Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMYL6RA)

Drug Name
SPH3127 Drug Info
Synonyms
SPH3127; SPH-3127; 1399849-02-5; C2M78A9V6Z; CHEMBL4110551; SCHEMBL16471589; GTPL12196; BDBM212579; GLXC-26423; compound 18 [PMID: 35939295]; HY-151111; CS-0567609; US9278944, 270; Carbamic acid, N-(3-(3-((1R)-1-(cyclopropyl((2R)-2-morpholinylcarbonyl)amino)ethyl)-6-methyl-1H-pyrazolo(3,4-b)pyridin-1-yl)propyl)-, methyl ester; Methyl (3-(3-((R)-1-((R)-N-cyclopropylmorpholine-2-carboxamido)ethyl)-6-methyl-1H-pyrazolo[3,4-b]pyridin-1-yl)propyl)carbamate
Indication
Disease Entry ICD 11 Status REF
Ulcerative colitis DD71 Phase 2 [1]
Cross-matching ID
PubChem CID
117877477
TTD Drug ID
DMYL6RA

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Angiotensinogenase renin (REN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aliskiren DM1BV7W Hypertension BA00-BA04 Approved [3]
Remikiren DMNAKLY Hypertension BA00-BA04 Approved [4]
SPP-600 DMOVQP8 Hypertension BA00-BA04 Phase 2 [5]
TAK-272 DM81UAZ Type-2 diabetes 5A11 Phase 2 [6]
SR-43845 DMTOCIV Glaucoma/ocular hypertension 9C61 Phase 2 [7]
CP-80794 DMT3ORQ Hypertension BA00-BA04 Phase 2 [8]
VTP-27999 DMQEOD6 Hypertension BA00-BA04 Phase 1 [9]
ACT-178882 DMOZ3AT Cardiovascular disease BA00-BE2Z Phase 1 [10]
CARD-024 DM4SNK8 Cardiovascular disease BA00-BE2Z Phase 1 [11]
FK-906 DMTEW80 Hypertension BA00-BA04 Discontinued in Phase 2 [12]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Angiotensinogenase renin (REN) TTB2MXP RENI_HUMAN Inhibitor [2]

References

1 ClinicalTrials.gov (NCT05770609) A Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel, Dose-finding Phase II Clinical Study to Evaluate the Efficacy and Safety of SPH3127 Tablets in the Treatment of Mild to Moderate Ulcerative Colitis. U.S.National Institutes of Health.
2 Discovery of SPH3127: A Novel, Highly Potent, and Orally Active Direct Renin Inhibitor. J Med Chem. 2022 Aug 25;65(16):10882-10897.
3 Comparative effects of aliskiren-based and ramipril-based therapy on the renin system during long-term (6 months) treatment and withdrawal in patie... J Renin Angiotensin Aldosterone Syst. 2009 Sep;10(3):157-67.
4 Functional expression of the renin-angiotensin system in human podocytes. Am J Physiol Renal Physiol. 2006 Mar;290(3):F710-9.
5 Effect of SPP 635, a renin inhibitor, on intraocular pressure in glaucomatous monkey eyes. Exp Eye Res. 2012 Jan;94(1):146-9.
6 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800033655)
7 Effects of a renin inhibitor, SR 43845, and of captopril on blood pressure and plasma active renin in conscious sodium-replete macaca. J Hypertens Suppl. 1989 Apr;7(2):S33-5.
8 Synergistic effect on reduction in blood pressure with coadministration of the renin inhibitor, CP-80,794, and the angiotensin converting enzyme inhibitor, captopril. J Cardiovasc Pharmacol. 1992 Jul;20(1):75-82.
9 New Developments in the Pharmacological Treatment of Hypertension: Dead-End or a Glimmer at the Horizon . Curr Hypertens Rep. 2015; 17(6): 42.
10 Drug-drug interaction study of ACT-178882, a new renin inhibitor, and diltiazem in healthy subjects. Clin Drug Investig. 2013 Mar;33(3):207-13.
11 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2413).
12 Antihypertensive efficacy of FK906, a novel human renin inhibitor. Clin Ther. 1993 May-Jun;15(3):539-48.