Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMYBWL9)

Drug Name

Imlunestrant Drug Info

Synonyms

Imlunestrant; UNII-9CXQ3PF69U; Imlunestrant [USAN]; LY3484356; 9CXQ3PF69U; 2408840-26-4; LY-3484356; WHO 12039; (5R)-5-(4-(2-(3-(fluoromethyl)azetidin-1-yl)ethoxy)phenyl)-8-(trifluoromethyl)-5H-(1)benzopyrano(4,3-c)quinolin-2-ol; 5H-(1)Benzopyrano(4,3-c)quinolin-2-ol, 5-(4-(2-(3-(fluoromethyl)-1-azetidinyl)ethoxy)phenyl)-8-(trifluoromethyl)-, (5R)-; IMLUNESTRANT [INN]; CHEMBL5095183; SCHEMBL22002569; GTPL12896; UVBQMXOKKDCBJN-MUUNZHRXSA-N; BDBM443429; GLXC-26209; US10654866, Example 1A; EX-A6123; Ly 3484356; Example 1B {WO2020014435A1]; HY-145572; CS-0376104; (5R)-5-[4-[2-[3-(fluoromethyl)azetidin-1-yl]ethoxy]phenyl]-8-(trifluoromethyl)-5H-chromeno[4,3-c]quinolin-2-ol

Indication

Disease Entry	ICD 11	Status	REF
Breast cancer	2C60-2C65	Phase 3	[1]

Cross-matching ID

PubChem CID: 146603228
TTD Drug ID: DMYBWL9

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Estrogen receptor (ESR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[2]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[3]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[3]
Estradiol Valerate	DM8MC6O	Hormone replacement therapy	8E01	Approved	[4]
Estradiol Acetate	DM07U2A	Hormone replacement therapy	8E01	Approved	[4]
Estradiol Cypionate	DM27Z5T	Hormone replacement therapy	8E01	Approved	[4]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[5]
Raloxifene	DMDKF3M	Osteoporosis	FB83.0	Approved	[6]
Ospemifene	DMC4GEI	Dyspareunia	GA12	Approved	[7]
Toremifene	DMQYUWG	Breast cancer	2C60-2C65	Approved	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Estrogen receptor (ESR)	TTZAYWL	ESR1_HUMAN	Degrader	[1]

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References

1	ClinicalTrials.gov (NCT04975308) EMBER-3: A Phase 3, Randomized, Open-Label Study of Imlunestrant, Investigator's Choice of Endocrine Therapy, and Imlunestrant Plus Abemaciclib in Patients With Estrogen Receptor Positive, HER2 Negative Locally Advanced or Metastatic Breast Cancer Previously Treated With Endocrine Therapy. U.S.National Institutes of Health.
2	Modulators of vascular sex hormone receptors and their effects in estrogen-deficiency states associated with menopause. Recent Pat Cardiovasc Drug Discov. 2008 Nov;3(3):165-86.
3	Reprint of Are all estrogens the same Maturitas. 2008 Sep-Oct;61(1-2):195-201.
4	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
5	17alpha-Ethinylestradiol hinders nucleotide excision repair in zebrafish liver cells. Aquat Toxicol. 2009 Dec 13;95(4):273-8.
6	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 620).
7	Clinical pipeline report, company report or official report of Shionogi (2011).
8	Effect of selective estrogen receptor modulators on cell proliferation and estrogen receptor activities in normal human prostate stromal and epithe... Prostate Cancer Prostatic Dis. 2009;12(4):375-81.