Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMXWK1A)

• Drug Name: Erysubin E Drug Info
• Synonyms: Erysubin E; CHEMBL1086764; AC1LCTGM; BDBM50311581; InChI=1/C25H26O5/c1-14(2)5-6-15-11-17-21(12-19(15)26)28-13-25(27)18-7-8-20-16(22(18)29-23(17)25)9-10-24(3,4)30-20/h5,7-12,23,26-27H,6,13H2,1-4H3/t23-,25+/m0/s; 3H,7H-pyrano[2',3':6,7]benzofuro[3,2-c][1]benzopyran-6b,10(12bH)-diol, 3,3-dimethyl-11-(3-methyl-2-butenyl)-, (6bS,12bS)-; 3,3-Dimethyl-11-(3-methyl-but-2-enyl)-3H,12bH-4,8,13-trioxa-dibenzo[a,i]fluorene-6b,10-diol

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 637080
  TTD Drug ID: DMXWK1A

Molecule-Related Drug Atlas

Drug(s) Targeting Influenza Neuraminidase (Influ NA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Oseltamivir	DMGO72P	Influenza	1E30-1E32	Approved	[3]
Zanamivir	DMFMBZ4	Influenza	1E30-1E32	Approved	[3]
Peramivir	DMNXY5K	Influenza virus infection	1E30-1E32	Approved	[4]
UX-001	DMD2O0L	Hereditary inclusion body myositis	4A41.2	Phase 3	[5]
CS-8958	DM4CSDH	Influenza virus infection	1E30-1E32	Phase 3	[4]
DAS-181	DM0Y8JP	Influenza virus infection	1E30-1E32	Phase 2	[6]
Lactose	DMO4GPK	Discovery agent	N.A.	Phase 1	[5]
GS-3435	DMV7JC6	Influenza virus infection	1E30-1E32	Terminated	[7]
BCX-140	DMBJERO	Influenza virus infection	1E30-1E32	Terminated	[8]
Alpha-D-Mannose	DMF5DLW	Discovery agent	N.A.	Investigative	[5]

Drug(s) Targeting PTPN1 messenger RNA (PTPN1 mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[9]
TRYPAN BLUE	DM4NTMO	Ophthalmic surgery injury	PK97	Approved	[10]
URSOLIC ACID	DM4SOAW	Metabolic syndrome x	5C50-5D2Z	Phase 2	[1]
ISIS 113715	DMUPD4G	Type-2 diabetes	5A11	Phase 2	[11]
ISIS-PTP1Brx	DMJGVXT	Type-2 diabetes	5A11	Phase 2	[12]
ERTIPROTAFIB	DMJXEV7	Type-2 diabetes	5A11	Terminated	[13]
Acetate Ion	DMD08RH	Discovery agent	N.A.	Investigative	[5]
B-Octylglucoside	DMMO75G	Discovery agent	N.A.	Investigative	[5]
2-Methyl-2,4-Pentanediol	DMD45CU	Discovery agent	N.A.	Investigative	[5]
Double Oxidized Cysteine	DM6TU84	Discovery agent	N.A.	Investigative	[5]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Influenza Neuraminidase (Influ NA)	TT50QJ3	NRAM_I33A0	Inhibitor	[2]
PTPN1 messenger RNA (PTPN1 mRNA)	TTELIN2	PTN1_HUMAN	Inhibitor	[1]

References

• [1] Cytotoxic and PTP1B inhibitory activities from Erythrina abyssinica. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6745-9.
• [2] Prenylated pterocarpans as bacterial neuraminidase inhibitors. Bioorg Med Chem. 2010 May 1;18(9):3335-44.
• [3] Current and future antiviral therapy of severe seasonal and avian influenza. Antiviral Res. 2008 Apr;78(1):91-102.
• [4] Developing new antiviral agents for influenza treatment: what does the future hold Clin Infect Dis. 2009 Jan 1;48 Suppl 1:S3-13.
• [5] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [6] Inhibition of neuraminidase inhibitor-resistant influenza virus by DAS181, a novel sialidase fusion protein. PLoS One. 2009 Nov 6;4(11):e7838.
• [7] US patent application no. 2010,0081,713, Compositions and methods for treating viral infections.
• [8] CN patent application no. 104447481, Benzoic acid thiourea anti-influenza virus compounds as well as preparation method and use thereof.
• [9] Periodinates: a new class of protein tyrosine phosphatase inhibitors. Bioorg Med Chem Lett. 1999 Feb 8;9(3):353-6.
• [10] Evans Blue and other dyes as protein tyrosine phosphatase inhibitors. Bioorg Med Chem Lett. 2004 Apr 19;14(8):1923-6.
• [11] Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2009).
• [12] Clinical pipeline report, company report or official report of ISIS Pharmaceuticals.
• [13] 2-O-carboxymethylpyrogallol derivatives as PTP1B inhibitors with antihyperglycemic activity. Bioorg Med Chem Lett. 2007 Oct 1;17(19):5357-60.