Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMWBZJD)

• Drug Name: GDC-0068 Drug Info
• Synonyms: RG7440

Indication

Disease Entry	ICD 11	Status	REF
Breast cancer	2C60-2C65	Phase 3	[1]
Colorectal cancer	2B91.Z	Phase 3	[1]
Prostate cancer	2C82.0	Phase 3	[2]
Gastric adenocarcinoma	2B72	Phase 2	[3]
Solid tumour/cancer	2A00-2F9Z	Phase 2	[4]

• Cross-matching ID:
  PubChem CID: 24788740
  ChEBI ID: CHEBI:95089
  CAS Number: CAS 1001264-89-6
  TTD Drug ID: DMWBZJD

Molecule-Related Drug Atlas

Drug(s) Targeting RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[1]
Enzastaurin	DM5H0R9	Diffuse large B-cell lymphoma	2A81	Phase 3	[1]
CI-1033	DMSI8N3	Lymphoma	2A80-2A86	Phase 2	[6]
CMX-2043	DMPSCVY	Cardiac disease	BA00-BE2Z	Phase 2	[7]
ARQ 092	DM5WK0J	Proteus syndrome	LD2C	Phase 2	[3]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[8]
RX-0201	DMTBAV3	Pancreatic cancer	2C10	Phase 2	[9]
PTX-200	DM0ZIT2	Breast cancer	2C60-2C65	Phase 2	[1]
Triciribine prodrug	DMBN1XS	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[8]
M2698	DM3PVBJ	Solid tumour/cancer	2A00-2F9Z	Phase 1	[1]
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[10]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[11]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[12]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[13]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[14]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[15]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[16]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[18]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[19]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[20]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[21]
Fructose	DM43AN2	Vomiting	MD90	Approved	[22]
Ketoprofen	DMRKXPT	Bursitis		Approved	[22]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[23]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[24]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[25]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[26]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[27]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[28]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[29]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[30]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[31]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[32]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[33]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[35]
Fructose	DM43AN2	Vomiting	MD90	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[37]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
RAC-alpha serine/threonine-protein kinase (AKT1)	TTWTSCV	AKT1_HUMAN	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
RAC-alpha serine/threonine-protein kinase (AKT1)	OT8H2YY7	AKT1_HUMAN	Post-Translational Modifications	[5]
Tumor necrosis factor (TNF)	OT4IE164	TNFA_HUMAN	Protein Interaction/Cellular Processes	[5]
Tumor necrosis factor receptor superfamily member 6 (FAS)	OTP9XG86	TNR6_HUMAN	Protein Interaction/Cellular Processes	[5]

References

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• [2] Clinical pipeline report, company report or official report of Roche.
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