis/colitis [1A40] [7]
Propiomazine DMKY8V1 Moderate Additive hypotensive effects by the combination of Nitroglycerin and Propiomazine. Insomnia [7A00-7A0Z] [8]
ITI-007 DMUQ1DO Moderate Additive hypotensive effects by the combination of Nitroglycerin and ITI-007. Insomnia [7A00-7A0Z] [8]
Clidinium DMUMQZ0 Minor Decreased dissolution of Nitroglycerin taken sublingually caused by Clidinium. Irritable bowel syndrome [DD91] [7]
Dicyclomine DMZSDGX Minor Decreased dissolution of Nitroglycerin taken sublingually caused by Dicyclomine. Irritable bowel syndrome [DD91] [7]
Ozanimod DMT6AM2 Moderate Additive hypotensive effects by the combination of Nitroglycerin and Ozanimod. Multiple sclerosis [8A40] [9]
Dimenhydrinate DM264B3 Minor Decreased dissolution of Nitroglycerin taken sublingually caused by Dimenhydrinate. Nausea/vomiting [MD90] [7]
Promethazine DM6I5GR Moderate Additive hypotensive effects by the combination of Nitroglycerin and Promethazine. Nausea/vomiting [MD90] [8]
Cyclizine DM9G7BS Minor Decreased dissolution of Nitroglycerin taken sublingually caused by Cyclizine. Nausea/vomiting [MD90] [7]
Prilocaine DMI7DZ2 Major Increased risk of methemoglobinemia by the combination of Nitroglycerin and Prilocaine. Pain [MG30-MG3Z] [11]
Flavoxate DMKV4NL Minor Decreased dissolution of Nitroglycerin taken sublingually caused by Flavoxate. Pain [MG30-MG3Z] [7]
Safinamide DM0YWJC Moderate Additive hypotensive effects by the combination of Nitroglycerin and Safinamide. Parkinsonism [8A00] [9]
Rasagiline DM3WKQ4 Moderate Additive hypotensive effects by the combination of Nitroglycerin and Rasagiline. Parkinsonism [8A00] [9]
Biperiden DME78OA Minor Decreased dissolution of Nitroglycerin taken sublingually caused by Biperiden. Parkinsonism [8A00] [7]
Methylscopolamine DM5VWOB Minor Decreased dissolution of Nitroglycerin taken sublingually caused by Methylscopolamine. Peptic ulcer [DA61] [7]
Levomepromazine DMIKFEL Moderate Additive hypotensive effects by the combination of Nitroglycerin and Levomepromazine. Psychotic disorder [6A20-6A25] [8]
Quetiapine DM1N62C Moderate Additive hypotensive effects by the combination of Nitroglycerin and Quetiapine. Schizophrenia [6A20] [8]
Mesoridazine DM2ZGAN Moderate Additive hypotensive effects by the combination of Nitroglycerin and Mesoridazine. Schizophrenia [6A20] [8]
Aripiprazole DM3NUMH Moderate Additive hypotensive effects by the combination of Nitroglycerin and Aripiprazole. Schizophrenia [6A20] [8]
Iloperidone DM6AUFY Moderate Additive hypotensive effects by the combination of Nitroglycerin and Iloperidone. Schizophrenia [6A20] [8]
Paliperidone DM7NPJS Moderate Additive hypotensive effects by the combination of Nitroglycerin and Paliperidone. Schizophrenia [6A20] [8]
Perphenazine DMA4MRX Moderate Additive hypotensive effects by the combination of Nitroglycerin and Perphenazine. Schizophrenia [6A20] [8]
Molindone DMAH70G Moderate Additive hypotensive effects by the combination of Nitroglycerin and Molindone. Schizophrenia [6A20] [8]
Thiothixene DMDINC4 Moderate Additive hypotensive effects by the combination of Nitroglycerin and Thiothixene. Schizophrenia [6A20] [8]
Trifluoperazine DMKBYWI Moderate Additive hypotensive effects by the combination of Nitroglycerin and Trifluoperazine. Schizophrenia [6A20] [8]
Risperidone DMN6DXL Moderate Additive hypotensive effects by the combination of Nitroglycerin and Risperidone. Schizophrenia [6A20] [8]
Amisulpride DMSJVAM Moderate Additive hypotensive effects by the combination of Nitroglycerin and Amisulpride. Schizophrenia [6A20] [8]
Asenapine DMSQZE2 Moderate Additive hypotensive effects by the combination of Nitroglycerin and Asenapine. Schizophrenia [6A20] [8]
Methdilazine DMAUHQX Moderate Additive hypotensive effects by the combination of Nitroglycerin and Methdilazine. Vasomotor/allergic rhinitis [CA08] [8]
Trimeprazine DMEMV9D Moderate Additive hypotensive effects by the combination of Nitroglycerin and Trimeprazine. Vasomotor/allergic rhinitis [CA08] [12]
⏷ Show the Full List of 47 DDI Information of This Drug

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG
DIG Name DIG ID PubChem CID Functional Classification
Acetylated sucrose distearate E00592 71587451 Emollient
Allura red AC dye E00338 33258 Colorant
D&C red no. 22 E00206 11048 Colorant
D&C red no. 28 E00491 6097185 Colorant
D&C red no. 33 E00261 19116 Colorant
FD&C blue no. 1 E00263 19700 Colorant
FD&C blue no. 2 E00446 2723854 Colorant
Glyceryl monostearate E00310 24699 Emollient; Emulsifying agent; Emulsion stabilizing agent; Solubilizing agent; Surfactant; Viscosity-controlling agent
Quinoline yellow WS E00309 24671 Colorant
Sunset yellow FCF E00255 17730 Colorant
Beta-D-lactose E00099 6134 Diluent; Dry powder inhaler carrier; Lyophilization aid
Calcium stearate E00244 15324 lubricant
Carmellose sodium E00625 Not Available Disintegrant
FD&C red no. 3 E00629 Not Available Colorant
Ferrosoferric oxide E00231 14789 Colorant
Lactose monohydrate E00393 104938 Binding agent; Diluent; Dry powder inhaler carrier; Lyophilization aid
Magnesium stearate E00208 11177 lubricant
Polyethylene glycol 3350 E00652 Not Available Coating agent; Diluent; Ointment base; Plasticizing agent; Solvent; Suppository base; lubricant
Propylene glycol E00040 1030 Antimicrobial preservative; Humectant; Plasticizing agent; Solvent
Saccharose E00091 5988 Binding agent; Coating agent; Cryoprotectant; Diluent; Flavoring agent; Suspending agent; Viscosity-controlling agent
Silicon dioxide E00670 Not Available Anticaking agent; Opacifying agent; Viscosity-controlling agent
Talc E00520 16211421 Anticaking agent; Diluent; Glidant; lubricant
Titanium dioxide E00322 26042 Coating agent; Colorant; Opacifying agent
⏷ Show the Full List of 23 Pharmaceutical Excipients of This Drug
Pharmaceutical Formulation
Formulation Name Drug Dosage Dosage Form Route
Nitroglycerin 9 mg capsule 9 mg Extended Release Oral Capsule Oral
Nitroglycerin 2.5 mg capsule 2.5 mg Extended Release Oral Capsule Oral
Nitroglycerin 6.5 mg capsule 6.5 mg Extended Release Oral Capsule Oral
Nitroglycerin 0.3 mg tablet 0.3 mg Sublingual Tablet Oral
Nitroglycerin 0.4 mg tablet 0.4 mg Sublingual Tablet Oral
Nitroglycerin 300 mcg tablet 300 mcg Sublingual Tablet Oral
Nitroglycerin 400 mcg tablet 400 mcg Sublingual Tablet Oral
Nitroglycerin 600 mcg tablet 600 mcg Sublingual Tablet Oral
Nitroglycerin 0.6 mg tablet 0.6 mg Sublingual Tablet Oral
Jump to Detail Pharmaceutical Formulation Page of This Drug

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7053).
2 Emerging drugs for diabetic foot ulcers. Expert Opin Emerg Drugs. 2006 Nov;11(4):709-24.
3 BDDCS applied to over 900 drugs
4 Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds
5 Estimating the safe starting dose in phase I clinical trials and no observed effect level based on QSAR modeling of the human maximum recommended daily dose
6 Activators of soluble guanylate cyclase for the treatment of male erectile dysfunction. Int J Impot Res. 2002 Feb;14(1):8-14.
7 Product Information. Nitrostat (nitroglycerin). Parke-Davis, Morris Plains, NJ.
8 Aronowitz JS, Chakos MH, Safferman AZ, Lieberman JA "Syncope associated with the combination of clozapine and enalapril." J Clin Psychopharmacol 14 (1994): 429-30. [PMID: 7884028]
9 Ban TA "Drug interactions with psychoactive drugs." Dis Nerv Syst 36 (1975): 164-6. [PMID: 1116424]
10 Katz RJ, Levy WS, Buff L, Wasserman AG "Prevention of nitrate tolerance with angiotension converting enzyme inhibitors." Circulation 83 (1991): 1271-7. [PMID: 1901528]
11 Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA.".
12 Product Information. Clozaril (clozapine). Novartis Pharmaceuticals, East Hanover, NJ.