Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMYAIUB)

Drug Name

Valortim Drug Info

Synonyms

Anthrax antibody, Medarex; MDX-1303; Anthrax antibody, Medarex/PharmAthene; Anti-B anthracis, Bristol Myers Squibb/PharmAthene; Anti-B anthracis PA (anthrax), Medarex/BMS/PharmAthene

Indication

Disease Entry	ICD 11	Status	REF
Bacterial infection	1A00-1C4Z	Phase 1	[1]

Cross-matching ID

TTD Drug ID: DMYAIUB

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

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Drug(s) Targeting Bacterial Protective antigen (Bact pagA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Raxibacumab	DM7QG0M	Anthrax	1B97	Approved	[3]
IQ-DAA	DMHP71R	Bacillus anthracis infection	1G40	Phase 1	[4]
AVP-21D9	DMMWEH6	Bacillus anthracis infection	1G40	Phase 1	[5]
Anthrax vaccine	DM9GSWY	Bacillus anthracis infection	1G40	Discontinued in Phase 1	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial Protective antigen (Bact pagA)	TT3YGCD	PAG_BACAN	Not Available	[2]

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References

1	ClinicalTrials.gov (NCT01265745) Dose Escalation Study of Valortim (MDX-1303) Administered Intravenously (IV) in Healthy, Normal Subjects. U.S. National Institutes of Health.
2	Phase I Study Evaluating the Safety and Pharmacokinetics of MDX-1303, a Fully Human Monoclonal Antibody against Bacillus anthracis Protective Antigen, in Healthy Volunteers. Clin Vaccine Immunol. 2011 December; 18(12): 2136-2142.
3	Modulation of innate and adaptive immune responses by tofacitinib (CP-690,550). J Immunol. 2011 Apr 1;186(7):4234-43.
4	Anti-toxin antibodies in prophylaxis and treatment of inhalation anthrax.Future Microbiol.2009 Feb;4(1):35-43.
5	Efficacy and Safety of AVP-21D9, an Anthrax Monoclonal Antibody, in Animal Models and Humans. Antimicrob Agents Chemother. 2014 July; 58(7): 3618-3625.
6	Annual Reports in Medicinal Chemistry. Annette M. Doherty. 2005. Page(214).