General Information of Drug (ID: DMXHI89)

Drug Name
Velac Gel Drug Info
Synonyms Clindamycin/tretinoin
Indication
Disease Entry ICD 11 Status REF
Acne vulgaris ED80 Phase 3 [1]
Cross-matching ID
TTD Drug ID
DMXHI89

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [3]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [5]
Adapalene DMX2358 Acne vulgaris ED80 Approved [6]
Fenretinide DMRD5SP Macular degeneration 9B78.3 Phase 3 [7]
Peretinoin DMESAZK Hepatocellular carcinoma 2C12.02 Phase 3 [8]
13-cis-retinoic acid DMTZ1A5 Glioma 2A00.0 Phase 3 [9]
Amsilarotene DMOB01U Solid tumour/cancer 2A00-2F9Z Phase 2 [10]
LAS-41001 DMXZ4BK Rosacea ED90.0 Discontinued in Preregistration [11]
IRX-4310 DMUYQH8 Psoriasis vulgaris EA90 Discontinued in Phase 3 [12]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Retinoic acid receptor (RAR) TTOD7B3 NOUNIPROTAC Inhibitor [2]

References

1 Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR alpha with a novel putative transcription factor, PML. Cell. 1991 Aug 23;66(4):663-74.
2 Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR alpha with a novel putative transcription factor, PML. Cell. 1991 Aug 23;66(4):663-74.
3 Vitamins and cofactors: highlights of ESBOC 2009. Nat Chem Biol. 2009 Aug;5(8):530-3.
4 Retinoids--which dermatological indications will benefit in the near future Skin Pharmacol Appl Skin Physiol. 2001 Sep-Oct;14(5):303-15.
5 Retinoid agonist isotretinoin ameliorates obstructive renal injury. J Urol. 2003 Oct;170(4 Pt 1):1398-402.
6 A review of adapalene in the treatment of acne vulgaris. J Adolesc Health. 2008 Nov;43(5):421-4.
7 National Cancer Institute Drug Dictionary (drug id 39582).
8 Peretinoin, an acyclic retinoid, improves the hepatic gene signature of chronic hepatitis C following curative therapy of hepatocellular carcinoma. BMC Cancer. 2013 Apr 15;13:191.
9 13-cis retinoic acid exerts its specific activity on human sebocytes through selective intracellular isomerization to all-trans retinoic acid and binding to retinoid acid receptors. J Invest Dermatol. 2000 Aug;115(2):321-7.
10 Initial clinical trial of oral TAC-101, a novel retinoic acid receptor-alpha selective retinoid, in patients with advanced cancer. J Clin Oncol. 2002 Aug 15;20(16):3522-32.
11 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027956)
12 An antagonist of retinoic acid receptors more effectively inhibits growth of human prostate cancer cells than normal prostate epithelium. Br J Cancer. 2004 Aug 2;91(3):580-8.