Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMXY5AV)

• Drug Name: AH-9700 Drug Info
• Synonyms: UNII-2NG1J5TE78; 2NG1J5TE78; AH-9700; 337359-08-7; Pyrrolidine, 1-(2-(3,4-dihydro-6,7-dimethyl-2-naphthalenyl)ethyl)-, (2E)-2-butenedioate (1:1)

Indication

Disease Entry	ICD 11	Status	REF
Pollakiuria	MF50.1	Terminated	[1]

• Cross-matching ID:
  PubChem CID: 9842381
  CAS Number: CAS 337359-08-7
  TTD Drug ID: DMXY5AV

Molecule-Related Drug Atlas

Drug(s) Targeting Opioid receptor sigma 1 (OPRS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dextromethorphan	DMUDJZM	Allergic rhinitis	CA08.0	Approved	[3]
Dextromethorphan Polistirex	DMEHCY5	Dry cough	MD12	Approved	[4]
CM-2395	DMASPWR	Schizophrenia	6A20	Phase 3	[5]
AVP-786	DMV1SOR	Alzheimer disease	8A20	Phase 3	[6]
ADX N05	DMLBYRA	Mood disorder	6A60-6E23	Phase 3	[7]
Igmesine	DMH97XA	Major depressive disorder	6A70.3	Phase 2	[8]
OPC-14523	DMB1WF3	Bulimia nervosa	6B81	Phase 2	[9]
ANAVEX 2-73	DM67OU4	Alzheimer disease	8A20	Phase 1	[10]
SSR-125047	DMSUFW6	Schizophrenia	6A20	Phase 1	[11]
SA-5845	DM6XZRL	Central nervous system disease	8A04-8D87	Phase 1	[12]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Opioid receptor sigma 1 (OPRS1)	TT5TPI6	SGMR1_HUMAN	Modulator	[2]

References

• [1] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010610)
• [2] Pharmacological actions of AH-9700 on micturition reflex in anesthetized rats. Eur J Pharmacol. 2001 Jan 26;412(2):171-9.
• [3] Dextromethorphan/quinidine: AVP 923, dextromethorphan/cytochrome P450-2D6 inhibitor, quinidine/dextromethorphan. Drugs R D. 2005;6(3):174-7.
• [4] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [5] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031127)
• [6] Antitussives and substance abuse. Subst Abuse Rehabil. 2013 Nov 6;4:75-82.
• [7] Clinical pipeline report, company report or official report of SK BioPhamaceuticals.
• [8] Antiamnesic and neuroprotective effects of donepezil against learning impairments induced in mice by exposure to carbon monoxide gas. J Pharmacol Exp Ther. 2006 Jun;317(3):1307-19.
• [9] Antidepressant-like responses to the combined sigma and 5-HT1A receptor agonist OPC-14523. Neuropharmacology. 2001 Dec;41(8):976-88.
• [10] 2011 Pipeline of Anavex.
• [11] The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22.
• [12] Tumor imaging with 2 sigma-receptor ligands, 18F-FE-SA5845 and 11C-SA4503: a feasibility study. J Nucl Med. 2004 Nov;45(11):1939-45.