Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMXMZRE)

• Drug Name: 3-(4-bromophenyl)-1,1-dimethylthiourea Drug Info
• Synonyms: 3-(4-bromophenyl)-1,1-dimethylthiourea; CHEMBL249923; 75105-07-6; 3-(p-Bromophenyl)-1,1-dimethylthiourea; AC1NT9ZG; CTK2G1172; DTXSID30418775; YZPBPTSRPUXFGV-UHFFFAOYSA-N; STL265123; BDBM50223160; AKOS023092916; AKOS009470673; MCULE-1938000461; 1-(4-Bromophenyl)-3,3-dimethylthiourea; N'-(4-Bromophenyl)-N,N-dimethylthiourea #; Thiourea, N'-(4-bromophenyl)-N,N-dimethyl-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 5376123
  CAS Number: CAS 75105-07-6
  TTD Drug ID: DMXMZRE

Molecule-Related Drug Atlas

Drug(s) Targeting Bacterial Urease (Bact ureC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetohydroxamic Acid	DMYX7NI	Urinary tract infection	GC08	Approved	[2]
3-(4-bromobenzyl)-1,1-dimethylselenourea	DMAKMIJ	Discovery agent	N.A.	Investigative	[1]
1-cyclohexyl-1-isopropyl-3,3-dimethylselenourea	DMS10LE	Discovery agent	N.A.	Investigative	[1]
3-dodecyl-1,1-dimethylthiourea	DMO5EBI	Discovery agent	N.A.	Investigative	[1]
N-glycylglycinehydroxamic acid	DMPEZHC	Discovery agent	N.A.	Investigative	[3]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial Urease (Bact ureC)	TTAS2UO	URE1_KLEAE	Inhibitor	[1]

References

• [1] Facile one-pot synthesis of thio and selenourea derivatives: a new class of potent urease inhibitors. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6387-91.
• [2] Enzymatic, immunological and phylogenetic characterization of Brucella suis urease. BMC Microbiol. 2008 Jul 19;8:121.
• [3] Design, synthesis, and evaluation of novel organophosphorus inhibitors of bacterial ureases. J Med Chem. 2008 Sep 25;51(18):5736-44.