Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMWHDRI)

• Drug Name: 4-(2-Aminoethyl) benzenesulfonyl fluoride Drug Info
• Synonyms: 4-(2-Aminoethyl)benzenesulfonyl fluoride; 4-(2-Aminoethyl)benzenesulfonylfluoride; 4-(2-aminoethyl)-benzenesulfonyl fluoride; 4-(2-aminoethyl)benzene-1-sulfonyl fluoride; 4-beta-Aminoethylbenzolsulfofluoride; AC1L1C1L; AC1Q4OX1; AEBSF; AEBSF.HCl; AES; Benzenesulfonyl fluoride, 4-(2-aminoethyl)-; C8H10FNO2S; CHEMBL1256178; Lopac-A-8456; Lopac0_000132; MGSKVZWGBWPBTF-UHFFFAOYSA-N; Pefabloc; SR-01000075690
• Cross-matching ID:
  PubChem CID: 1701
  CAS Number: CAS 34284-75-8
  TTD Drug ID: DMWHDRI
  VARIDT Drug ID: DR01300

Molecule-Related Drug Atlas

Drug(s) Transported By Multidrug resistance-associated protein 4 (ABCC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[2]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[3]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[4]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[5]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[6]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[7]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[8]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[9]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[10]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[6]

Molecular Interaction Atlas of This Drug

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Multidrug resistance-associated protein 4 (ABCC4)	DTCSGPB	MRP4_HUMAN	Substrate	[1]

References

• [1] Fluo-cAMP is transported by multidrug resistance-associated protein isoform 4 in rat choroid plexus. J Neurochem. 2010 Oct;115(1):200-8.
• [2] Interaction of nonsteroidal anti-inflammatory drugs with multidrug resistance protein (MRP) 2/ABCC2- and MRP4/ABCC4-mediated methotrexate transport. J Pharmacol Exp Ther. 2007 Jan;320(1):229-35.
• [3] Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system. Cancer Res. 2002 Jun 1;62(11):3144-50.
• [4] ATP-binding cassette C transporters in human pancreatic carcinoma cell lines. Upregulation in 5-fluorouracil-resistant cells. Pancreatology. 2009;9(1-2):136-44.
• [5] The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9244-9.
• [6] Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007.
• [7] Steroid and bile acid conjugates are substrates of human multidrug-resistance protein (MRP) 4 (ATP-binding cassette C4). Biochem J. 2003 Apr 15;371(Pt 2):361-7.
• [8] P-glycoprotein, but not multidrug resistance protein 4, plays a role in the systemic clearance of irinotecan and SN-38 in mice. Drug Metab Lett. 2010 Dec;4(4):195-201.
• [9] Polymorphisms in multidrug resistance-associated protein gene 4 is associated with outcome in childhood acute lymphoblastic leukemia. Blood. 2009 Aug 13;114(7):1383-6.
• [10] Role of glutathione in the multidrug resistance protein 4 (MRP4/ABCC4)-mediated efflux of cAMP and resistance to purine analogues. Biochem J. 2002 Feb 1;361(Pt 3):497-503.