Details of the Drug

General Information of Drug (ID: DM9GSWY)

Drug Name
Anthrax vaccine
Synonyms Anthrax vaccine, DynPort/AVANT; Injectable anthrax vaccine, DynPort/AVANT; Anthrax vaccine (injectable), DynPort/AVANT
Indication
Disease Entry ICD 11 Status REF
Bacillus anthracis infection 1G40 Discontinued in Phase 1 [1]
Drug Type
Vaccine
Cross-matching ID
DrugBank ID
DB11003
TTD ID
D07TRV

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Bacterial Protective antigen (Bact pagA) TT3YGCD PAG_BACAN Not Available [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Anthrax vaccine (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Talazoparib DM1KS78 Moderate Antagonize the effect of Anthrax vaccine when combined with Talazoparib. Breast cancer [2C60-2C6Y] [7]
LY2835219 DM93VBZ Moderate Antagonize the effect of Anthrax vaccine when combined with LY2835219. Breast cancer [2C60-2C6Y] [7]
Polatuzumab vedotin DMF6Y0L Moderate Antagonize the effect of Anthrax vaccine when combined with Polatuzumab vedotin. Diffuse large B-cell lymphoma [2A81] [7]
Axicabtagene ciloleucel DMYHN59 Moderate Antagonize the effect of Anthrax vaccine when combined with Axicabtagene ciloleucel. Diffuse large B-cell lymphoma [2A81] [7]
Bay 80-6946 DMLOS5R Moderate Antagonize the effect of Anthrax vaccine when combined with Bay 80-6946. Follicular lymphoma [2A80] [7]
Avapritinib DMK2GZX Moderate Antagonize the effect of Anthrax vaccine when combined with Avapritinib. Gastrointestinal stromal tumour [2B5B] [7]
177Lu-DOTATATE DMT8GVU Moderate Antagonize the effect of Anthrax vaccine when combined with 177Lu-DOTATATE. Hepatitis virus infection [1E50-1E51] [7]
Brigatinib DM7W94S Moderate Antagonize the effect of Anthrax vaccine when combined with Brigatinib. Lung cancer [2C25] [7]
Lurbinectedin DMEFRTZ Moderate Antagonize the effect of Anthrax vaccine when combined with Lurbinectedin. Lung cancer [2C25] [7]
GDC-0199 DMH0QKA Moderate Antagonize the effect of Anthrax vaccine when combined with GDC-0199. Mature B-cell leukaemia [2A82] [7]
IPI-145 DMWA24P Moderate Antagonize the effect of Anthrax vaccine when combined with IPI-145. Mature B-cell leukaemia [2A82] [7]
Acalabrutinib DM7GCVW Moderate Antagonize the effect of Anthrax vaccine when combined with Acalabrutinib. Mature B-cell lymphoma [2A85] [7]
Tisagenlecleucel DMM9BJD Moderate Antagonize the effect of Anthrax vaccine when combined with Tisagenlecleucel. Mature B-cell lymphoma [2A85] [7]
Selinexor DMBD4K3 Moderate Antagonize the effect of Anthrax vaccine when combined with Selinexor. Multiple myeloma [2A83] [7]
Belantamab mafodotin DMBT3AI Moderate Antagonize the effect of Anthrax vaccine when combined with Belantamab mafodotin. Multiple myeloma [2A83] [7]
Deflazacort DMV0RNS Moderate Antagonize the effect of Anthrax vaccine when combined with Deflazacort. Muscular dystrophy [8C70] [7]
Inebilizumab DMI0RHA Moderate Antagonize the effect of Anthrax vaccine when combined with Inebilizumab. Nervous system paraneoplastic/autoimmune disorder [8E4A] [7]
Atezolizumab DMMF8U0 Moderate Antagonize the effect of Anthrax vaccine when combined with Atezolizumab. Non-small cell lung cancer [2C25] [7]
Rucaparib DM9PVX8 Moderate Antagonize the effect of Anthrax vaccine when combined with Rucaparib. Ovarian cancer [2C73] [7]
MK-4827 DMLYGH4 Moderate Antagonize the effect of Anthrax vaccine when combined with MK-4827. Ovarian cancer [2C73] [7]
Brodalumab DMASDQ6 Moderate Antagonize the effect of Anthrax vaccine when combined with Brodalumab. Psoriasis [EA90] [7]
Tildrakizumab DMLW9HG Moderate Antagonize the effect of Anthrax vaccine when combined with Tildrakizumab. Psoriasis [EA90] [7]
Risankizumab DMM32GT Moderate Antagonize the effect of Anthrax vaccine when combined with Risankizumab. Psoriasis [EA90] [7]
Ixekizumab DMXW92T Moderate Antagonize the effect of Anthrax vaccine when combined with Ixekizumab. Psoriasis [EA90] [7]
Upadacitinib DM32B5U Moderate Antagonize the effect of Anthrax vaccine when combined with Upadacitinib. Rheumatoid arthritis [FA20] [7]
Baricitinib DM4ONW5 Moderate Antagonize the effect of Anthrax vaccine when combined with Baricitinib. Rheumatoid arthritis [FA20] [7]
Sarilumab DMOGNXY Moderate Antagonize the effect of Anthrax vaccine when combined with Sarilumab. Rheumatoid arthritis [FA20] [7]
Mogamulizumab DMISH0Z Moderate Antagonize the effect of Anthrax vaccine when combined with Mogamulizumab. Sezary syndrome [2B02] [7]
LEE011 DMMX75K Moderate Antagonize the effect of Anthrax vaccine when combined with LEE011. Solid tumour/cancer [2A00-2F9Z] [7]
Durvalumab DM4PVDY Moderate Antagonize the effect of Anthrax vaccine when combined with Durvalumab. Ureteral cancer [2C92] [7]
⏷ Show the Full List of 30 DDI Information of This Drug

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017549)
2 Annual Reports in Medicinal Chemistry. Annette M. Doherty. 2005. Page(214).
3 Modulation of innate and adaptive immune responses by tofacitinib (CP-690,550). J Immunol. 2011 Apr 1;186(7):4234-43.
4 Anti-toxin antibodies in prophylaxis and treatment of inhalation anthrax.Future Microbiol.2009 Feb;4(1):35-43.
5 Phase I Study Evaluating the Safety and Pharmacokinetics of MDX-1303, a Fully Human Monoclonal Antibody against Bacillus anthracis Protective Antigen, in Healthy Volunteers. Clin Vaccine Immunol. 2011 December; 18(12): 2136-2142.
6 Efficacy and Safety of AVP-21D9, an Anthrax Monoclonal Antibody, in Animal Models and Humans. Antimicrob Agents Chemother. 2014 July; 58(7): 3618-3625.
7 CDC. Centers for Disease Control and Prevention/ "Recommendations of the advisory committtee on immunization practices (ACIP): use of vaccines and immune globulins in persons with altered immunocompetence." MMWR Morb Mortal Wkly Rep 42(RR-04) (1993): 1-18. [PMID: 20300058]