Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMYG0M5)

Drug Name
IOX1 Drug Info
Synonyms
5852-78-8; 8-Hydroxyquinoline-5-Carboxylic Acid; 8-Hydroxy-5-quinolinecarboxylic acid; 5-Carboxy-8-hydroxyquinoline; IOX 1; UNII-JM015YQC1C; IOX-1; 5-carboxy-8HQ; 5-Quinolinecarboxylic acid, 8-hydroxy-; JM015YQC1C; CHEMBL1230640; 4bio; 4jht; 8XQ; 4ie4; AC1LA0UV; MLS002729056; GTPL8230; SCHEMBL6068195; KS-00000PPH; CHEBI:93239; CTK1E0142; DTXSID20207236; AOB6499; JGRPKOGHYBAVMW-UHFFFAOYSA-N; MolPort-006-673-354; HMS3653E21; ZINC5933707; BCP16996; s7234; BDBM50396018; 2184AH; IOX1, > AKOS016371793
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
459617
ChEBI ID
CHEBI:93239
CAS Number
CAS 5852-78-8
TTD Drug ID
DMYG0M5

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Patented Agent(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting HIF-prolyl hydroxylase 2 (HPH-2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
FG-4592 DM4XSQ2 Anaemia 3A90 Phase 3 [2]
US9422240, 1-298 DMH7DL5 N. A. N. A. Patented [3]
US8598210, Table XV, 2 DMDK98P N. A. N. A. Patented [4]
US8536181, A41 DMF9LNO N. A. N. A. Patented [5]
US8598210, Table XV, 5 DMEU5ST N. A. N. A. Patented [6]
US8536181, C17 DMRTL63 N. A. N. A. Patented [7]
US8598210, Table XV, 4 DM3XWMO N. A. N. A. Patented [8]
US8921389, 210 DME1A80 N. A. N. A. Patented [9]
US8536181, C35 DMAM51Z N. A. N. A. Patented [5]
US10100051, Compound 2 DMWESZ1 N. A. N. A. Patented [10]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Lysine-specific demethylase 6B (KDM6B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
GSK-J1 DMY3SEN Discovery agent N.A. Investigative [11]
Drug(s) Targeting Lysine-specific demethylase 4C (KDM4C)
Drug Name Drug ID Indication ICD 11 Highest Status REF
PMID25468267-Compound-46 DMSKCEH N. A. N. A. Patented [12]
Hydroxamate analog 1 DMGATHZ N. A. N. A. Patented [12]
Pyrido[1,2-a]indole-1.-carboxylic acid analog 4 DM09FOQ N. A. N. A. Patented [12]
Pyrido[1,2-a]indole-1.-carboxylic acid analog 1 DMF0XI3 N. A. N. A. Patented [12]
PMID25468267-Compound-56 DMAI19Z N. A. N. A. Patented [12]
Pyrido[1,2-a]indole-1.-carboxylic acid analog 5 DMO3QDW N. A. N. A. Patented [12]
PMID25468267-Compound-47 DMG2JEK N. A. N. A. Patented [12]
Pyrido[1,2-a]indole-1.-carboxylic acid analog 7 DMXY3F0 N. A. N. A. Patented [12]
Pyrido[1,2-a]indole-1.-carboxylic acid analog 3 DMCLKBY N. A. N. A. Patented [12]
Flavonoid derivative 6 DM0E38G N. A. N. A. Patented [12]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
HIF-prolyl hydroxylase 2 (HPH-2) TT9ISBX EGLN1_HUMAN Inhibitor [1]
Lysine-specific demethylase 3A (KDM3A) TTKXS4A KDM3A_HUMAN Inhibitor [1]
Lysine-specific demethylase 4C (KDM4C) TTV8CRH KDM4C_HUMAN Inhibitor [1]
Lysine-specific demethylase 6B (KDM6B) TTDIJUQ KDM6B_HUMAN Inhibitor [1]

References

1 A cell-permeable ester derivative of the JmjC histone demethylase inhibitor IOX1. ChemMedChem. 2014 Mar;9(3):566-71.
2 Crystalline forms of a prolyl hydroxylase inhibitor. US9115085.
3 Partially saturated nitrogen-containing heterocyclic compound. US9422240.
4 Prolyl hydroxylase inhibitors and methods of use. US9598370.
5 Prolyl hydroxylase inhibitors. US8536181.
6 Prolyl hydroxylase inhibitors and method of use. US8722895.
7 Methods for increasing the stabilization of hypoxia inducible factor-1 alpha. US8778412.
8 Prolyl hydroxylase inhibitors and methods of use. US8598210.
9 Naphthyridine derivatives as inhibitors of Hypoxia inducible factor (HIF) hydroxylase. US9695170.
10 Compound of 5-hydroxyl-1,7-naphthyridine substituted by aryloxy or heteroaryloxy, preparation method thereof and pharmaceutical use thereof. US10100051.
11 A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature. 2012 Aug 16;488(7411):404-8.
12 KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44.