Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMWXBYC)

Drug Name

N-Aminoethylmorpholine Drug Info

Synonyms

4-(2-Aminoethyl)morpholine; 2038-03-1; 2-morpholinoethanamine; 4-Morpholineethanamine; 2-Morpholinoethylamine; N-Aminoethylmorpholine; 2-(Morpholin-4-Yl)Ethan-1-Amine; N-(2-Aminoethyl)morpholine; Morpholine, 4-(2-aminoethyl)-; N-2-Aminoethylmorpholine; 2-morpholin-4-ylethanamine; 2-morpholin-4-ylethylamine; 2-Morpholin-4-yl-ethylamine; N-2-Aminoethylmorfolin [Czech]; n-aminoethyl morpholine; N-2-Aminoethylmorfolin; N-(Aminoethyl)morpholine; beta-Aminoaethyl-morpholin [German]; 2-morpholino-1-ethanamine

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 408285
CAS Number: CAS 2038-03-1
TTD Drug ID: DMWXBYC

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Cathepsin D (CTSD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID10498202C1	DMXE0F2	Multiple sclerosis	8A40	Clinical trial	[2]
CI-992	DMBHYIJ	Hypertension	BA00-BA04	Terminated	[3]
Alpha-D-Mannose	DMF5DLW	Discovery agent	N.A.	Investigative	[1]
Grassystatin a	DM1PWX2	Discovery agent	N.A.	Investigative	[4]
PMID8410973C3	DM6J5KY	Discovery agent	N.A.	Investigative	[5]
KNI-10006	DMMISH6	Discovery agent	N.A.	Investigative	[6]
GRL-7234	DMR93MK	Discovery agent	N.A.	Investigative	[7]
S-Methylcysteine	DMAMRKS	Discovery agent	N.A.	Investigative	[1]
Carbocyclic Peptidomimetic	DM87SOX	Discovery agent	N.A.	Investigative	[8]
1h-Benoximidazole-2-Carboxylic Acid	DMNZAVE	Discovery agent	N.A.	Investigative	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cathepsin D (CTSD)	TTPT2QI	CATD_HUMAN	Inhibitor	[1]

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References

1	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
2	Synthesis and structure activity relationships of novel small molecule cathepsin D inhibitors. Bioorg Med Chem Lett. 1999 Sep 6;9(17):2531-6.
3	Structure-activity relationships of a series of 2-amino-4-thiazole-containing renin inhibitors. J Med Chem. 1992 Jul 10;35(14):2562-72.
4	Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation. J Med Chem. 2009 Sep 24;52(18):5732-47.
5	Specificity in the binding of inhibitors to the active site of human/primate aspartic proteinases: analysis of P2-P1-P1'-P2' variation. J Med Chem. 1993 Sep 3;36(18):2614-20.
6	alpha-Substituted norstatines as the transition-state mimic in inhibitors of multiple digestive vacuole malaria aspartic proteases. Bioorg Med Chem. 2009 Aug 15;17(16):5933-49.
7	Design, synthesis, and X-ray structure of potent memapsin 2 (beta-secretase) inhibitors with isophthalamide derivatives as the P2-P3-ligands. J Med Chem. 2007 May 17;50(10):2399-407.
8	Structure-based design, synthesis, and memapsin 2 (BACE) inhibitory activity of carbocyclic and heterocyclic peptidomimetics. J Med Chem. 2005 Aug 11;48(16):5175-90.